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  • 1985-1989  (4)
  • 1986  (1)
  • 1985  (3)
  • 1
    Electronic Resource
    Electronic Resource
    The potency of heparin-like activity of glycosaminoglycans released by human endothelial cells in culture (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 671-673 
    Details
    ISSN: 1420-9071
    Keywords: Endothelial cells ; glycosaminoglycan ; heparin, smooth muscle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Glycosaminoglycans isolated from culture medium conditioned by human endothelial cells showed heparin-like antithrombin III cofactor activity measured by Xa inhibition. Their activity was relatively weak, 0.1% of the potency of heparin, but was approximately 5-fold more potent than that of glycosaminoglycans derived from vascular smooth muscle cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02007713
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Acetylcholine-induced change in intracellular Cl− activity of the mouse lacrimal acinar cells (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 108-111 
    Details
    ISSN: 1432-2013
    Keywords: Lacrimal gland ; Cl− activity ; Acetylcholine ; Cl− permeability ; Ca2+ ionophore
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using double-barreled Cl−-sensitive microelectrodes, intracellular Cl− activity (A Cl i ) in the mouse lacrimal acinar cells in vitro was determined in both resting and secretory phases. In the resting stateA Cl i was 31 mmol/l which was 1.4 times higher than that predicted for the passive distribution according to the membrane potential (V m) of −41 mV. Addition of acetylcholine (ACh, 1μM) hyperpolarizedV m to −63 mV and decreasedA Cl i to 20 mmol/l which was still twice the equilibrium activity. A-23178 produced similar changes inV m andA Cl i to those induced by ACh. It was concluded that Cl− was actively accumulated in the acinar cells and, in the secretory phase, Cl− efflux was enhanced by the increased driving force and Ca2+-mediated increase in the Cl− permeability across the cell membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584530
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Depletion of membrane phospholipid and mitochondrial dysfunction associated with coronary reperfusion (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 241-250 
    Details
    ISSN: 1435-1803
    Keywords: phospholipase ; phospholipids ; mitochondria ; reperfusion injury ; canine heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of phospholipase (PLase) in the development of heart mitochondrial dysfunction following reperfusion was studied together with the effects of dilazep on the action of PLases and reperfusion injury. In vivo experiment: Seventy six adult mongrel dogs were divided into 3 groups; the control group (n=36), the dilazep 0.5 mg group (n=17) and the dilazep 1 mg group (n=23). Fifteen min after premedication with physiological saline or dilazep (0.5 mg/kg or 1 mg/kg), the left anterior descending coronary artery was occluded for 15 min and then reperfused for 5 min. Each group was further divided into two subgroups depending on the presence or absence of reperfusion arrhythmia. Immediately after 5 min of reperfusion, myocardial mitochondria were prepared from the normal and the reperfused areas. Pretreatment with dilazep induced a dose-dependent decrease in the incidence of reperfusion arrhythmia from 31% of the control to 24% (0.5 mg/kg) and 9% (1 mg/kg). In the arrhythmia cases in each group, functional deterioration of mitochondria from the reperfused area was observed with the increase in free fatty acids and the decrease in phospholipids in the reperfused mitochondria. In vitro experiment: Using L-α-dimyristoyl phosphatidylcholine as a substrate, myristic acid released by PLase A2 or by PLase C with or without pretreatment by dilazep was quantitatively determined. Dilazep inhibited the release of myristic acid by PLase A2 or by PLase C in a concentration-dependent manner. These results suggest that decomposition of mitochondrial membrane phospholipids caused by PLase activation following reperfusion was primarily responsible for the development of mitochondrial dysfunction, and that dilazep showed beneficial effects against reperfusion injury by inhibiting the action of PLases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907900
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Applicability of Friedman plot (1986)
    Springer
    Journal of thermal analysis and calorimetry 31 (1986), S. 547-551 
    Details
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Durch Erweiterung der ursprünglichen Gleichung wird gezeigt, daß die Friedman-Methode zur Bestimmung der Aktivierungsenergie chemischer Reaktionen unter Verwendung sowohl der Konversion als auch der Geschwindigkeit in thermoanalytischen Daten breite Anwendungsmöglichkeiten auf dem Gebiet des Wachstums von Kristallen aus Keimen, der Diffusion und anderer aus nur einem Grundprozeß bestehenden Vorgänge bietet.
    Abstract: Резюме Расширением первона чального уравнения, показано, что метод Фр идмэна для установления энерги и активации химическ их реакций с использованием пара метров превращения и скорос ти в термоаналитичес ких данных широко применимо к пр оцессу роста кристаллов на основе существующих центро в кристаллизации, к про цессу диффузии и друг им процессам, в которых и меет место единствен ный процесс.
    Notes: Abstract By expanding the initial equation, it is shown that the Friedman method for estimating the activation energy of chemical reactions by using both the conversion and the rate in the thermoanalytical data has wide applicability to crystal growth from pre-existing nuclei, diffusion and other processes in which a single unit process is involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01914230
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    Paper (German National Licenses)
    Fulltext
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