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  • 1
    Electronic Resource
    Electronic Resource
    Intermittent ketoconazole therapy of chronic mucocutaneous candidiasis in childhood (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 176-180 
    Details
    ISSN: 1432-1076
    Keywords: Chronic mucocutaneous candidiasis ; Ketoconazole ; Intermittent therapy ; Mannan ; Lymphocyte transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the clinical and laboratory findings in two children with chronic mucocutaneous condidiasis (CMC) treated successfully with intermittent long-term ketoconazole therapy. Both had chronic infection of the nails, skin and mucous membranes with positive cultures for candida. Both were resistant to multiple local and systemic antifungal agents. After institution of ketoconazole therapy there was a dramatic improvement with clearing of the oral (one week), skin (two months) and nail lesions (5 months). After 8 months the drug was stopped and clinical remission persisted for 10 and 7 months respectively. Relapse of oral candidiasis was treated with a short course of ketoconazole (4–16 weeks) leading to complete healing of the lesions. Clinical improvement was not related to an amelioration in lymphocyte transformation. There was no change in the progressive deterioration of the lymphocyte responses to candida antigen which was probably due to persisting candida cell wall components (e.g. mannan).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01377351
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  • 2
    Electronic Resource
    Electronic Resource
    Freie mitteilungen (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. S240 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02201969
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  • 3
    Electronic Resource
    Electronic Resource
    Videodemonstration (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. S276 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02201975
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Recommendations of the german association of urogynecology on functional sonography of the lower female urinary tract (1996)
    Springer
    International urogynecology journal 7 (1996), S. 105-108 
    Details
    ISSN: 1433-3023
    Keywords: Female urinary incontinence ; Lower urinary tract ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Ultrasound is a complementary evaluation for the study of female urinary incontinence which allows functionalmorphological documentation. A reliable urogynecologic examination is based on the patient's history, clinical evaluation, urodynamics and imaging. Training in sonography of the female lower urinary tract should be performed within the scope of urogynecological evaluations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01902383
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  • 5
    Electronic Resource
    Electronic Resource
    Letter to the Editor (1996)
    Springer
    International urogynecology journal 7 (1996), S. 234-235 
    Details
    ISSN: 1433-3023
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907079
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  • 6
    Electronic Resource
    Electronic Resource
    Letter to the editor (1996)
    Springer
    International urogynecology journal 7 (1996), S. 270-273 
    Details
    ISSN: 1433-3023
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01901251
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  • 7
    Electronic Resource
    Electronic Resource
    Assessment of effect of photosensitizers on cytotoxicity of photodynamic therapy in human breast cancer cell cultures (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. 167-176 
    Details
    ISSN: 1432-0711
    Keywords: Photodynamic therapy ; Photosensitizers ; m-THPC ; Breast cancer ; In vitro ; Adenosine triphosphate cell viability assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Photodynamic therapy (PDT) might be of clinical value for patients with breast cancer with local recurrences or metastasis. However, there is a need for improved photosensitizers that are effective in combination with laser light and have few, if any, side-effects. We evaluated in vitro the effectiveness of a second generation photosensitizer by testing the influence of laser light on cell cultures of a human breast carcinoma cell line, incubated with meta-tetrahydroxy-phenylchlorin (m-THPC) (=Temoporfin®).Experimental design: Five thousand MCF-7 cells were plated in 96-well plates. Forty-eight hours before laser treatment, the cells were plated to achieve a monolayer configuration. Twenty-four hours after plating, they were incubated with m-THPC. On day 6 after treatment with m-THPC we lysed the cells to extract the intracellular ATP that correlates with the number of living cells. The ATP-CVA was used to assess the cytotoxicity of the tested photosensitizer m-THPC at various concentrations and the relevant laser light alone prior to their combination after six days of culture.Results: We found a dose-response for m-THPC alone ranging from 2 to 16 μg/ml. The calculated inhibition concentration to produce 50% cell kill (IC50) was 4.55 μg/ml. We also observed a very low cytotoxicity for laser irradiation alone but a very strong cell kill for the combination of m-THPC together with laser light.Conclusions: PDT gave almost total cell kill at m-THPC concentrations that are not toxic in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634488
