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  • 1
    Electronic Resource
    Electronic Resource
    Designing with a Responsive Colour Palette: The Development of Colour and Pattern Changing Products (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 60 (Sept. 2008), p. 26-31 
    Details
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: This paper presents an illustrated discussion of the potential for creative design applications ofthermochromic textiles brought into contact with specifically designed heat-profiling circuitry. Theresults are derived from a current research programme at the design/technology interface on theapplication of colour change technology in interior textile design. Examples are given of textilesamples combining printed thermochromics with circuitry to demonstrate the aesthetic qualities thatcan be achieved from integration of the technologies in a flexible fabric system. Dynamic colourchange effects controlled by prototype circuitry and power electronics are demonstrated. The paperconcludes with an analysis of the potential for product/artefact development in the area of “smart”design and how, as a consequence, a responsive interior might be envisaged
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.60.26.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Follow-Up Strategies in the Postirradiated Breast: Techniques Involved in the Detection of Local Recurrences Following Breast Conservation Therapy (1996)
    Oxford, UK : Blackwell Publishing Ltd
    The @breast journal 2 (1996), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Our goal was to delineate parameters involved in the detection of local recurrences of cancer after breast conservation therapy, and to further define standardized follow-up strategies for surveillance of the breast after irradiation. We retrospectively evaluated 152 patients treated with breast conservation therapy who had received a median of 86 months of consecutive clinical and radiographic follow-up at the University of Texas M. D. Anderson Cancer Center from 1978 to 1989. All mammograms were reevaluated by a single radiologist (B. S. J who had no knowledge of the physical or pathologic findings.Local recurrences were found in 13 patients (9%), with a mean time to recurrence of 51 months (median time, 37 months). Age, tumor size, margin status, nuclear grade, estrogen receptor status, nodal status, and the presence of ex-tranodal extension were similar in patients with or without local recurrence. The primary method of detection was physical examination in 10 of the 13 patients (77%); only 3 occult local recurrences were detected by mammography alone. The 13 patients with local recurrences underwent an aver-age number of 14 physical examinations and 5 mammograms in the follow-up period prior to the detection of local recurrence.Our data suggested that, in patients with early stage breast cancer, the incidence of local recurrence after breast conservation therapy is relatively low. Most local recurrences occurred 2 years after breast conservation therapy and were detected by physical examinations. Yearly diagnostic mammograms after breast conservation therapy are sufficient and may complement thorough physical examinations. A new baseline mammogram to evaluate the treated breast at 6 months, after irradiation changes have stabilized, may be useful for future mammogram comparisons.?
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1524-4741.1996.tb00125.x
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  • 3
    Electronic Resource
    Electronic Resource
    Diet, bacteria and colonic cancer (1999)
    Bingley : Emerald
    Nutrition & food science 99 (1999), S. 187-193 
    Details
    ISSN: 0034-6659
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The links between diet, bacteria and colonic cancer are examined in this article. Studies suggest that high intakes of fat and protein are associated with elevated risk of colonic cancer whereas cereals, fruits and vegetables seem to be protective. A further aspect considered in relation to this type of cancer is metabolism by gut bacteria. Probiotics, prebiotics and synbiotics are presented as ways of stimulating the activities, certain gut flora and the use of "functional foods" is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00346659910270945
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  • 4
    Electronic Resource
    Electronic Resource
    Phase II study of aziridinylbenzoquinone (AZQ) in patients with central nervous system malignancies: a Southwest Oncology Group study (1985)
    Springer
    Journal of neuro-oncology 3 (1985), S. 131-135 
    Details
    ISSN: 1573-7373
    Keywords: AZQ ; carbamic acid ; central nervous system malignancies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary AZQ, an alkylating agent with lipophilic characteristics allowing CNS penetration was studied in patients with primary CNS malignancies refractory to surgical and radiotherapeutic modalities. Responses were evaluated by three criteria: neurologic examination, performance status and CT scan of the brain. Improvement in all three parameters with stable or decreasing doses of decadron was required for a partial response. Thirty-six poor risk (prior chematherapy) patients with Grades III and IV astrocytomas were treated with 30 mg/m2. Three patients had a partial response (14, 17, 60 weeks duration). Two patients had mixed responses (worsening of one disease parameter with improvement in another), four had stable disease and one patient had improvement in neurologic parameters with a stable CT scan. Twenty-six patients had increasing disease. Fifteen good risk patients (no prior chemotherapy) with recurrent grades III and IV astrocytomas were treated at a dose of 40 mg/m2 intravenously every three weeks. There were no objective responses in this group of patients. Three patients with nonastrocytomas were treated and no responses observed. The drug was well tolerated. Myelosuppression in the form of leukopenia and thrombocytopenia was the major toxicity. Myelosuppression required dose reductions in eight patients and discontinuation of therapy due to repeated treatment delays in two patients. AZQ at doses of 30 and 40 mg/m2 given on an intermittent bolus schedule is inactive in patients with Grades III and IV recurrent astrocytoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02228889
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  • 5
    Electronic Resource
    Electronic Resource
    Local Recurrence and Survival Among Black Women With Early-Stage Breast Cancer Treated With Breast-Conservation Therapy or Mastectomy (1999)
    Springer
    Annals of surgical oncology 6 (1999), S. 241-248 
    Details
    ISSN: 1534-4681
