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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 821-825 
    ISSN: 1432-1440
    Keywords: Crohn's disease ; Tube feeding ; Nutritional therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tube feeding (TF) with elemental diets was used as primary therapy in 25 patients with an acute phase of Crohn's disease (CD). Feed was infused continuously via a nasoduodenal tube in a dosage of 2600–3200 kcal/day. The Crohn's disease activity index (CDAI), the serum levels of a1-antitrypsin, C-reactive protein (CRP) and haptoglobin were used as parameters for disease activity; the body weight and the serum levels of albumin, prealbumin and transferrin were parameters for the nutritional status. Disease activity could be reduced in the total group by TF shown by a reduction of CDAI from 269±72 to 174±103, a1-antitrypsin from 449±160 to 378±147 mg/dl, CRP from 6.12±5.6 to 3.23±5.4 mg/dl and haptoglobin from 414±167 to 344±152 mg/dl. Nutritional status was improved (body weight 83±12% to 87±10% ideal body weight, prealbumin 20.2±7.7 to 29.7±9.5 mg/dl, and transferin 229±107 to 310±103 mg/dl). Albumin did not change significantly. In 15 patients the CDAI was reduced to levels below 150. These patients were characterized as responders. In ten patients a normalization of CDAI could not be achieved and therapy had to be changed. With a stepwise linear discriminant analysis it could be demonstrated that patients with colonic disease and fever do not react to TF, with a probability of 90%. We conclude that TF can be used as primary therapy for the acute phase of CD in patients with small bowel disease. In patients with colonic disease and fever it is not as effective.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We investigated whether patients with contact allergy differed from non-contact-allergic, non-atopic controls with regard to genotype and phenotype of the polymorphic enzyme N-acetyltransferase 2 (NAT2). 55 contact-allergic patients recruited from the Information Network of Departments of Dermatology (IVDK) were compared to 85 controls from among local health care personnel. NAT2 activity was calculated from HPLC analysis of the ratio of the caffeine metabolites 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 1-methylxanthine (1MX) in the urine. NAT2 genotype was determined by polymerase chain reaction (PCR). A statistically significantly increased proportion of rapid acetylators was found in contact-allergic patients. This may have 2 possible implications: acetylation may enhance contact sensitization; or NAT2 status may be a genetic marker for contact sensitizability.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 66 (1989), S. 2430-2436 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated the origin and effects of carbon in semi-insulating GaAs grown by the low-pressure liquid encapsulated Czochralski (L-LEC) technique. The carbon concentration in the seed portion of boules grown from dry B2O3 was found to depend on the delay time between completion of melt compounding and solidification of the seed segment. This behavior for carbon with delay time after compounding demonstrates that the predominant source of carbon in L-LEC crystals is the initial charge material and not the puller ambient or graphitic parts. Effects of carbon on the transport properties of as-grown L-LEC are also observed and discussed. Comparisons are made between measured electrical properties and those calculated from carrier statistics and scattering theory. In addition, the effects of carbon on thermal stability and ion implantation behavior of this material is assessed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0014-5793
    Keywords: (Escherichia coli) ; 3'-Phospho-adenylylsulfate reductase ; Gene product ; PT7 expression ; Phenotypic complementation ; cys H DNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron 30 (1974), S. 221-223 
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron 29 (1973), S. 2937-2941 
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron 25 (1969), S. 5199-5203 
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron 34 (1978), S. 2701-2704 
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Atopic dermatitis (AD) and psoriasis are genetically determined inflammatory skin disorders characterized by abnormal cytokine production. From association studies there is evidence that functionally relevant cytokine gene polymorphisms contribute to the genetic basis of psoriasis. Association studies in AD have mostly been limited to polymorphisms of T-helper 2-type cytokines, which dominate in acute AD lesions. Unexpectedly, the results of recent genome scans indicate linkage of AD to psoriasis susceptibility loci. Therefore, AD may also be influenced by genes that modulate cutaneous inflammation independently from atopic mechanisms. Objectives To investigate further the role of cytokine gene polymorphisms in AD. Methods Polymorphisms in the genes encoding tumour necrosis factor-α (TNFA−238 G/A, −308 G/A), interleukin (IL)-1β (IL1B−511 T/C, +3953 T/C), IL-6 (IL6−174 C/G), IL-10 (IL10−1082 A/G) and the IL-1 receptor antagonist (IL1RN intron 2) were investigated in German patients with AD (n = 94) and in healthy nonatopic individuals (n = 214) by polymerase chain reaction-based methods and direct cycle sequencing. Results No association was found between AD and any of the polymorphisms analysed. This is in contrast to the recently described association between psoriasis and the TNFA−238 and IL1B−511 polymorphisms. Conclusions Our data indicate that cytokine gene polymorphisms may act as specific markers of inflammatory skin diseases rather than contribute to a general disposition towards cutaneous inflammation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 57 (1986), S. 259-265 
    ISSN: 1432-1246
    Keywords: Epidemiology ; Hepatitis B ; Health service
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present investigation of occupation-related cases of hepatitis in the statistics of occupational diseases attempted to quantify the specific risk of this infectious disease for all occupations within the health service. The absolute number of occupation-related cases of hepatitis B increased fourfold over the last two decades, while at the same time the number of health service employees only doubled. In comparison with the Austrian population, the hepatitis risk is about 11 times higher for the health service employees. Especially laboratory personnel, doctors and support service personnel are exposed to these increased risks. The relative risks according to age, sex and type of occupation were also investigated and a comparison was made with the findings of other investigations in Austrian and international specialized literature. First information is also given about the findings of the screening on immunity against HBs antigen, anti-HBS and anti-HBc in the professional group of health service employees. The calculations, and also experience in other countries, show the need for the introduction of an active protective immunization against hepatitis B for all health service employees. The prophylaxis against hepatitis that was begun in Austria on January 1st, 1983, is the first extensive vaccination programme against this liver disease, that on the basis of research done by a social security institute, has been implemented free of charge by this institute for a professional category.
    Type of Medium: Electronic Resource
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