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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical studies on human brain tumors using anti-Leu 7 monoclonal antibody in paraffin-embedded specimens (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 75-77 
    Details
    ISSN: 1432-0533
    Keywords: Anti-Leu 7 ; Four-step PAP method ; Oligodendroglioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the four-step peroxidase-antiper-oxidase (PAP) method, the presence of the antigen recognized with anti-Leu 7 monoclonal antibody was investigated in paraffin-embedded human brain tissue and tumors. The antigen was demonstrated in the myelin sheaths, oligodendrocytes, and some choroid plexus cells in normal brain and in oligodendrogliomas, some astrocytomas and choroid plexus papillomas. The technique can be used to identify hormal and neoplastic oligodendrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698299
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical studies on cellular character of microtumors induced by ethylnitrosourea in the rat brain utilizing anti-leu 7 and anti-glial fibrillary acidic protein antibodies (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 167-169 
    Details
    ISSN: 1432-0533
    Keywords: Rat ; ENU ; Brain tumor ; Anti-Leu 7 ; GFAP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the chronologic changes in the cellular morphology of ENU-induced rat brain tumors, microtumors in the early stage were examined ummunohistochemically in comparison with macrotumors in the advanced stage. The tumor cells composing microtumors were negative for glial fibrillary acidic protein (GFAP), a specific marker of astrocylic cells, and Leu 7, a marker of oligodendrocytes, while cells of macrotumors were positive for either GFAP or Leu 7, showing characteristics of mature glial cells. The results suggested that the small round cells in the early devolopmental stage, generally thought to resemble mature oligodendrocytes, are not differentiated oligodendrocytes or astrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688694
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  • 3
    Electronic Resource
    Electronic Resource
    Choroid plexus papilloma and giant cell glioblastoma induced in hamsters with bovine adenovirus type 3 (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 218-222 
    Details
    ISSN: 1432-0533
    Keywords: Choroid plexus papilloma ; Giant cell glioblastoma ; Bovine adenovirus type 3 ; Hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Newborn hamsters were inoculated with 0.02 ml of bovine adenovirus type 3 (BAV 3) having a titer of 104.5TCID50/0.1 ml. Of 82 hamsters observed over 40 days after viral inoculation, 15 developed choroid plexus papilloma after a latency period of 41–228 days and six developed giant cell glioblastoma after a latency period of 66–214 days. Multiple foci of abnormal cell grwoth were also observed in the meninges and choroid plexus. Choroid plexus papilloma developed in the ventricles occupying the ventricular cavity and histologically showed a radiating arrangement of spindle-shaped cells forming perivascular pseudorosettes. Giant cell glioblastoma developed in the cerebral cortex including the meninges. The tumors were reddish in color and soft in consistency. Histologically, the tumor cells were short-spindle, ovar or, pleomorphic cells with a large vesicular nucleus, and were characterized by the appearance of monster cells and hypervascularity. The short spindle-shaped cells were positive for glial fibrillary acid protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688586
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  • 4
    Electronic Resource
    Electronic Resource
    Spinal ganglia and peripheral nerves from a patient with Tay-Sachs disease (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 239-244 
    Details
    ISSN: 1432-0533
    Keywords: Tay-Sachs disease ; Spinal ganglia ; Peripheral nerves ; Gangliosides ; Membranous inclusion bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the spinal ganglia and peripheral nerves from a patient with Tay-Sachs disease, comparing the other nervous tissues morphologically and lipid-biochemically. The spinal ganglia and peripheral nerves showed numerous membranous cytoplasmic inclusion bodies (MCBs), which are characteristic of GM2-ganglioside storage in the neuronal cell bodies of the patient brains. In spinal ganglia, all neurons and satellite cells around the neurons contained membrane-bound lipid materials. In peripheral nerves, Schwann cells and myelinated axons except for enlarged axons were devoid of MCBs. Major ganglioside stored in both spinal ganglia and peripheral nerve was also GM2-ganglioside. The contents of ganglioside in the spinal ganglia and peripheral nerves were 50 and 10 times more than those from normal tissues, respectively. The spinal cord contained a slightly higher amount of gangliosides than the normal control. The cerebral white matter fotally demyelinated in this patient accumulated a much higher amount of gangliosides than the cerebral gray matter. The retinal tissue showed GM2-ganglioside as the major one also.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688589
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of orally administered glandular kallikrein on urinary kallikrein and prostaglandin excretion, plasma immunoreactive prostanoids and platelet aggregation in essential hypertension (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 332-336 
    Details
    ISSN: 1432-1440