    Keywords: Black women ; Breast cancer ; Breast-conservation therapy ; Local recurrence ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Black women with breast cancer have significantly worse survival rates and receive diagnoses at relatively younger ages, compared with white patients with breast cancer, in the United States. Young age at diagnosis has been associated with increased risk for local recurrence (LR) after breast-conservation therapy (BCT). The goal of this study was to evaluate the impact of age and BCT on LR and survival rates among black patients with breast cancer. Methods: The records for 363 black women treated for breast cancer (excluding stage IV disease) at a comprehensive cancer center were reviewed. Results: Fifty-eight percent of patients (n = 211) had tumors ≤5 cm in diameter. Forty-two of these patients (19.9%) received BCT; the LR rate for this group was 9.8%. A total of 168 patients (79.6%) underwent mastectomy; the LR rate for this group was 8.9%. Data on the primary operation were unavailable for one patient. Five-year disease-free survival rates were similar for patients treated with BCT and those treated with mastectomy (88% and 73%, respectively). LR was associated with significant decreases in 5-year overall survival rates for both the BCT group (67% vs. 95%, P 〈 .01) and the mastectomy group (43% vs. 76%, P 〈 .01). LR and 5-year diseasespecific survival rates were similar for patients 〈50 years of age and patients ≥50 years of age, regardless of treatment. Conclusions: LR and survival rates are not compromised by the use of BCT among black American patients. LR is associated with an increased risk of breast cancer death, regardless of treatment type. Younger age at diagnosis was not associated with an increased rate of LR after BCT in this series.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-999-0241-y
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  • 6
    Electronic Resource
    Electronic Resource
    Phase II evaluation of echinomycin (NSC-526417) in patients with central nervous system malignancies (1993)
    Springer
    Journal of neuro-oncology 15 (1993), S. 181-184 
    Details
    ISSN: 1573-7373
    Keywords: echinomycin ; central nervous system malignancies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective of this trial was to determine the efficacy of echinomycin (1.2mg/m2) administered on a weekly times four schedule in the treatment of patients with recurrent or progressive central nervous malignancies despite adequate radiotherapy. Thirty-five patients were registered on study. The majority of patients (20) had glioblastoma multiforme. Ten had anaplastic astrocytoma. Eight patients had received prior nitrosoureas. SWOG performance status was 1 in 11 patients and 2 in 22. The median age was 51 years (25–75 years). One patient had a partial remission (3%:95% confidence interval: 1%–16%). Twenty two patients had progressive disease. The median survival was 5.9 months. Toxicity was primarily gastrointestinal with nausea and vomiting in 13 patients and nausea only in 11 patients. Hepatotoxicity occurred in 10 patients. Echinomycin given at this dose and schedule is not effective in treating patients with recurrent or progressive glioblastoma multiforme or anaplastic astrocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01053939
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  • 7
    Electronic Resource
    Electronic Resource
    Whole brain irradiation and intrathecal Methotrexate in the treatment of solid tumor leptomeningeal metastases — A Southwest Oncology Group study (1988)
    Springer
    Journal of neuro-oncology 6 (1988), S. 107-112 
    Details
    ISSN: 1573-7373
    Keywords: leptomeningeal carcinomatosis ; intrathecal methotrexate ; whole brain irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 1981 through 1985 the Southwest Oncology Group (SWOG) conducted a study evaluating the natural history and the effectiveness of standard therapy in those patients with leptomeningeal carcinomatosis from non-hematologic malignancies. Twenty-six patients were evaluated for the effectiveness of treatment; those who responded to therapy by one month exhibited a median additional survival of 5.7 months and those who were not responders at one month exhibited a median additional survival of 1.8 months. We were unable to identify pre-treatment clinical characteristics which would predict for a favorable response to therapy. Aggressive treatment in some patients may be indicated, as those patients who respond to treatment may have a survival benefit. The overall prognosis in this patient group remains exceedingly poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327385
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  • 8
    Electronic Resource
    Electronic Resource
    New agents in the treatment of primary brain tumors (1994)
    Springer
    Journal of neuro-oncology 20 (1994), S. 141-153 
    Details
    ISSN: 1573-7373
    Keywords: central nervous system tumors ; new agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A review of single agent trials of cytotoxic agents in adults with high grade gliomas is presented. The rationale for testing these agents in patients with brain tumors was variable and is discussed. The criteria to evaluate responses were also variable ranging from subjective evaluation of clinical improvement with a stable radiographic assessment to the same objective response criteria utilized for solid tumors. Trials of agents specifically designed for brain tumors such as AZQ and spiromustine have been disappointing. There are encouraging results being seen in early trials of newer agents which await confirmation in larger trials but which hold promise for improving the disappointing results seen so far with chemotherapy in primary brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01052724
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  • 9
    Electronic Resource
    Electronic Resource
    Differential solubility of subcomponents of rat glomerular basement membrane (1984)
    Springer
    Bioscience reports 4 (1984), S. 319-326 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Marked differences were found in the electrophoretic profiles and amino-acid compositions of components prepared from rat glomerular basement membrane (GBM) by a number of different solubilization procedures. Treatment with reducing agent resulted in a simplified electrophoretic pattern which was characterized by the presence of a major collagenous component with a mol.wt, of 150 000. In contrast, detergent solubilized mainly lower-mol.-wt, material which had a more polar amino-acid composition. When both reagents were used together the majority of the basement-membrane material was soJubilized within 2 h and components with mol.wts, of 170 000 and 135 000 were predominant i n the pro-α region of the gel. Treatment for a further 16 h was required to solubilize higher-mol.-wt, material and to achieve maximum solubility of components in the pro-α region with mol.wts, of 185 000 and 150 000. These methods provide a means of separating subcomponents of rat GBM while avoiding the problems of degradation inherent in enzymatic procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01140495
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  • 10
    Electronic Resource
    Electronic Resource
    A Southwest Oncology Group phase II evaluation of fluderabine monophosphate in sarcoma (1994)
    Springer
    Investigational new drugs 12 (1994), S. 259-261 
    Details
    ISSN: 1573-0646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873969
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