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  • 1
    Electronic Resource
    Electronic Resource
    Maternal stress alters monoamine metabolites in fetal and neonatal rat brain (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 457-459 
    Details
    ISSN: 1420-9071
    Keywords: Maternal stress ; monoamine metabolites ; perinatal rat brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Heat-restraint stress given rats during the last week of gestation significantly altered dopaminergic dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA) and noradrenergic 3-methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG) forebrain-hypothalamic monoamine (MA) metabolites in female offspring. On gestational day 21, HVA and MOPEG were significantly higher and lower, and on postnatal day 1 all were higher. There were virtually no differences in brain MA concentrations in males. Thus MA metabolic concentrations differ in fetal-neonatal forebrain-hypothalamus as a function of sex differences and maternal stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940547
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitation of adrenaline in rat brain nuclei and areas by mass fragmentography (1974)
    [s.l.] : Nature Publishing Group
    Nature 251 (1974), S. 530-531 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In our preliminary experiments, 15 brain nuclei were dissected and assayed for their catecholamine content. Male rats (125?175 g) were killed by cervical fracture and the brain rapidly removed and frozen in powdered dry ice. The frozen brains were serially sectioned (400 µm, knife angle 30 to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/251530a0
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  • 3
    Electronic Resource
    Electronic Resource
    Pre- and Postnatal Ontogeny and Characterization of Dopaminergic D2, Serotonergic S2, and Spirodecanone Binding Sites in Rat Forebrain (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 40 (1983), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The ontogeny of binding sites for [3H] spiperone was studied in time-pregnant rats. Binding of [3H]spiperone to fresh homogenates of pre- and postnatal rat forebrain was characterized by Scatchard analysis and competition experiments with a number of dopaminergic and serotonergic agonists and antagonists and additional substances. A convenient discrimination of three high-affinity sites, i.e., the dopaminergic D2, serotonergic S2, and spirodecanone (Sd) sites, was obtained with l-(–)sulpiride and cis-flupenthixol. The analgesic R5573 was found not to be specific for the Sd site but to interact with all three sites. The three binding sites became detectable in sequential order. S2 and D2 binding sites were first found at embryonic days 15.75 and 17.75, respectively. The Sd site did not appear before postnatal day 8. All three binding sites reached adult values at approximately postnatal day 30. During the prenatal period, the increase in the number of D2 binding sites paralleled the rise in forebrain dopamine concentrations. The kinetics of D2 and S2 sites were the same at embryonic day 19.75 and postnatal day 30. These observations provide evidence for the presence of the receptor substrate for actions of neuroleptics on dopaminergic and serotonergic systems during fetal life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1983.tb13561.x
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  • 4
    Electronic Resource
    Electronic Resource
    Transluminale koronare Angioplastie (1998)
    Springer
    Zeitschrift für Kardiologie 87 (1998), S. s1 
    Details
    ISSN: 1435-1285
    Keywords: Schlüsselwörter Ballonangioplastie – 20 Jahre Follow-up ; Key words Percutaneous transluminal coronary angioplasty (PTCA) – 20 years follow-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: 20 Jahre nach den ersten Eingriffen mit einem nichtdehnbaren Ballonkatheter bei verengten Herzkranzgefäßen wurde zusammen mit dem Universitätsspital Zürich, der Universitätsklinik Erlangen und der Universitätsklinik Frankfurt ein komplettes Follow-up der weltweit ersten 6 Patienten erstellt. Drei von 6 Patienten zeigten sich körperlich gut belastbar; im Belastungs-EKG konnte keine Ischämiereaktion nachgewiesen werden. Ein Patient klagte seit dem Frühjahr 1997 erneut über typische Angina pectoris und wurde nichtinvasiv (Belastungs-EKG und Elektronenstrahltomographie) und invasiv kontrolliert. Zwei Patienten waren zwischenzeitlich verstorben. Die aktuellen Befunde werden im Folgenden dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050528
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of prenatal diazepam exposure on TNF-α production by rat splenocytes (1993)
    Springer
    Inflammation research 38 (1993), S. 265-272 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prenatal exposure to diazepam and other benzodiazepines (BDZ) has been found to result in a marked reduction of T-lymphocyte proliferation during postnatal development of rats. In search for pathogenic changes underlying this effect, we investigated the mitogen lipopolysaccharide (LPS) and concanavalin A (ConA) stimulated release of tumour necrosis factor (TNF)-α by mixed splenocytes of male offspring from Long Evans rats treated with 1.25 mg/kg per day diazepam from gestational day 14 to 20. In response to LPS, TNF-α release was found to be significantly lower in mixed splenocytes of two- and four-week-old treated than in control offspring. However, at eight weeks of age, prenatally diazepam-treated animals showed a significantly higher LPS-induced TNF-α release than control rats. Since monocytes/macrophages represent a major source of TNF-α, additional experiments were performed on purified spleen macrophages and lymphocytes stimulated with LPS. TNF-α release was only detectable in supernatants of adherent spleen macrophages and not in supernatants of lymphocytes. Thus, our data indicate that a disturbance in TNF-α release from macrophages is involved in the deficient immune response of prenatally diazepam-exposed rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01976219
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  • 6
    Electronic Resource
    Electronic Resource
    Alterations in interleukin-6 production by LPS- and Con A-stimulated mixed splenocytes, spleen macrophages and lymphocytes in prenatally diazepam-exposed rats (1993)
