ISSN:
1365-2036
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Conventional 13C-urea breath testing (13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To investigate a new 13C-UBT protocol without a test meal in a Chinese population.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the ‘gold standard’ (CLO test and histology).〈section xml:id="abs1-4"〉〈title type="main"〉Results:Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
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