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  • 1
    Electronic Resource
    Electronic Resource
    Laminar differences in development of afferent innervation to striate cortex neurones in kittens (1982)
    Springer
    Experimental brain research 45 (1982), S. 433-446 
    Details
    ISSN: 1432-1106
    Keywords: Visual cortex ; Development ; Cortical lamination ; Kitten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied 587 cells in the striate cortex of 47 kittens, ranging in age postnatally from the 8th day to the 20th week, to explore differences in rates of functional maturation of cells and afferents among cortical layers. For all cells studied we determined spontaneous activity level, visual responsiveness, responsiveness to electrical stimulation of the afferent pathways and histologically reconstructed their laminar localization. At the 2nd–3rd week postnatally, single shocks applied to the dorsal lateral geniculate nucleus (LGN) elicited relatively inconsistent responses with long latencies in most of the cells in all layers, except in layer V where responses were consistent. In layers IVab, V, and VIu (the upper half of layer VI) the LGN-latency decreased very rapidly in the 4th week, while in layer IVc such a decrease occurred in the 5th week. In layers II+III and VIℓ (the lower half of layer VI) a less substantial decrease in latency occurred during the 4th and 5th week. At 2 weeks, nearly half of layer V cells had orientation-specific visual responses or spontaneous activity, but such cells were rare in other layers. The proportions of the specific or spontaneously active cells matured successively in the order of layers V → IVab and VIu →IVc →II+III and VIℓ. We conclude that the maturation of functional properties of cortical cells may occur successively in the above-mentioned laminar order, and that cell size and connectivity with afferents may be factors influencing the rate of functional maturation of cortical cells. The intracortical synaptic delay was estimated for each of the cells driven mono-synaptically from the LGN. The average delay decreased most rapidly during the 4th and 5th week. Conduction velocities of afferents innervating the mono-synaptic cells in layers IVab and IVc were calculated. The velocity of the former afferents increased very quickly and reached a value suggesting myelination at 4 weeks, while that of the latter afferents at 5 weeks. Since each type of LGN cell is known to project segregatedly to layers IVab and IVc, respectively, this suggests that Y-cells of LGN may mature earlier than X-cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208604
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of early monocular deprivation on development of cortico-geniculate projections in the cat (1981)
    Springer
    Experimental brain research 43 (1981), S. 451-454 
    Details
    ISSN: 1432-1106
    Keywords: Monocular deprivation ; Cortico-geniculate projections ; Visual cortex ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 16 cats monocularly deprived from 2 to 3 weeks of age, we studied 53 striate cortical cells which were identified as projecting to the dorsal lateral geniculate nucleus (LGN) on the basis of antidromic activation from LGN and of histological localization within cortical layer VI. As in the normal cat, these cortico-geniculate cells could be classified as slow, intermediate or fast, according to their axonal conduction velocities. The sampling ratio of the slow cells (mostly unresponsive to visual stimuli) was much higher than normal. On the other hand, the ratio of the intermediate (one half were simple cells) and fast cells (all except one were complex cells) was significantly lower than the norm. Also, the average axonal conduction velocities of the complex and simple cells were significantly slower than normal. These results suggest that normal maturation of cortico-geniculate cells, particularly fast and intermediate ones, is retarded or arrested by monocular visual deprivation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238390
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  • 3
    Electronic Resource
    Electronic Resource
    Single agent therapy of interferon for brain tumours: Correlation between natural killer activity and clinical course (1984)
    Springer
    Acta neurochirurgica 73 (1984), S. 13-23 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumour ; interferon ; natural killer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The anti-tumour effect of mouse interferon (IFN) on an intracranially transplanted 203-glioma in C 57 BL mice and the natural killer (NK) activity of spleen cells were studied. As a clinical trial, five patients with glioblastomas were treated with human fibroblast IFN and the anti-tumour effect of IFN and the NK activity of peripheral blood lymphocytes were also studied. The NK activity increased after the beginning of IFN therapy but there was no remarkable antitumour effect of IFN in both mouse and human studies. There was no marked correlation between the increased NK activity and the anti-tumour effect of IFN in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401780
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  • 4
    Electronic Resource
    Electronic Resource
    Gross dissection and immunohistochemical studies on branch fusion type of ventral and dorsal pancreatic ducts: A case report (1991)
    Springer
    Surgical and radiologic anatomy 13 (1991), S. 333-337 
    Details
    ISSN: 1279-8517
    Keywords: Ventral and dorsal pancreas ; Branch fusion of pancreatic duct ; Ansa pancreatica ; Pancreatic polypeptide (PP) cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Un cas d'anastomose entre les canaux pancréatiques ventral et dorsal par l'intermédiaire de deux branches inférieures a fait l'objet d'une étude à la fois macroscopique et immuno-histochimique, basée sur l'organogénèse du pancréas. Radiologiquement, l'anastomose semblait être constituée par une branche inférieure du conduit pancréatique ventral et une branche inférieure du conduit pancréatique dorsal. La cartographie des cellules pancréatiques polypeptidiques dans le matériel obtenu par duodéno-pancréatectomie, a permis de constater que la branche anastomotique était une branche du conduit pancréatique dorsal. Ainsi, il s'agissait non pas d'une anastomose entre deux branches inférieures, mais d'une anastomose entre une branche inférieure du conduit pancréatique dorsal et le conduit pancréatique ventral. La notion d'anse pancréatique est remise en question par les auteurs.