    Springer
    Inflammation research 39 (1993), S. 166-173 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prenatal exposure to diazepam leads to a suppression of mitogen or allogen-induced lymphocyte proliferation as well as to a reduced production of tumour necrosis factor (TNF)-α from rat splenocytes during postnatal development of rats. We analysed the secretion of interleukin (IL)-6 which occurs at a later stage of the cytokine cascade. Splenocytes of male offspring from Long Evans rats, treated with a daily dose of diazepam (1.25 mg/kg) from gestational day 14 to 20, were stimulated with lipopolysaccaride (LPS) and concanavalin A (Con A). In response to LPS, IL-6 liberation was significantly lower in mixed splenocytes and spleen macrophages of 2 and 8 week old prenatally diazepam-treated rats than in controls. Spleen lymphocyte preparations of prenatally treated animals exhibited a reduction of IL-6 release at 12 h and an increase at 24 h of incubation. At 2 weeks of age, Con A-induced IL-6 production could only be detected in mixed splenocytes; prenatally treated rats were releasing significantly less IL-6 than controls. In 8 week old rats, IL-6 liberation from mixed splenocytes and spleen macrophages was significantly lower in prenatally treated animals than in controls. Spleen lymphocytes presented a complex response picture depending upon incubation conditions. Our data indicate that in prenatally diazepam-exposed rats, the disturbance of cytokine release also extends to cytokines which play an important role in the later phases of immune responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01998970
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  • 7
    Electronic Resource
    Electronic Resource
    Pre- and postnatal lead exposure affects the serotonergic system in the immature rat brain (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 463-466 
    Details
    ISSN: 1420-9071
    Keywords: Lead exposure (perinatal) ; serotonin ; HPLC-EC ; rat brain ; development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of pre- and postnatal lead exposure on the development of the serotonergic system in striatum and brain stem was investigated. Serotonin and its metabolite 5-HIAA where determined by HPLC-EC. A significant decrease of 5-HT was detected in the brain stem at postnatal day 28. At both days 6 and 28 postnatal, 5-HIAA was reduced in striatum and brain stem. The results provide support to the hypothesis that developing 5-HT neurons are sensitive to relatively low levels of lead exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959945
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  • 8
    Electronic Resource
    Electronic Resource
    Über Noradrenalin und der ATP-Erschlaffungsfaktor der Irismuskulatur des Hundeauges (1971)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 182 (1971), S. 89-94 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. In dem Kammerwasser (KW) der vorderen Augenkammer (VK) des normalen Hundeauges ist Noradrenalin (NA) nicht oder nur in so geringen Mengen vorhanden, daß mit einer Methode, die noch eine Menge von 10−8 g anzeigen würde, NA nicht nachgewiesen werden kann. 2. Das gleiche negative Resultat ergibt sich auch für die durch Stimulation mit MgATP erzeugte Mydriasis. 3. Gleichzeitige und gleich intensive Stimulation des Sympathicus und Parasympathicus bewirkt einen antagonistischen Effekt auf die Receptoren der Irismuskulatur. 4. Der Mechanismus des Entstehens einer Mydriasis nach MgATP-Injektion ist verständlich bei Annahme eines „Erschlaffungsfaktors“ (EF).
    Notes: Summary 1. In the aqueous of the anterior chamber (VK) of the normal dog's eye noradrenaline (NA) is not present; or it occurs in such small quantity below 10−8 g (limit of used method to indicate NA). 2. The same is valid inspite of maximal mydriasis produced by ATP-stimulation (ATP-solution I injected into the orbita). 3. Simultaneous stimulation of the autonomic nerves of the eye produces an antagonistic effect on the receptors of the iris muscles. 4. The mechanism of the development of mydriasis after ATP-stimulation is understandable due to the relaxation-factor (Erschlaffungsfactor EF) on the sphincter-muscle after stimulation of the autonomic nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406521
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  • 9
    Electronic Resource
    Electronic Resource
    Antigenic specificity of the antibody response in humans during legionellosis (1986)
    Springer
    Infection 14 (1986), S. 108-114 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Antigen-Spezifität der menschlichen Immunantwort während der Legionella-Erkrankung wurde untersucht. Mittels Western-blot-Technik unter Verwendung von Antigenen verschiedener Legionella-Stämme wurden 22 Seren von 12 Patienten untersucht. Bei fünf von sechs Patienten war eine qualitativ gleichbleibende Reaktivität der zu verschiedenen Zeitpunkten während der Legionellose entnommenen Seren zu beobachten. Bei einem Patienten erschien zwischen dem 14. und 22. Tag nach der Infektion ein neuer IgG-Antikörper gegen ein bakterielles Antigen von 50 Kdal. Bei jedem Patienten war die IgG- und IgM-Antwort verschieden. Wenn das Patientenserum mit einer Antigen-Präparation aus dem von diesem Patienten isolierten Stamm oder aus einem nahe verwandten Isolat getestet wurde, zeigte sich eine gegen breite Anti-genbande gerichtete Antikörperantwort.
    Notes: Summary The antigenic specificity of the human immune response during legionellosis was studied. Twenty-two sera obtained from 12 individuals were studied using the Western-blot technique with antigens from various legionella. In five of six patients, the reactivity of their sera obtained at different times during legionellosis was qualitatively constant. In one patient, a new IgG antibody to a 50 Kdal bacterial antigen appeared between the 14th and 22nd day after infection. In every patient, the IgG and IgM responses differed. When the patient's serum was reacted with antigen prepared from the isolate obtained from that patient or from a closely related isolate, the antibody response appeared to be directed against broad antigenic bands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01643473
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