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  • 1
    Electronic Resource
    Electronic Resource
    Magneto-optical spectra of epitaxial ferromagnetic MnAs films grown on Si and GaAs substrates (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 6791-6793 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have studied magnetic circular dichroism (MCD) spectra of ferromagnetic MnAs epitaxial thin films of (1¯101), (1¯100), and (0001) crystallographic growth orientations. The films were grown on Si(001), Si(111), GaAs(001), and GaAs(111)B substrates by molecular-beam epitaxy. We have found strong crystal orientation dependence of MCD spectra of MnAs films in terms of characteristic features and absolute intensity of MCD signals. We have also measured temperature dependence of MCD spectra on a (0001) MnAs film. Features at low temperatures are found to be different from those at room temperature. Our experimental results are compared with the ionic model for the electronic structure of NiAs-type MnAs and with magneto-optical Kerr ellipticity spectra recently calculated using an all electron full potential linear muffin-tin orbital method. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372843
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  • 2
    Electronic Resource
    Electronic Resource
    Autoantibodies in anti-p200 pemphigoid stain skin lacking laminin 5 and type VII collagen (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report the case of a patient with a widespread bullous skin disease and linear deposits of IgG and C3 at the dermal–epidermal junction using direct immunofluorescence microscopy. Indirect immunofluorescence analysis demonstrated circulating IgG autoantibodies that stained, like autoantibodies to laminin 5 and type VII collagen, the dermal side of 1 mol L−1 NaCl-split human skin. By immunoblotting dermal extracts, the patient’s serum, like serum samples from two control patients, reacted with a 200-kDa protein. Using immunoelectron microscopy, the serum labelled a component of the lower lamina lucida, but not the lamina densa/sublamina densa region, distinguishing this from the type VII collagen localization pattern. By immunofluorescence microscopy on skin sections from patients lacking either laminin 5 (Herlitz’s epidermolysis bullosa) or type VII collagen (recessive dystrophic epidermolysis bullosa of Hallopeau–Siemens), the patient’s serum retained reactivity with these test substrates. The patient’s disease responded rapidly to the use of topical corticosteroids and lesions healed without scarring or milia formation. Our results provide strong evidence for the hypothesis that the 200 kDa autoantigen is different from laminin 5 and type VII collagen. For this new disease, we propose the designation ‘anti-p200 pemphigoid’.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03841.x
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  • 3
    Electronic Resource
    Electronic Resource
    Dissociation of intra- and extracellular domainsof desmosomal cadherins and E-cadherin inHailey–Hailey disease and Darier’s disease (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to clarify the pathomechanism of acantholysis in Hailey–Hailey disease (HHD) and Darier’s disease (DD), the distribution of desmosomal and adherens junction-associated proteins was studied in the skin of patients with HHD (n = 4) and DD (n = 3). Domain-specific antibodies were used to determine the cellular localization of the desmosomal transmembrane glycoproteins (desmogleins 1 and 3 and desmocollin), desmosomal plaque proteins (desmoplakin, plakophilin and plakoglobin) and adherens junction-associated proteins (E-cadherin, α-catenin, β-catenin and actin). A significant difference in staining patterns between intra- and extracellular domains of desmosomal cadherins and E-cadherin was demonstrated in acantholytic cells in both HHD and DD, but not in those in pemphigus vulgaris and pemphigus foliaceus samples used as controls. In acantholytic cells in HHD and DD, antibodies against attachment plaque proteins and intracellular epitopes of desmosomal cadherins exhibited diffuse cytoplasmic staining, whereas markedly reduced staining was observed with antibodies against extracellular epitopes of the desmogleins. Similarly, membrane staining of an intracellular epitope of E-cadherin was preserved, while immunoreactivity of an extracellular epitope of E-cadherin was destroyed. While the DD gene has been identified as ATP2A2, the gene for HHD has not been clarified. The dissociation of intra- and extracellular domains of desmosomal cadherin and E-cadherin is characteristic of the acantholytic cells in HHD and DD, and not of pemphigus. This common phenomenon in HHD and DD might be closely related to the pathophysiological mechanisms in both conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03415.x