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  • 8
    Electronic Resource
    Electronic Resource
    Assessment of effect of photosensitizers on cytotoxicity of photodynamic therapy in human breast cancer cell cultures (1995)
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. 167-176 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Photodynamic therapy ; Photosensitizers ; m-THPC ; Breast cancer ; In vitro ; Adenosine triphosphate cell viability assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract.  Background: Photodynamic therapy (PDT) might be of clinical value for patients with breast cancer with local recurrences or metastasis. However, there is a need for improved photosensitizers that are effective in combination with laser light and have few, if any, side-effects. We evaluated in vitro the effectiveness of a second generation photosensitizer by testing the influence of laser light on cell cultures of a human breast carcinoma cell line, incubated with meta-tetrahydroxyphenylchlorin (m-THPC) (=Temoporfin®). Experimental design: Five thousand MCF-7 cells were plated in 96-well plates. Forty-eight hours before laser treatment, the cells were plated to achieve a monolayer configuration. Twenty-four hours after plating, they were incubated with m-THPC. On day 6 after treatment with m-THPC we lysed the cells to extract the intracellular ATP that correlates with the number of living cells. The ATP-CVA was used to assess the cytotoxicity of the tested photosensitizer m-THPC at various concentrations and the relevant laser light alone prior to their combination after six days of culture. Results: We found a dose-response for m-THPC alone ranging from 2 to 16 µg/ml. The calculated inhibition concentration to produce 50% cell kill (IC50) was 4.55 µg/ml. We also observed a very low cytotoxicity for laser irradiation alone but a very strong cell kill for the combination of m-THPC together with laser light. Conclusions: PDT gave almost total cell kill at m-THPC concentrations that are not toxic in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634488
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Beziehungen zwischen Miktionsbeschwerden und morphologischen Veränderungen nach Inkontinenzoperationen (1989)
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 748-751 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 324 Patientinnen wird anhand postoperativer lateraler Urethrozystogramme nach der Ursache von postoperativen Miktionsbeschwerden gesucht. Die Ergebnisse zeigen, daß weder bei den fünf vaginalen noch bei den drei abdominalen Inkontinenzoperationen Überkorrekturen für die Miktionsbeschwerden verantwortlich sind. Die Ursache der Miktionsbeschwerden läßt sich mit dem lateralen Urethrozystogramm nicht erklären und muß mit anderen Methoden untersucht werden.
    Notes: Summary In a study on 324 patients, based on the postoperative lateral urethrocystogramm, we tried to find the cause for postoperative micturition complications. The results prove, that over-corrections are not responsible for micturition complications, not in the three abdominal nor in the five vaginal types of incontinence operations. The cause of micturition complications cannot be explained with the lateral urethrocystogramm. Other examination methods will have to be applied in determining the cause.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02417541
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  • 10
    Electronic Resource
    Electronic Resource
    Beziehungen zwischen Miktionsbeschwerden und tonometrischen Veränderungen im Urethraprofil nach Inkontinenzoperationen (1989)
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 751-753 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Inkontinenzoperationen führen häufig zu postoperativen Miktionsbeschwerden. An 324 Patientinnen wird untersucht, ob postoperative Urethradruckprofile Hinweise für die Ursache solcher Beschwerden geben. Bei Patientinnen mit Miktionsbeschwerden läßt sich postoperativ in umschriebenen Urethraabschnitten eine signifikant bessere urethrovesikale Drucktransmission nachweisen. Diese sind auf operationsspezifische Narbenbildungen zurückzuführen.
    Notes: Summary Incontinence operations often lead to micturition complications postoperatively. A study aimed at finding the cause for micturition complications was carried out by examining the postoperative urethra pressure profile on 324 patients. The results prove, that in patients with micturition complications postoperatively, defined urethra sections show a significant better vesico urethral pressure transmission due to scar formation depending on the operating technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02417542
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    Paper (German National Licenses)
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