    Notes: Summary A case of fusion via two inferior branches between the ventral and dorsal pancreatic ducts was studied both macroscopically and immunohistochemically, based on the organogenesis of the pancreas. Radiologically, the branch fusion seemed to be composed of an inferior branch of the ventral pancreatic duct and an inferior branch of the dorsal pancreatic duct. By mapping pancreatic polypeptide cells in the material obtained by pancreatoduodenectomy, however, the branch was identified as a branch of the dorsal pancreatic duct. Thus, fusion between two inferior branches was not established, but was found to consist of an inferior branch of the dorsal pancreatic duct connected with the ventral pancreatic duct. We therefore challenge the concept of the ansa pancreatica.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01627768
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  • 5
    Electronic Resource
    Electronic Resource
    Possible mechanism of regulating adenylate cyclase activity in adipocyte membranes from exercise-trained male rats
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 151 (1988), S. 1262-1298 
    Details
    ISSN: 0006-291X
    Keywords: [abr] BSA; bovin serum albumin ; [abr] CT; cholera toxin ; [abr] IAP; islet-activating protein, a pertusis toxin ; [abr] IBMX; 3-isobutyl-1-methylxantine ; [abr] N; N"s and N"i are guanine nucleotide regulatory protein, its ; [abr] β-AR; β-adrenergic receptor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(88)80502-3
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  • 6
    Electronic Resource
    Electronic Resource
    Possible mechanism of regulating adenylate cyclase activity in adipocyte membranes from exercise-trained male rats
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 151 (1988), S. 1262-1298 
    Details
    ISSN: 0006-291X
    Keywords: [abr] BSA; bovin serum albumin ; [abr] CT; cholera toxin ; [abr] IAP; islet-activating protein, a pertusis toxin ; [abr] IBMX; 3-isobutyl-1-methylxantine ; [abr] N; N"s and N"i are guanine nucleotide regulatory protein, its ; [abr] β-AR; β-adrenergic receptor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(88)80502-3
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A yeast protein, homologous to the proteolipid of the chromaffin granule proton-ATPase, is important for cell growth
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 168 (1990), S. 574-579 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(90)92359-8
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  • 8
    Electronic Resource
    Electronic Resource
    Foamy cell aggregation in duodenal diverticula (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 29 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have investigated 44 cases of duodenal diverticulum to delineate the pathological features. Foamy cell aggregations were observed in 24 (54.5%) of the cases. The foamy cells were located within the submucosa in all 24 cases and were found around the deepest portion of the diverticula in 14. There were no statistically significant differences between the depth of the diverticulum and the presence or degree of foamy cell aggregation. Lymphoid aggregates, focal thickening of the muscularis mucosae, submucosal fibrosis, intimal thickening of submucosal vessels and submucosal haemorrhage were also detected, but statistical analysis showed no significant associations between these pathological findings and the presence of foamy cell aggregates. We conclude that the foamy cell aggregates are a non-specific but frequent pathological finding in duodenal diverticula and which have not been described in previous studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1996.tb01402.x
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  • 9
    Electronic Resource
    Electronic Resource
    Small vessel vasculitis limited to pleuropulmonary manifestations, possibly induced by endotoxin (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 43 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  We investigated a rare case of small vessel vasculitis (SVV) limited to pleuropulmonary manifestations, possibly induced by endotoxin, to determine the activation of immuno-mediated cells and endothelia in the pleuropulmonary circulation.Methods and results:  A 44-year-old man with a high fever was X-rayed, revealing bilateral pleural effusion and atelectasis in the chest. His laboratory data were within normal limits except for a high white blood cell count and a high C-reactive protein level. Autoantibodies including anti-neutrophil cytoplasmic antibody were negative. Endotoxin was detected in his sera, but repeated cultures of sputa, urine, blood and the pleural effusion were negative for bacteria. Video-assisted thoracic surgery was performed and lung and parietal pleura specimens were obtained. Histology showed arterioles or small arteries infiltrated by monocytes or neutrophils with fibrinoid necrosis and acute or chronic venulitis. A diagnosis of SVV in the lung and pleura was made. Immunohistochemistry revealed that interleukin (IL)-1β was expressed in monocytes and vascular cell adhesion molecule (VCAM)-1 on endothelial cells in the vasculitic lesions in the lung.Conclusions:  Endotoxin possibly induced the inflammation in this apparently unique case of pleuropulmonary small vessel vasculitis. Immunohistochemistry revealed the expression of IL-1β and VCAM-1 which may have caused activation of monocytes and endothelial cells within the vasculitic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01662.x
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  • 10
    Electronic Resource
    Electronic Resource
    Duodenal wall cysts may be derived from a ductal component of ectopic pancreatic tissue (2002)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 41 (2002), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims: To clarify the mechanism of origin of duodenal wall cysts in patients with chronic pancreatitis, developing into duodenal stenosis.Methods and results: Specimens from 12 pancreatoduodenectomized patients with chronic pancreatitis and 51 controls were studied histopathologically and immunohistochemically. Variously shaped cystic lesions, averaging about 15 mm in diameter, were found in the duodenum in six of the 12 patients with chronic pancreatitis, but were not observed in the controls. Each case had an average of two cysts, which were located mainly in the muscularis propria of the duodenum with or without submucosal or extraduodenal–peripancreatic extensions. The inner part of the cyst wall consisted of a moderate rim of granulation tissue, with both myofibroblasts and smooth muscle proliferation in the tissue surrounding the cyst and the submucosal layer of the duodenum, occasionally accompanied by an epithelial lining. A ductal structure in the muscularis propria of the duodenum, possibly a ductal component of ectopic pancreatic tissue, was found in five of the six cases. Some of these structures showed cystic changes. Three of the six patients had accompanying duodenal stenosis.Conclusions: Duodenal wall cysts occur mainly in the muscularis propria of the duodenum associated with both myofibroblasts and smooth muscle proliferation, and may result in duodenal stenosis. These cysts may be derived from a ductal component of ectopic pancreatic tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2002.01453.x
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