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  • 1
    Electronic Resource
    Electronic Resource
    Functional respiratory chain studies in mitochondrial cytopathies. Support for mitochondrial DNA heteroplasmy in myoclonus epilepsy and ragged red fibers (MERRF) syndrome (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 318-323 
    Details
    ISSN: 1432-0533
    Keywords: Mitochondrial disease ; Myoclonus epilepsy and ragged red fibers (MERRF) syndrome ; Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome ; Polarographic studies ; Immunoblot studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mitochondrial respiratory chain function was investigated with polarographic and enzymatic studies, and correlated with immunoblot studies using a battery of probes against respiratory chain holocomplexes in a series of patients with myoclonus epilepsy and ragged red fibers (MERRF) syndrome. State III respiration rates in intact skeletal muscle mitochondria were normal in two cases, suggested site I deficiency in one case and a midrespiratory defect in another. Immunological studies of complex I showed reduced levels of several subunits with the apparent absence of two bands (which at 45 and 42 kDa, coincide with the predicted electrophoretic mobility of the ND5 gene product) in one case. Complex I, III and IV composition was normal in the other three cases indicating no major disruption of complex assembly. A differing severity of skeletal muscle respiratory chain impairment in a group of unrelated patients with severe cerebral clinical involvement is best explained by uneven tissue distribution between brain and muscle of a heteroplasmic mtDNA mutation. The relationship between MERRF and mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) encephalopathies is reappraised by extension of this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305874
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  • 2
    Electronic Resource
    Electronic Resource
    Cardiac anaesthesia in a patient with myotonic dystrophy (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 46 (1991), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a patient with myotonic dystrophy who required open-heart surgery for an atrial septal defect. He also had a sick sinus syndrome and an abnormal myocardium on histological examination. Anaesthesia using fentanyl, droperidol, nitrous oxide and a low concentration of enflurane was uneventful. Atelectasis of the left lung developed on the first postoperative day after removal of the tracheal tube. This was successfully treated by fibreoptic bronchoscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1991.tb11684.x
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  • 3
    Electronic Resource
    Electronic Resource
    Instabilities associated with a negative rf resistance in current-carrying ion sheaths (1991)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 228-235 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Coherent instabilities on the order of the ion plasma frequency are generated by applying a dc voltage between a meshed grid and a disk target in an unmagnetized plasma. The instability occurs in the ion-rich current-carrying sheath on the negatively charged grid when some ions are reflected from the grid to the sheath edge by the potential difference between two plasmas divided by the grid. The exciting mechanism of the instability has been identified as a negative rf resistance associated with the ion inertia in the ion-rich sheath, coupled to an ion resonance caused by a positive feedback due to the reflection of ions in the sheath region. The frequency of the instability, which is proportional to the plasma density, is basically determined by the ion transit time through the sheath, and thus, is proportional to the product of inverse sheath thickness and average ion velocity related to the applied voltage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859940
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular beam epitaxial growth and characterization of CoAl on AlAs/GaAs (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 3115-3117 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We study molecular beam epitaxial growth and structural properties of intermetallic compound CoAl on AlAs/GaAs III-V semiconductors. CoAl has a CsCl structure whose lattice constant is nearly half the lattice constant of GaAs and AlAs, hence, it is a good candidate for the constituent material in epitaxial metal/semiconductor heterostructures. We investigate the dependence of crystallinity of Co1−xAlx epitaxial layers on Al composition x and on growth temperature Ts, by in situ reflection high-energy electron diffraction and ex situ x-ray measurements. It is found that the single-crystalline CoAl with high quality can be obtained at x=0.5 and Ts=350 °C. Under appropriate growth procedures and conditions, the epitaxial growth orientation is (001)[110]CoAl on (001)[110]AlAs/GaAs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.105756
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  • 5
    Electronic Resource
    Electronic Resource
    Linear cutaneous neurilemmomas on the forehead (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 16 (1991), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 35-year-old woman had had pruritic linearly arranged papules on the right side of her forehead for 17 years. A biopsy specimen from one of the papules showed the histopathological appearance of an intradermal plexiform neurilemmoma. No other features of systemic neurofibromatosis or neurilemmomatosis were detected. Neurilemmoma usually occurs as a solitary lesion in the subcutis and there are only few reports of such localized multiple intradermal neurilemmomas associated with neither neurofibromatosis nor neurilemmomatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1991.tb00367.x
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  • 6
    Electronic Resource
    Electronic Resource
    Immunohistopathology of variations of human olfactory mucosa (1991)
    Springer
    European archives of oto-rhino-laryngology and head & neck 248 (1991), S. 370-375 
    Details
    ISSN: 1434-4726
