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  • 1
    Electronic Resource
    Electronic Resource
    Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 575-580 
    Details
    ISSN: 1432-0533
    Keywords: Senile dementia of Alzheimer's type ; Alzheimer's disease ; Pick's disease ; Laminar neuronal loss ; Limbic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven cases of senile dementia of Alzheimer type (SDAT) with unusual clinico-pathological findings are reported. The patients showed neuronal loss in laminar pattern, with gliosis exclusively confined to the CA1 of the hippocampus, the area of the hippocampal gyrus (entorhinal cortex) and medial occipitotemporal cortex. This change was more pronounced in the oral region. The subcortical white matter showed more pronounced fibrillary gliosis than loss of myelin. Both Alzheimer's neurofibrillary tangles and senile plaques were less marked than those usually seen in SDAT. The mental disturbance started after the age of 65 in all patients. The main clinical feature was marked character change in addition to disturbance of cognitive function. Cranial computed tomography showed marked dilatation of the oral portion of the inferior horn of the lateral ventricle in the early stage. It was apparent that although the cases in this group could be incorporated within in the spectrum of SDAT, they could also be considered to represent a variant of SDAT. This group could contribute to an understanding of the clinico-pathological spectrum of SDAT as well as indicating ways of managing such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307623
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Curly fibers are tau-positive strands in the pre- and post-synaptic neurites, consisting of paired helical filaments: observations by the freeze-etch and replica method (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 111-115 
    Details
    ISSN: 1432-0533
    Keywords: Curly fibers ; Anti-tau antibody ; Immunoelectron microscopy ; Rapid-freeze and deep-etch method ; Neuritic paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the neurites had similar dimensions to those of Alzheimer's neurofibrillary tangles in the nerve cell somata, having the width of 28 to 36 nm. The two component filaments, 14 to 18 nm in width, were twisted left-handedly with about 70- to 90-nm intervals. There were also cross-bridging fibrils of about 6 nm in diameter connecting the neighboring PHF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334498
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Specific activity of99mTcO4 − eluates from clinical99Mo/99mTc generators (1990)
    Springer
    Journal of radioanalytical and nuclear chemistry 146 (1990), S. 359-365 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Carrier-free99mTcO4 − eluated from clinical99Mo/99mTc generators was examined to determine its specific activity. The observed specific activity was found to be always lower than the calculated value based on the99Mo−99mTc−99Tc decay scheme data. These results could be explained in terms of existence of excess Tc loaded onto generator column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02164238
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical expression of glutathione S-transferase placental type (GST-π), a detoxifying enzyme, in normal arachnoid villi and meningiomas (1990)
    Springer
    Virchows Archiv 417 (1990), S. 493-496 
    Details
    ISSN: 1432-2307
    Keywords: Arachnoid villi ; Meningioma ; Glutathione S-transferase placental type ; Cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human normal dura mater containing arachnoid villi were examined for their expression of glutathione S-transferase placental type (GST-π), a detoxifying enzyme, using an immunohistochemical method. All of the arachnoid villi and arachnoid cells in five normal cases were found to have expression of GST-π, although no positive reaction for the enzyme was present in other tissues of the dura mater. The results show a possible role for arachnoid tissues in protecting human brain from hazardous xenobiotics in the cerebrospinal fluid. Twenty-six meningiomas were also examined for expression of the enzyme. Tissues of meningotheliomatous meningiomas were always positive for expression of the enzyme. Transitional meningiomas also showed the expression in their meningotheliomatous components. No staining reaction of GST-π was recognized in fibroblastic meningiomas except for two cases with a tendency to meningotheliomatous differentiation. The findings suggest a functional similarity between the arachnoid tissues and meningotheliomatous components of meningiomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01625729
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  • 5
    Electronic Resource
    Electronic Resource
    Biological activity of enantiomerically pure forms of insect juvenile hormone I and III inBombyx mori (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 220-221 
    Details
    ISSN: 1420-9071
    Keywords: Juvenile hormone ; enantiomer ; biological activity ; Bombyx mori ; allatectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Biological activity of enantiomerically pure juvenile hormones was assayed by topical application on allatectomizedBombyx fourth instar larvae. JHs tested were (10R)-JH I [methyl (2E,6E,10R,11S)-10,11-epoxy-3,11-dimethyl-7-ethyl-2,6-tridecadienoate], (10S)-JH I [methyl (2E, 6E, 10S, 11R)-10,11-epoxy-3,11-dimethyl-7-ethyl-2,6-tridecadienoate], (10R)-JH III [methyl (2E,6E,10R)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate] and (10S)-JH III [methyl (2E,6E,10S)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadienoate]. Among these compounds, natural (10R)-JH I was most active and the dose needed to induce 50% larval molting was 0.04 μg/larva; it was approximately 12,000 times more active than unnatural (10S)-JH I. Though natural (10R)-JH III showed slight biological activity, it was only one three-thousandth of that of (10R)-JH I. Unnatural (10S)-JH III exhibited no biological activity at the levels assayed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02027321
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    Paper (German National Licenses)
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