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  • 1
    Electronic Resource
    Electronic Resource
    Survey of urine from transplant recipients for polyomaviruses JC and BK using the polymerase chain reaction
    Amsterdam : Elsevier
    Molecular and Cellular Probes 5 (1991), S. 125-128 
    Details
    ISSN: 0890-8508
    Keywords: BK virus ; JC virus ; polymerase chain reaction ; polyomavirus ; transplantation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0890-8508(91)90006-6
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular Epidemiology of Tuberculosis among HIV-Infected Persons in Switzerland: A Countrywide 9-Year Cohort Study (1999)
    Springer
    Infection 27 (1999), S. 323-330 
    Details
    ISSN: 1439-0973
    Keywords: Key words IS6110 ; DNA fingerprinting ; Molecular epidemiology ; Tuberculosis ; Transmission ; HIV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated tuberculosis transmission during a nine-year period (1988–1996) in an countrywide community-based cohort of HIV-infected persons in Switzerland (the Swiss HIV Cohort Study [SHCS]). We estimated the proportion of tuberculosis cases due to reinfection and relapse, and assessed factors which may increase the risk of tuberculosis transmission. HIV-infected persons were followed prospectively and molecular fingerprinting with insertion sequence (IS) 6110, 36-bp direct repeat, and IS6110-PCR was used to determine M. tuberculosis case clustering. Out of 7999 SHCS participants, 267 persons developed tuberculosis. 158 M. tuberculosis isolates from 138 patients were available for study. Molecular analysis identified 33 (24%) episodes of tuberculosis associated with 12 clusters including 2 to 8 patients. Two patients experienced reinfection, and nine had a relapse. Detailed contact investigation identified definite or possible epidemiological links between 21 of 33 cluster patients (64%). Multivariate logistic regression analysis did not identify any risk marker significantly associated with clustering. During a nine-year period, one fourth of tuberculosis case were grouped in clusters within a selection of 138 HIV-infected patients. This may represent the lowest estimation of recently acquired tuberculosis infection. There were no large institutional on community outbreaks among HIV-infected participants of the Swiss HIV Cohort Study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s150100050037
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular diagnostics for infectious diseases: where do we stand? (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 415-416 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180513
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of the relatedness of strains ofMycobacterium avium using pulsed-field gel electrophoresis (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 212-217 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The application of molecular techniques to investigate strain relatedness may help define the local epidemiology ofMycobacterium avium infection, and, by identifying false isolates (i.e. neither pathogens nor colonizers) resulting from contamination, may serve as a tool for quality control in the laboratory. For this purpose, isolates from all patients (n=129) withMycobacterium avium infections identified over a two-year period were investigated by pulsed-field gel electrophoresis (PFGE). Of 38 PFGE patterns identified, 34 corresponded to unique strains or to isolates present in no more than two or three individuals. One prevalent strain was identified among HIV-infected patients and three patterns were related to culture contamination events. PFGE (i) established the diversity ofMycobacterium avium strains in a community; (ii) identified the existence of a unique strain that may account for one-fifth ofMycobacterium avium isolated from HIV-infected patients locally; (iii) documented the extent and resolution of a suspected pseudo-outbreak; and (iv) uncovered an additional unsuspected contamination event.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02310358
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Fungal blood cultures (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 825-831 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is generally accepted that fungemia is an important and often life-threatening event. Unfortunately, it often remains undetected due to the lack of physician and/or laboratory awareness of the usefulness of fungal blood cultures. Many laboratories do not offer the possibility of performing fungal blood cultures and, if offered, some use methods that are not optimal for recovery or require extended incubation for recovery. Of the methods considered satisfactory, the lysis-centrifugation method (Isolator) has the highest recovery rate and the shortest recovery time. The Bactec and Septi-Chek systems are alternative methods, but have limitations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02185855
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  • 6
    Electronic Resource
    Electronic Resource
    Detection of JC virus by polymerase chain reaction in cerebrospinal fluid from two patients with progressive multifocal leukoencephalopathy (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 253-254 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The polymerase chain reaction (PCR) was used to identify JC virus (JCV) in the cerebrospinal fluid of two patients with progressive multifocal leukoencephalopathy confirmed by brain biopsy. In addition, JCV viremia was demonstrated by PCR in one case. JCV detection in spinal fluid by PCR may be the first non-invasive technique available for the diagnostic confirmation of progressive multifocal leukoencephalopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098091
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus infection in HIV-positive patients (1993)
    Springer
    European journal of clinical microbiology & infectious diseases 12 (1993), S. 601-609 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between Epstein-Barr virus (EBV) viral load in peripheral blood and HIV infection was determined in 103 HIV-infected patients. Epstein-Barr virus was detected by polymerase chain reaction in 75 % of the patients, 21 % of whom had the more uncommon EBV subtype 2. The highest levels of EBV were found in patients with 100–400 CD4+ cells/mm3 and not in those with more profound immunosuppression. An association was identified between EBV load and HIV proviral levels (p〈0.0001), an IgM response to EBV early antigens (p≤0.01) and p24 antigenemia (p〈0.01 in patients with 〉 100 CD4+ cells), but not with other clinical or laboratory parameters. Combinations of different EBV and HIV parameters identified a subgroup of patients with a 2.2- to 4.8-fold risk of ≥ 35 % decline in CD4+ counts over six months. The association between EBV and HIV markers may reflect a significant pathogenic interaction between the two viruses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973638
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    Paper (German National Licenses)
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