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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 70 (1992), S. 611-613 
    ISSN: 1432-1440
    Keywords: Ulcerative colitis ; Cyclosporine ; Inflammatory bowel disease ; Infectious diarrhea ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In recent studies, cyclosporine has been used for the treatment of both ulcerative colitis and Crohn's disease. The results of these studies were variable. We report on a patient who was treated for 6 years with cyclosporine after kidney transplantation. He developed chronic distal colitis with all the features of ulcerative colitis. An infectious etiology of the colitis was carefully excluded. High-dose treatment with methylprednisolone was required to induce remission. This report shows that immunosuppressive therapy with cyclosporine did not prevent the development of ulcerative colitis in this patient.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Bacillary angiomatosis ; Rochalimaea ; Acquired immunodeficiency virus ; Human immunodeficiency virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 52-year old male homosexual patient with acquired immunodeficiency syndrome (AIDS) presented in our clinic with multiple nodular papules (more than 100) spread over the whole body which had developed within 3 months. Bacillary angiomatosis was suspected, which is a bacterial infectious disease recognized recently mainly in patients with AIDS. Histological and immunohistochemical examinations of extirpated skin lesions were in agreement with the diagnosis, and the detection of rod-shaped bacteria in the lesions by Warthin-Starry silver stain confirmed it. The patient was treated with 2 × 100 mg doxycycline per day. The fever disappeared, and the cutaneous lesions showed a slight tendency to improve. However, after 5 days of therapy the patient showed increasing weakness, with muscle and bone pain. The patient died 10 days after the doxycyline therapy had been started. The cutaneous lesions in bacillary angiomatosis may resemble Kaposi's sarcoma and may therefore be misdiagnosed. The disease may be fatal, but timely antibiotic treatment is usually effective; therefore the diagnosis of bacillary angiomatosis is important. Although many cases have been reported from the United States, only one case is known from Europe. Our finding of bacillary angiomatosis in a German AIDS patient supports the concept of a worldwide distribution of this bacterial agent.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Intestinal lymphoma ; Human mucosal lymphocyte antigen 1 ; Intraepithelial T cell ; Small intestine ; Enteropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 64 (1979), S. 243-249 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 58 (1978), S. 487-491 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1262
    Keywords: Key words Pouchitis ; Whole-gut lavage fluid ; Permeability ; Ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pouchitis is the most significant long-term complication in patients with ileoanal pouch anastomosis (IAP) and is especially frequent in patients with ulcerative colitis. There is an urgent need for simple and objective parameters to assess the presence and activity of pouchitis. Whole-gut lavage fluid (WGLF) was collected from 34 patients [8 with pouchitis (PDAI ≥7 points) and 26 without pouchitis (Pouchitis Disease Activity Index, PDAI, 〈7)]. Patients with active ulcerative colitis (n = 8) served as controls. Concentrations of IgG and sCD44 in WGLF were measured by enzyme-linked immunosorbent assays and those of albumin by immunoturbidimetry. Similar to the case in active ulcerative colitis, concentrations of IgG, albumin, and sCD44 in WGLF were significantly increased in acute pouchitis and reached high specificity (IgG 96%, albumin 96%, sCD44 100%) and acceptable sensitivity (75%) for the diagnosis of acute pouchitis. These parameters were also closely correlated with disease activity as determined by PDAI and endoscopic scoring indices. Assay of protein concentrations in WGLF is thus a simple and objective means for grading inflammation of the pouch and may be useful as a quantitative index of disease activity in clinical studies.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 41 (2000), S. 1302-1317 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Gastrointestinale Infektionen ; Ösophagitis ; Diarrhö ; Gastroenteritis ; HIV-Infektion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Infektionen des Gastrointestinaltraktes gehören weltweit zu den häufigsten Todesursachen. Besonders betroffen sind Kinder in der Dritten Welt. Zur Zeit rechnet man weltweit jährlich mit mindestens 800 Mio. infektiösen Durchfallepisoden, von denen 7–12 Mio. direkt oder indirekt zum Tode führen. In den Industrieländern konnten durch verbesserte hygienische Maßnahmen und besonders durch die Trennung zwischen Abwasser und Trinkwasser enteritische Infektionen weitgehend zurückgedrängt werden. In jüngster Zeit kommt es allerdings zu neuen Herausforderungen im Bereich gastrointestinaler Infektionen. Dies liegt einmal daran, dass sowohl bei Immunkompetenten als auch bei Immuninkompetenten in den letzten Jahren neue Erreger beschrieben wurden, zum anderen auch daran, dass durch den stetig wachsenden weltweiten Tourismus immer mehr gastrointestinale Infektionen importiert werden. Eine weitere Problemgruppe bildet die zunehmende Zahl immunsupprimierter Patienten, wie z. B. die HIV-Infizierten, die Chemotherapierten und die vielen Patienten, die wegen anderer Erkrankungen oder nach Organtransplantation immunsuppressiv behandelt werden müssen. Auf Grund der Fülle an verschiedenen Erregern, der Zunahme an neu beschriebenen Pathogenen und der Entwicklung von Resistenzen, ist die Behandlung der gastrointestinalen Infektionen äußerst komplex, schwierig und in den gängigen Lehrbüchern wenig übersichtlich dargestellt. Deshalb soll die folgende Zusammenfassung den momentanen Behandlungsstandard bei den häufigen und auch für die meisten selteneren intestinalen Infektionen wiedergeben.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 4 (1990), S. 154-160 
    ISSN: 1432-2218
    Keywords: Preoperative staging ; Gastrointestinal tumors ; Endosonography ; Esophagus ; Stomach ; Rectum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracavitary application of ultrasound was first performed for diagnostic purposes in 1967; since that time, it has been more and more widely used. As far as the gastrointestinal tract is concerned, endoscopically controlled ultrasonic probes provide visualization of the various layers of the intestinal wall. It is therefore possible to describe lesions of the esophagus, stomach, and the rectum with regard to their nature and depth of infiltration. Furthermore, periesophageal and perigastric organs can be visualized. It has become evident that endosonography is particularly important for pretherapeutic staging of tumors of the esophagus, stomach, and rectum. Here prospective comparative studies confirm the superiority of this new diagnostic procedure when compared to the methods available to date.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 69 (1991), S. 443-445 
    ISSN: 1432-1440
    Keywords: HIV ; AIDS ; Small intestine ; Microsporidiosis ; Enterocytozoon bieneusi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since intestinal microsporidiosis might be of importance in the pathogenesis of gastrointestinal symptoms in patients infected with HIV, we examined duodenal biopsies of HIV-infected patients by electron microscopy. Enterocytozoon bieneusi infection of the small intestine was found in one of 23 patients studied, which gives a 95% confidence interval for the prevalence rate between 0.1 % and 22%. The infected patient was a 24-year-old homosexual male with AIDS who underwent upper endoscopy because of acute epigastric pain, nausea, and vomiting. These symptoms were obviously due to mesenterial Kaposi's sarcoma obstructing the duodenal passage, as was later revealed at autopsy. However, microsporidiosis might have caused the patient's eight-month history of diarrhea and weight loss, since infected cells showed signs of degeneration, and no other pathogens were ever detected in stool or biopsy. Our finding of Enterocytozoon bieneusi infection in a German AIDS patient supports the concept of a worldwide distribution of this parasite; further studies are needed to define its exact prevalence in HIV-infected patients and its pathogenic relevance.
    Type of Medium: Electronic Resource
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