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  • 1980-1984  (4)
  • 1982  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 68 (1982), S. 47-56 
    ISSN: 1432-1424
    Keywords: hydrostatic pressure ; potassium flux ; erythrocyte membrane ; water of hydration ; anion effect ; thermodynamic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effects of hydrostatic pressure and temperature on the three components of K+ uptake in human red cells have been investigated, using ouabain and bumetanide to distinguish between the pump, passive diffusion and cotransport. The pressure sensitivity for passive diffusion has been shown to depend on the counter-ion present. The order of this effect, Cl−〉Br−〉NO 3 − 〉I−, is the same as for the ionic partial modal volumes and the Hofmeister series. We have analyzed our experimental results thermodynamically, and propose a model for the activated transition-state complex of the potassium ion which involves the loss of water molecules from the secondary hydration shell, cosphere II.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 86 (1982), S. 4400-4404 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 72 (1982), S. 143-168 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 30 Patienten mit Antibiotika-assoziierter Colitis (PMC) wurde der Stuhl aufClostridium difficile und sein Cytotoxin untersucht. Bei drei Patienten waren Coloskopie oder Bariumeinlauf zur Absicherung der Diagnose einer PMC erforderlich, da der Befund der Sigmoidoskopie diagnostisch nicht weiterführte. Bei 27 der 30 Patienten waren Erreger und Cytotoxin nachweisbar; bei zwei der restlichen Patienten wurdeStaphylococcus aureus als Ursache für die PMC ausgeschlossen. 19 Patienten mitC. difficile-induzierter PMC wurden oral mit Vancomycin behandelt, 18 davon sprachen auf die Therapie an; doch trat nach Absetzen von Vancomycin bei sieben Patienten ein Colitis-Rezidiv auf. Diese Rezidive sprachen im allgemeinen auf eine nochmalige Vancomycinbehandlung an. Der Nachweis von Schleimhautplaques oder einer Pseudomembran ist der beste Nachweis für eine Beteiligung vonC. difficile. Der kulturelle Nachweis vonC. difficile in den Faeces und der Cytotoxin-Test sind wegen des Vorkommens von asymptomatischen Trägern in ihrem diagnostischen Wert eingeschränkt.
    Notes: Summary Thirty patients with antimicrobial agent-associated pseudomembranous colitis (PMC) were studied for the presence ofClostridium difficile and its cytotoxin in feces. Either colonoscopy or barium enema radiography was required in three patients for the diagnosis of PMC because of nondiagnostic findings at sigmoidoscopy. Both the organism and cytotoxin were detected in 27 of the 30 patients;Staphylococcus aureus was excluded as the cause of PMC in two of the remaining patients. Eighteen of 19 patients withC. difficile-induced PMC who were treated with oral vancomycin had a salutary response; seven patients, however, had a relapse of colitis following the discontinuation of vancomycin. In general, relapses of colitis responded to retreatment with vancomycin. The implication ofC. difficile as a cause of diarrhea is best achieved by the demonstration of colonic mucosal plaques or of a pseudomembrane. The value of fecal culture forC. difficile and cytotoxin assay is limited by the existence of asymptomatic carriers.
    Type of Medium: Electronic Resource
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