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  • 1
    Electronic Resource
    Electronic Resource
    Sequence analysis of elastin cDNA from chick aorta and tissue-specific transcription of the elastin gene in developing chick embryo
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 256 (1987), S. 455-461 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(87)90602-3
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histological increase in inflammatory infiltrate in sun-exposed skin of female subjects: the possible involvement of matrix metalloproteinase-1 produced by inflammatory infiltrate on collagen degradation (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate morphological changes occurring during cutaneous photoageing, a correlation between the number of infiltrating cells in the dermis and the degree of collagen damage was examined using sections from clinically normal chronically sun-exposed and sun-protected skin of Japanese female subjects. Haematoxylin and eosin-stained sections from 134 sun-exposed (subjects aged 3–82 years) and 73 sun-protected (subjects aged 1–86 years) areas demonstrated a predominant lymphoid cell and to a lesser extent histiocyte infiltration. The mean ± SD number of lymphoid cells and histiocytes in the sun-exposed skin sections (427·0 ± 192·2 and 147·8 ± 83·3 cells/mm2, respectively) was significantly higher than in the sun-protected skin sections (292·6 ± 98·3 and 125·9 ± 59·0 cells/mm2, respectively) (P 〈 0·001 and P 〈 0·05, respectively), and the number of lymphoid cells in the sun-exposed skin sections increased significantly with age up to 50 years (r = 0·400, P 〈 0·001). Sun-exposed skin sections with severe collagen degeneration had a significantly higher number of lymphoid cells than those with slightly degenerated collagen (mean 626·3 vs. 482·4 cells/mm2, P 〈 0·01). The mean count of mast cells in sun-exposed skin was 202·0 cells/mm2; this did not vary with the age of the subjects or the level of collagen damage. Immunohistochemical studies using 24 frozen sections identified most of the lymphoid cells infiltrating sun-exposed skin as memory T lymphocytes (CD3+, CD4+ and CD45RO+). The number of cells which displayed immunoreactivity to matrix metalloproteinase (MMP)-1 in the sun-exposed skin sections was significantly higher than in the sun-protected skin sections (mean 170·2 vs. 113·6 cells/mm2, P 〈 0·05). Among these cells were observed CD3 and MMP-1 double-stained T lymphocytes, and T lymphocytes contacting MMP-1-positive cells. These morphological observations suggest that T lymphocytes infiltrating photodamaged skin may play a part in the degeneration and reduction of collagen through MMP-1 activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03296.x
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  • 3
    Electronic Resource
    Electronic Resource
    Theory of Brdicka current and the dependence of the current on cobalt ion concentration
    Amsterdam : Elsevier
    Bioelectrochemistry and Bioenergetics 9 (1982), S. 253-263 
    Details
    ISSN: 0302-4598
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0302-4598(82)80015-9
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  • 4
    Electronic Resource
    Electronic Resource
    Elastin synthesis is inhibited by angiotensin II but not by platelet-derived growth factor in arterial smooth muscle cells
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1207 (1994), S. 68-73 
    Details
    ISSN: 0167-4838
    Keywords: Angiotensin II ; Elastin ; Platelet-derived growth factor ; Smooth muscle cell
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(94)90052-3
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  • 5
    Electronic Resource
    Electronic Resource
    478-Theory of Brdicka current and the dependence of the current on cobalt ion concentration
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 141 (1982), S. 253-263 
    Details
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0728(82)85212-1
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  • 6
    Electronic Resource
    Electronic Resource
    Improvement of macromolecular clearance via lymph flow in hamster gingiva by topical warming and massage (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of periodontal research 35 (2000), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The lymphatic system is very important for macromolecular clearance in various tissues, especially in the gingiva. However, the kinetics of macromolecular clearance via the lymph flow in the gingiva are poorly understood. The aim of this study was to investigate whether thermal or mechanical stimulation affects macromolecular clearance via the lymph flow in the gingiva. Carbon black suspension was injected into the mandibular gingiva of anesthetized hamsters and its drainage into cervical lymph nodes was examined. Clearance of 14C-methylated bovine albumin and tritiated water from the gingiva and their drainage into submandibular lymph nodes and blood was quantified. The effect of topical warming or massage on clearance of 14C-methylated albumin from the gingiva during a 15 min period was examined. In addition, the influence of neurochemical antagonists on the stimulatory effect of topical warming on albumin clearance was investigated. Submandibular lymph nodes were clearly delineated by carbon black 10 min after the injection. More radiolabeled albumin appeared in submandibular lymph nodes than in serum, while more tritiated water appeared in serum. Topical warming (45°C, 2 min) and warming plus massage (with a silicon rubber brush, 20 s) decreased the radiolabeled albumin in the gingiva 15 min after the injection. There was less radiolabeled albumin in the gingiva after gingival warming plus massage than after warming. Previous injection of HOE140 or propranolol into the gingiva diminished the stimulatory effect of topical warming on albumin clearance. It was concluded that topical warming plus massage improves macromolecular clearance via the lymph flow in hamster gingiva.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0765.2000.035005310.x
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  • 7
    Electronic Resource
    Electronic Resource
    Relationship between covalently bound ceramides and transepidermal water loss (TEWL) (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 463-468 
    Details
    ISSN: 1432-069X
    Keywords: Key words Covalently bound ceramides ; TEWL ; Lamellar ; UVB ; EFAD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unbound and can be extracted by organic solvents, but some intercellular lipids are covalently bound to cornified envelope proteins. Decreases in unbound lipid levels reduce the barrier function of the stratum corneum, but the relationship between bound lipid and the barrier function of the stratum corneum is not well understood. In this study, we examined the relationship between the amount of covalently bound ceramide, the main bound lipid, and the barrier function of the stratum corneum. A single dose of UVB irradiation (2 × MED), or continuous UVB irradiation (0.5 × MED/day for 14 days) to the back, or feeding with an essential fatty acid-deficient (EFAD) diet for ¶8 weeks caused a significant elevation of TEWL and a significant reduction in covalently bound ceramides in hairless rats. Transmission electron microscopy revealed that the intercellular multilamellar structures in the stratum corneum of treated rats were incomplete (folding, defects, unclear images) compared to the structures seen in the stratum corneum of non-UVB-irradiated and non-EFAD rats. These results suggest that the amount of covalently bound ceramides is highly correlated with the barrier function of the skin, and that covalently bound ceramides play an important role in the formation of lamellar structures, and are involved in the maintenance of the barrier function of the skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000160
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