ISSN:
1619-7089
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A number of d-glucose analogues labelled with either the positron emitter 75Br (T 1/2=1.6 h) or the single photon emitter 123I (T 1/2=13.3 h) were studied as potential tracers for glucose utilisation in heart and brain. Of these, 3-deoxy-3-bromo-d-glucose, 3-deoxy-3-iodo-d-glucose, methyl 2-deoxy-2-bromo-β-d-glucoside and methyl 2-deoxy-2-iodo-β-d-glucoside showed little uptake of radio-activity into brain and an unfavourable ratio of heart-to-blood and heart-to-lung concentrations. In contrast, methyl 3,4,6-tri-O-acetyl-2-deoxy-2-iodo-β-d-glucoside (MTIG) and methyl 3,4,6-tri-O-acetyl-2-deoxy-2-bromo-β-d-glucoside (MTBG) showed promising brain uptake (160% MBC for MTBG) with a good brain-to-blood concentration ratio of 0.8. MTBG is not metabolically altered in the brain. Thus, this compound may be a promising tracer for measuring glucose transport if it proves to be a substrate for the hexose carrier at the blood-brain-barrier.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00522512
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