    Keywords: Glandular kallikrein ; Immunoreactive 6-keto PGF1α and thromboxane B2 ; Platelet aggregation ; Essential hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of orally administered glandular kallikrein on urinary kallikrein, aldosterone and prostaglandin E (PGE) excretion, plasma renin activity (PRA), immunoreactive 6-keto PGF1α and thromboxane B2 concentrations and platelet aggregation were studied in 12 patients with essential hypertension (EH). After a 2-week control period, each patient was given orally 450 KU/day of hog glandular kallikrein for 8 weeks. Urinary kallikrein, aldosterone and PGE excretion, and plasma 6-keto PGF1α and thromboxane B2 concentrations were measured by radio-immunoassay. Platelet aggregation was measured by the addition of ADP, collagen or ristocetin with an aggregometer. Urinary kallikrein excretion and plasma 6-keto PGF1α concentration were significantly decreased in patients with EH. There were no significant differences in PRA, urinary aldosterone excretion and plasma thromboxane B2 concentrations between control subjects and patients with EH. There was a significant decrease in blood pressure in patients with EH coinciding with significant increases of urinary kallikrein and PGE excretion and plasma immunoreactive 6-keto PGF1α concentration after administration of glandular kallikrein. There was also a significant inhibition of platelet aggregation induced by collagen in these patients. Thus, a suppression of the kallikrein-kinin-prostaglandin system in patients with EH was found, and a decrease in blood pressure with an increment of urinary kallikrein, PGE excretion, plasma immunoreactive 6-keto PGF1α and inhibition of platelet aggregation in vivo by the administration of glandular kallikrein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731977
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of trifluoperazine and chlorpromazine on calciumrepleted injury in isolated ventricle strips (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 556-563 
    Details
    ISSN: 1435-1803
    Keywords: trifluoperazine ; chlorpromazine ; calmodulin inhibitors ; isolated right ventricle strips ; calcium paradox
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We observed changes in the performance of isolated right ventricle strips taken from rats when calcium was repleted following various periods of calcium depletion in order to study certain phenomena, such as the calcium paradox, in this preparation. Furthermore, to assess the possible role of calmodulin in this myocardial damage, the effects of known calmodulin inhibitors such as trifluoperazine and chlorpromazine on the contractility and resting tension were studied by means of the calcium repletion after a calcium-depleted period of 12 min. The temperature was kept at 37°C, and the muscle strips were stimulated electrically at a rate of 0.25 Hz. When there was a calcium-depleted period of longer than 8 min, a marked increase in resting tension was observed and reached maximum at 2 to 4 min. The recovery of peak developed tension and peak positive or negative dT/dt worsened as the duration of the calcium depletion was longer. These findings indicate the massive intracellular calcium influx by the calcium reintroduction and the myocardial damage induced by the calcium overload as observed in isolated whole hearts. Treatment with trifluoperazine (1–5 μM) and chlorpromazine (1–5 μM) did not inhibit a rise in resting tension significantly after the calcium repletion, except for 5 μM of both drugs at 6 min. Trifluoperazine significantly improved the recovery of the contractility (developed tension and dT/dt), whereas the protective effect of chlorpromazine was not obtained. These results suggest that the depression of calmodulin activity is beneficial in the prevention of myocardial damage produced by calcium repletion, although there is a difference in the effect of the calmodulin inhibitors, trifluoperazine and chlorpromazine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907919
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  • 7
    Electronic Resource
    Electronic Resource
    Depletion of membrane phospholipid and mitochondrial dysfunction associated with coronary reperfusion (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 241-250 
    Details
    ISSN: 1435-1803
    Keywords: phospholipase ; phospholipids ; mitochondria ; reperfusion injury ; canine heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of phospholipase (PLase) in the development of heart mitochondrial dysfunction following reperfusion was studied together with the effects of dilazep on the action of PLases and reperfusion injury. In vivo experiment: Seventy six adult mongrel dogs were divided into 3 groups; the control group (n=36), the dilazep 0.5 mg group (n=17) and the dilazep 1 mg group (n=23). Fifteen min after premedication with physiological saline or dilazep (0.5 mg/kg or 1 mg/kg), the left anterior descending coronary artery was occluded for 15 min and then reperfused for 5 min. Each group was further divided into two subgroups depending on the presence or absence of reperfusion arrhythmia. Immediately after 5 min of reperfusion, myocardial mitochondria were prepared from the normal and the reperfused areas. Pretreatment with dilazep induced a dose-dependent decrease in the incidence of reperfusion arrhythmia from 31% of the control to 24% (0.5 mg/kg) and 9% (1 mg/kg). In the arrhythmia cases in each group, functional deterioration of mitochondria from the reperfused area was observed with the increase in free fatty acids and the decrease in phospholipids in the reperfused mitochondria. In vitro experiment: Using L-α-dimyristoyl phosphatidylcholine as a substrate, myristic acid released by PLase A2 or by PLase C with or without pretreatment by dilazep was quantitatively determined. Dilazep inhibited the release of myristic acid by PLase A2 or by PLase C in a concentration-dependent manner. These results suggest that decomposition of mitochondrial membrane phospholipids caused by PLase activation following reperfusion was primarily responsible for the development of mitochondrial dysfunction, and that dilazep showed beneficial effects against reperfusion injury by inhibiting the action of PLases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907900
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