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of transglutaminase activity in developing human epidermis (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Epidermal transglutaminase (TGase) is known to catalyse cross-linking of several precursor proteins in the formation of cornified cell envelope at the terminal differentiation of keratinocytes. Expression of TGase activity was studied using an in situ TGase activity assay in human fetal skin samples of 49–163 days estimated gestational age (EGA). In the early two-layered epidermis (49–56 days EGA), in situ TGase activity was not observed in the periderm cells or the basal cells. In the late two-layered epidermis (57–65 days EGA), in situ TGase activity became weakly positive in the periderm cells, but not in the basal cells. In the three-layered (66–95 days EGA) and in four- or more layered (96–135 days EGA) stratified epidermis, in situ TGase activity was still restricted only to the periderm cells. After keratinization occurred in the interfollicular epidermis (163 days EGA), in situ TGase activity was expressed in the granular and cornified layers. This unique localization of TGase activity further support the hypothesis that periderm cells form cornified cell envelope during their regression process in human fetal skin development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03288.x
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  • 5
    Electronic Resource
    Electronic Resource
    Marked swollen erythema of the face together with sicca syndrome as a sign for chronic active Epstein–Barr virus infection (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03936.x
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  • 6
    Electronic Resource
    Electronic Resource
    A case of generalized hair follicle hamartoma associated with diffuse sclerosis of the face (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03864.x
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  • 7
    Electronic Resource
    Electronic Resource
    Glycine substitution mutations by different amino acids in the same codon of COL7A1 lead to heterogeneous clinical phenotypes of dominant dystrophic epidermolysis bullosa (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 477-481 
    Details
    ISSN: 1432-069X
    Keywords: Key words Type VII collagen ; Pruriginosa ; Anchoring fibril ; Basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dystrophic epidermolysis bullosa (DEB), caused by mutations in the gene encoding type VII collagen (COL7A1), is known to show heterogeneous clinical phenotypes. Certain correlations between the nature or position of COL7A1 mutations and the resultant DEB phenotypes have been suggested, although such relationships may be more complex than initially thought. The purpose of the present study was to clarify the molecular basis of two different subtypes of dominant DEB (DDEB), EB pruriginosa and classical type. Interestingly, we found that both cases were caused by a missense glycine substitution mutation by different amino acids in the same codon of COL7A1 (G2028R and G2028A). These results further support the notion that different glycine substitution mutations in the same codon can lead to heterogeneous clinical phenotypes of DDEB, EB pruriginosa and classical type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000162
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  • 8
    Electronic Resource
    Electronic Resource
    LAMB3 gene transfection into SV40-transformed keratinocytes from patient with Herlitz junctional epidermolysis bullosa (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 195-197 
    Details
    ISSN: 1432-069X
    Keywords: Key words Laminin 5 ; Basement membrane ; Blistering disorder ; Gene therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050477
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  • 9
    Electronic Resource
    Electronic Resource
    Diffusion-weighted MRI and selection of patients for fibrinolytic therapy of acute cerebral ischaemia (2000)
    Springer
    Neuroradiology 42 (2000), S. 379-383 
    Details
    ISSN: 1432-1920
    Keywords: Key words Ischaemia, cerebral acute ; Fibrinolysis, intra-arterial ; Magnetic resonance imaging, diffusion-weighted
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment of patients with acute cerebral ischaemic events remains controversial. We investigated the reversibility of high signal intensity on diffusion-weighted (DW) MRI after acute local intra-arterial fibrinolysis (LIF) and the feasibility of DW MRI for selecting patients for acute LIF. Nine patients with acute middle cerebral artery embolic occlusion underwent single-photon emission computed tomography (SPECT) and DW MRI followed by acute LIF using tissue plasminogen activator. Recanalisation was observed in all patients, and eight improved clinically. The area of high signal intensity on pretreatment DW MRI was smaller than the low-uptake area on SPECT in all patients, and went on to infarction, as detected by MRI or CT 3 days after onset in all patients. It appears to correlate, at least clinically, with irreversible brain damage. Therefore, acute LIF should not be performed in patients with areas of high signal intensity in the cortex responsible for the symptoms. SPECT remains important, because areas normal on DW MRI with low uptake on SPECT often contribute to functional prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050904
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