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  • 1
    Electronic Resource
    Electronic Resource
    31P kernspinspektroskopie der magenwand nach proximaler selektiver vagotomie (1990)
    Springer
    Langenbeck's archives of surgery 375 (1990), S. 205-207 
    Details
    ISSN: 1435-2451
    Keywords: Proximal selective vagotomy ; Metabolism of the gastric wall ; 31P-NMR spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Experiment wurde der Einfluß der SPV auf den Phosphatmetabolismus der Magenwand bei Ratten mittels 31P-NMR Spektroskopie untersucht. Die SPV bewirkt unmittelbar nach der Operation eine Destruktion des Stoffwechsels der Magenwandzellen. Vier Tage nch der SPV kommt es zur Regeneration des Metabolismus. Eine Woche nach der Operation ist die funktionelle Zellregeneration abgeschlossen, der Stoffwechsel aber verlangsamt. Dies hat eine reduzierte Produktion von S`aure und Schutzfaktoren der Magenschleimhaut zur Folge. Experimentelle Läasionen der Magenschleimhaut durch Phenylbutazon bewirken ebenso eine Zerstörung des Stoffwechsels der Magenwandzellen bis zum kompletten Zelluntergang.
    Notes: Summary The phosphate metabolism of the gastric wall after proximal selective vagotomy (PSV) was investigated by means of 31P-NMR spectroscopy. The destruction of metabolism has been found just after PSV resulting in a significant decrease of adenosine diphosphates and adenosine triphosphates. 4 and 7 days after PSV the progress of metabolism regeneration was detected, nevertheless with the retardation of high energy phosphates ischemic degradation. The results indicate not only a hydrochloric acid activity reduction but diminution of gastric mucosa protective factors, too. In experimental gastric ulcers no energy phosphates have been found suggesting a mucosa cells necrobiosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187439
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  • 2
    Electronic Resource
    Electronic Resource
    Gould-Jacobs reaction of 6-amino-2,3-diphenylquinoxaline (1995)
    Springer
    Monatshefte für Chemie 126 (1995), S. 1349-1358 
    Details
    ISSN: 1434-4475
    Keywords: Pyrazinoquinolones ; Quinoxalinoaminoethylenes ; 6-Aminoquinoxalines ; 1H and13C NMR ; Biological activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Katalytische Hydrierung von 2,3-Diphenyl-6-nitrochinoxalin ergibt das entsprechende Amin1, welches bei Reaktion mit den Alkoxymethylenderivaten2a-i zu den Produkten3a-i führt. Thermische Cyclisierung von3b und3f liefert die substituierten Pyrazinochinolone5b und5f. Für die Hydrolyse des Esters5b wurden optimale Bedingungen ermittelt. Die Strukturen aller Produkte wurden aus spektroskopischen Daten hergeleitet (IR, UV,1H- und13C-NMR).
    Notes: Summary Catalytic hydrogenation of 2,3-diphenyl-6-nitroquinoxaline led to the corresponding amine1 which in turn afforded products3a-i on reaction with alkoxymethylene derivatives2a-i. Thermal cyclization of3b and3f yielded substituted pyrazinoquinolones5b and5f, respectively. Optimal conditions for the successful hydrolysis of ester5b were found. The structures of all products were deduced from their IR, UV,1H, and13C NMR spectroscopic data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807064
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  • 3
    Electronic Resource
    Electronic Resource
    1H NMR Ganglioside Ceramide Resonance Region on the Differential Diagnosis of Low and High Malignancy of Brain Gliomas (1997)
    Springer
    Cellular and molecular neurobiology 17 (1997), S. 521-535 
    Details
    ISSN: 1573-6830
    Keywords: brain gliomas ; ceramide ; ganglioside ; malignancy ; 1H NMR spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. The high-resolution 1H NMR (MRS) spectra of human brain tumor homogenates revealed a broad resonance at 5.3–5.4 ppm in glioblastoma multiforme (N = 16) and brain metastases (N = 2). The broad resonance was identified as ceramide, a sphingosine–fatty acid combination portion of ganglioside, indicating an elevated abundance of monounsaturated fatty acids. GLC analysis of gangliosides in the highly malignant glioblastoma multiforme revealed that the elevated monounsaturated fatty acid is oleic acid (C18:1). The resonance at 5.3–5.4 ppm region was not detectable in normal human brain (N = 2), in meningiomas (N = 2), or in low-grade astrocytomas (N = 12). In normal human brain the abundance of monounsaturated fatty acid is minimal. 2. This investigation was made possible because the method of producing homogenate resulted in (i) no loss of lipids during the process and (ii) a well-homogenised sample, with (iii) no loss in chemical integrity. 3. The properties of tumor gangliosides include antigenic specificity and immunosuppresive activity and the ceramide, a sphingosine–fatty acid combination, noticeably influences the ganglioside immunosuppressive activity. 4. The observation of 1H NMR ceramide resonance in high-malignant brain tumors emphasizes the dramatic role of aberrant gangliosides and ceramide precursors on the grade of malignancy and invasiveness. 5. Further insight into the specific nature of the ceramide portion of gangliosides in grading the malignancy of brain tumors should be investigated further.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026362922549
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