    Keywords: Human olfactory mucosa ; Fetus ; Adult ; Degeneration ; Immunohistopathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The characteristics of the human olfactory mucosa were studied immunohistologically. Regular, tonal distribution of the supporting cells, multilayered olfactory receptor cells and basal cells was commonly found in the olfactory mucosa of the human fetus. In contrast, most of the olfactory mucosa in the adult varied to some extent. In the relatively thick, slightly degenerated olfactory mucosa, olfactory marker protein positive receptor cells were arranged irregularly. The most common evidence for variation was the decrease or disappearance of the olfactory receptor cells. Serous-type lactorferrin-containing glandular acini were characteristically found beneath degenerated epithelium. Islands of respiratory epithelium were also seen. The ductules of the Bowman's glands were distended and the openings of these ductules were wide. There was invagination or epithelial cell processes into the glandular lumina. These findings suggest that the epithelial cells of Bowman's glands play an important role in the regeneration of the human olfactory mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169031
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  • 7
    Electronic Resource
    Electronic Resource
    Neutrophil function in hyperosmotic NaCl is preserved by phosphoenol pyruvate (1991)
    Springer
    Urological research 19 (1991), S. 223-227 
    Details
    ISSN: 1434-0879
    Keywords: Hyperosmolarity ; NaCl ; Neutrophil ; Phosphoenol pyruvic acid ; ATP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hyperosmolority in the urinary tract inhibits the host defense against bacterial infection. NaCl contributes most to osmolority in the renal medulla and urine. Therefore, we studied the effect of hyperosmolar NaCl on neutrophil function. When osmolarity was increased by NaCl, polymorphonuclear leukocytes (PMNL) became defective in phagocytosis, intracellular killing of bacteria, chemotactic activity, and superoxide production. This coincided with a decrease in the intracellular adenosine triphosphate (ATP) content of PMNL. Both the inhibition of superoxide production and the reduction in ATP content did not occur at 4°C. By increasing ATP content, phosphoenol pyruvic acid (PEP) protected against the decrease in superoxide production. These results suggest that leukocyte function is inhibited by high concentrations of NaCl due to the activation of the Na+−K+ pump. PEP, an ATP precursor, can protect PMNL against osmotic stress by raising the intracellular concentration of ATP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305299
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  • 8
    Electronic Resource
    Electronic Resource
    Chlamydia trachomatis antigen can be detected in the urine sample of men with non-gonococcal urethritis (1991)
    Springer
    Urological research 19 (1991), S. 235-236 
    Details
    ISSN: 1434-0879
    Keywords: Chlamydia trachomatis ; First portion of voided urine ; Non-gonococcal urethritis ; Enzymeamplified immunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We tested the first portion of voided urine (FVU) and urethral swab from 80 patients with nongonococcal urethritis (NGU) using a novel enzymeamplified immunoassay (IDEIA) for the detection of Chlamydia trachomatis antigen. Urine specimens were positive in all patients with positive urethral swabs (positive coincidence ratio, 100%) and in 6 of 54 patients with negative swabs (negative coincidence ratio, 88.9%). Our data suggest that FVU is suitable for the detection of Chlamydia trachomatis antigen using the IDEIA test in patients with NGU.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305301
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  • 9
    Electronic Resource
    Electronic Resource
    Role of superoxide in renal scarring following infection by mannose-sensitive piliated bacteria (1991)
    Springer
    Urological research 19 (1991), S. 229-233 
    Details
    ISSN: 1434-0879
    Keywords: Pyelonephritis ; Renal scarring ; Pathogenesis ; Serratia marcescens ; Piliation ; Superoxide dismutase ; Leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of superoxide in scar formation following renal infection caused by mannose-sensitive (MS) piliated strains of bacteria was studied in the experimental pyelonephritis model using female Sprague-Dawley rats. The MS piliated strain stimulated renal scarring to a significantly greater extent than either the non-piliated or MR-piliated strain. Modulation of leukocytes by administering cyclophosphamide to induce neutropenia and colchicine to inhibit leukocyte migration was effective in preventing renal scarring. Treatment with superoxide dismutase during the early stage of infection was also effective in preventing scar formation. Finally, the production of superoxide by rat leukocytes was significantly larger following stimulation by MS piliated than either the nonpiliated or MR piliated strains. These observations suggest that superoxide released from leukocytes plays a critical role in the development of renal scarring following a bacterial infection, especially by MS piliated strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305300
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  • 10
    Electronic Resource
    Electronic Resource
    Significance of urinary endotoxin concentration in patients with urinary tract infection (1991)
    Springer
    Urological research 19 (1991), S. 293-295 
    Details
    ISSN: 1434-0879
    Keywords: Endotoxin ; Urinary tract infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endotoxin is a component of the outer membrane of gram-negative rods (GNR). Since GNR are responsible for the majority of urinary tract infection (UTI), we measured the concentration of endotoxin in urine using chromogenic endotoxin-specific assay and examined its diagnostic utility in patients with suspected UTI. In all 18 urine samples with an endotoxin concentration exceeding 350 pg/ml and 2 samples with 10–350 pg/ml of endotoxin concentration, GNR were detected at a count of 104 cfu/ml. Negative for endotoxin were 3 samples of culture positive for grampositive cocci (GPC), 2 samples containing various bacterial contaminants and all 37 samples with no growth on culture. Two urine samples collected 5 h after antibiotic dosage showed negative culture for GNR but a significant concentration of endotoxin. In an in vitro experiment, a residual concentration of antibiotic in urine inhibited bacterial growth, leading to a falsenegative culture. These results suggest that chromogenic endotoxin assay is a reliable method for diagnosing UTI caused by GNR and detecting false-negative culture of GNR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299061
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