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  • 1
    Electronic Resource
    Electronic Resource
    The Recreational Value of Cley Marshes Nature Reserve: An Argument Against Managed Retreat? (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 12 (1998), S. 0 
    Details
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: In the shoreline management plan for the coast of North Norfolk (England), managed retreat has been identified as the most preferable option for the Cley Marshes nature reserve. In general, arguments in favour of managed retreat are (i) opportunities for nature restoration and development, (ii) economic efficiency, and (iii) enhanced resilience to environmental stress and shock. However, with respect to the Cley reserve, recent floods have shown that increased salinity is likely to decrease its natural value, while this study shows that the economic-efficiency criterion is not valid either.This paper discusses the application of contingent valuation and travel-cost methods on data collected by interviews of 160 visitors to the reserve, which has provided estimates of the annual recreational value of the site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1747-6593.1998.tb00186.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pathogenetic mechanisms of recurrent herpes simplex virus infections (1976)
    Springer
    Archives of virology 51 (1976), S. 1-13 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317829
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  • 3
    Electronic Resource
    Electronic Resource
    Isolation of herpes simplex virus clones and drug resistant mutants in microcultures (1975)
    Springer
    Archives of virology 49 (1975), S. 73-80 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Suitable dilutions of herpes simplex virus (HSV) preparations inoculated into microcultures of confluent monolayers of human foreskin or Vero cells, in individual wells of plastic “microplates”, induced viral cytopathic effects that resulted from the infection of the cultures by single virus particles. The clonal nature of the viral progeny in isolated wells was supported by visual control over the development of viral foci and by statistical analysis. The method has the advantage of speed and economy, while it also yields a large primary clonal virus stock. HSV clones resistant to phosphonoacetic acid (PAA) and 5-iodo-2′-deoxyuridine (IUdR) could be readily isolated by the described technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02175598
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless mice (1981)
    Springer
    Archives of virology 68 (1981), S. 73-80 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hairless mice were immunized with herpes simplex virus type 1 (HSV-1) envelope antigen (EAG), EAG in association with polyriboinosinic · polyribocytidylic acid-poly-L-lysine complexed with carboxymethylcellulose (PICLC), and inactivated purified HSV-1 (VAG). After 2 weeks the mice were challenged by a percutaneous HSV-1 infection in the orofacial (OF) or lumbosacral (LS) skin area. Following immunization a consistent cell-mediated immune response was observed in all immunized mice, although the humoral immune response was very low, or not detectable. After challenge, a marked secondary humoral and cell-mediated immune response developed in all immunized mice, and the animals were protected against the development of skin lesions and the fatal outcome of infection. However, the establishment of latent infections in the sensory ganglia was not prevented by the immunization procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314437
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  • 5
    Electronic Resource
    Electronic Resource
    Latent herpes simplex virus in ganglia of mice after primary infection and reinoculation at a distant site (1978)
    Springer
    Archives of virology 57 (1978), S. 161-166 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV)-infected hairless mice with evidence of latent infection in spinal ganglia did not develop latent HSV infections in trigeminal ganglia upon reinfection in the oro-facial area. HSV-infected and PAA-treated mice without evidence of latent HSV infection in spinal ganglia were resistant to reinfection in the lumbar region, but not to that performed in the oro-facial area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315677
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental skin infection with an Acyclovir resistant herpes simplex virus mutant: Response to antiviral treatment and protection against reinfection (1980)
    Springer
    Archives of virology 65 (1980), S. 237-246 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin infections induced in hairless mice with an Acyclovir resistant herpes simplex virus (HSV) mutant were not followed by the death of the animals, and the survivors had no evidence of latent infections in their sensory ganglia. However, mutant virus was detected in the ganglia during the acute phase of the infection. Mice inoculated with the mutant were fully protected against the fatal outcome of the infection when subsequently challenged with the relatively pathogenic parental virus. In addition the frequency of latent infections established after challenge was significantly reduced. Phosphonoacetic acid treatment of the primary mutant-induced infection abolished the protection against reinfection with parental virus. Acyclovir treatment of the primary infection with the mutant virus did not affect the protection against reinfection with parental virus. The results indicate that drug-resistant, latency-negative, HSV mutants are a promising starting point for the development of an attenuated HSV vaccine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314540
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  • 7
    Electronic Resource
    Electronic Resource
    Dissemination of herpes simplex virus in ganglia after footpad inoculation in neurectomized and non-neurectomized mice (1983)
    Springer
    Archives of virology 77 (1983), S. 231-238 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After unilateral footpad inoculation with herpes simplex virus (HSV) the infection spreads initially to the ipsilateral and afterwards to the contralateral spinal ganglia. In about 25 percent of the mice the virus also reaches the trigeminal ganglia. Furthermore, we have shown that only a complete severance of the nervous connections can prevent the colonization of ganglia with HSV after footpad inoculation. Results of previous experiments in which only the sectioning of the sciatic nerve was able to prevent the invasion of ganglia, are difficult to explain. It appears also that HSV travels in the nerve toward the ganglia in a non-infectious form, and that the infectious virus detectable in nerves originates not from the peripheral inoculation site, but from the infectious virus pool which accumulates in spinal ganglia. A limited role of the circulatory system in the colonization of sensory ganglia by HSV cannot be excluded, since in a few cases virus was detected in ganglia after sectioning of both the sciatic and the femoral nerve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309270
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  • 8
    Electronic Resource
    Electronic Resource
    The pathogenesis of acute, latent and recurrent herpes simplex virus infections (1982)
    Springer
    Archives of virology 72 (1982), S. 143-168 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01348961
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