Electronic Resource
Springer
European journal of clinical microbiology & infectious diseases
12 (1993), S. 601-609
ISSN:
1435-4373
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The relationship between Epstein-Barr virus (EBV) viral load in peripheral blood and HIV infection was determined in 103 HIV-infected patients. Epstein-Barr virus was detected by polymerase chain reaction in 75 % of the patients, 21 % of whom had the more uncommon EBV subtype 2. The highest levels of EBV were found in patients with 100–400 CD4+ cells/mm3 and not in those with more profound immunosuppression. An association was identified between EBV load and HIV proviral levels (p〈0.0001), an IgM response to EBV early antigens (p≤0.01) and p24 antigenemia (p〈0.01 in patients with 〉 100 CD4+ cells), but not with other clinical or laboratory parameters. Combinations of different EBV and HIV parameters identified a subgroup of patients with a 2.2- to 4.8-fold risk of ≥ 35 % decline in CD4+ counts over six months. The association between EBV and HIV markers may reflect a significant pathogenic interaction between the two viruses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01973638
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