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  • 1
    Electronic Resource
    Electronic Resource
    Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 654-662 
    Details
    ISSN: 1432-0533
    Keywords: Key words Aciculin ; Dystrophin ; Binding site ; Normal and dystrophic muscles ; Ultrastructural ¶localization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aciculin is a novel adherens junction antigen extracted from human uterine smooth muscle that is reported to associate biochemically with dystrophin. We attempted to determine (i) the immunostainability of anti-aciculin antibody for the 6 histochemically normal human muscles and seven muscles from boys with Duchenne muscular dystrophy(DMD) and 11 disease control muscles, (ii) the ultrastructural localization of aciculin in normal skeletal myofibers, (iii) aciculin’s spacial relationship with dystrophin and β-spectrin, and (iv) if the aciculin is ultrastructurally colocalized with dystrophin, the distance from the aciculin epitope to the epitope of the dystrophin N- or C-terminal domain. For this, rabbit anti-aciculin antibody was generated against the synthetic peptide of aciculin fragment D [4]. Immunohistochemical staining showed that the immunostainability of DMD muscles for anti-aciculin antibody was markedly decreased as compared with normal and disease control muscles. Single and double immunogold labeling electron microscopy of 6 histochemically normal human quadriceps femoris muscles revealed that aciculin was present along the inner surface of muscle plasma membrane and that aciculin formed doublets more frequently with dystrophin (23.5 ± 1.8%; group mean ± SE) than with β-spectrin (12.8 ± 1.1%; P 〈 0.01 two tailed t test). Rabbit anti-aciculin antibody frequently formed doublets with monoclonal antibodies against the N- or C-terminal domain of dystrophin at the muscle cell surface. These results suggest that aciculin is associated with dystrophin and may interact with both the N- and C-terminal domains of dystrophin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051176
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  • 2
    Electronic Resource
    Electronic Resource
    Development of new position sensitive electron multiplication device fabricated by LIGA process (2000)
    Springer
    Microsystem technologies 6 (2000), S. 90-93 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050004
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  • 3
    Electronic Resource
    Electronic Resource
    Room-temperature operation of a memory-effect AlGaAs/GaAs heterojunction field-effect transistor with self-assembled InAs nanodots (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 1464-1466 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This letter describes the memory effect of an AlGaAs/GaAs heterojunction field-effect transistor that contains InAs nanodots in the barrier layer. The device experiences a shift of threshold gate voltage, as a function of the amount of the electrons trapped in the nanodots. These trapped electrons can be injected by applying a positive gate voltage and be erased by a visible light illumination at negative gate bias. Although the shift of the threshold gate voltage volatilizes with the time after the memory programing operation, a considerable part of the shift is retained even after 100 h at room temperature. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126065
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  • 4
    Electronic Resource
    Electronic Resource
    Hematite in pyrophyllite ore deposits, Shobara district, southwestern Japan (2000)
    Springer
    Mineralogy and petrology 70 (2000), S. 15-23 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Hämatit aus Pyrophyllitlagerstätten des Shobara Distriktes, SW Japan Hämatit ist ein typisches Mineral in Liesegang-Gesteinen aus Pyrophyllitlagerstätten des Shobara Distriktes, südwestliches Japan. Dieses Mineral koexistiert mit feinkörnigem Pyrophyllit und Quarz, wobei die Hämatitkristalle charakteristischerweise nadel- bis faserförmig ausgebildet sind. Sie sind nur einige Mikrometer lang und sind im Reflexionsmikroskop daher nur bei starker Vergrößerung in Ölimmersion zu beobachten. Diese feinen Kristalle bilden ringförmige Aggregate mit mehreren Zehner-μm Durchmessern aus. Die Kristalle sind sehr oft radialstrahlig in diesen Ringen angeordnet. Mikrosondenuntersuchungen zeigen, dass die Hämatitkristalle fast reines Eisenoxid mit weniger als 0.9 Gew.% Ti sind. XRD Studien belegen, dass Hämatit das einzige Eisenmineral in den Liesegang-Gesteinen ist; d.h. es gibt keine Hinweise auf Fe-Hydroxide. Dies wird durch die Untersuchung des Wassergehaltes und IR Spektroskopie bestätigt.
    Notes: Summary Hematite is a characteristic mineral of Liesegang rock in the pyrophyllite ore deposits, Shobara district, southwestern Japan. The mineral intimately coexists with fine-grained pyrophyllite and quartz. The hematite crystals are characteristically needle-shaped to fibrous, and several microns in length, and can only be observed by high-magnification reflected light microscopy with oil immersion lens. They occur as ring-shaped aggregates several tens of microns in diameter. Moreover, the crystals are often arranged radially within the rings. Microprobe analyses reveal that hematite crystals are almost pure iron oxide, with less than 0.9 wt.% Ti. X-ray powder diffraction patterns and reflection intensities indicate that hematite is the only iron mineral in the Liesegang rock, i.e., no hydrous iron oxides are present. This observation was also confirmed by examinations of water content and infrared spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007100070010
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of effectiveness of chemotherapy in patients with gastric cancer after curative resection (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 372-379 
    Details
    ISSN: 1437-7772
    Keywords: Key words p53 ; Gastric cancer ; Adjuvant chemotherapy ; Randomized study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. A prospective randomized study involving gastric cancer patients was undertaken to evaluate combined adjuvant chemotherapy and the prognostic value of biologic markers. Methods. One hundred and eighty-five patients under 75 years of age who underwent a curable resection of pathologic stage II or III gastric cancer were randomly assigned to receive adjuvant chemotherapy containing either: mitomycin C (MMC) plus oral 5-fluorouracil (FU) (MF), epirubicin plus oral FU (EF), or oral FU (F). Tumor tissue collected at surgery was immunohistochemically analyzed for p53 and proliferating cell nuclear antigen, and DNA ploidy was determined. Results. All prognostic factors were equally distributed in each arm. There was no significant difference among the groups in the 5-year overall survival. When the relationship between the biologic markers and prognosis was analyzed, the overall survival of all patients and stage III patients was poorer in those with p53 positivity, but the difference did not achieve significance. For patients with positive nodes, irrespective of the treatment regimen, p53-positivity was significantly associated with poorer prognosis (P = 0.05). In stage III patients, the survival of those with p53-positivity and DNA aneuploidy was significantly worse than that for patients with any other combination (P = 0.02). Conclusion. No survival benefit was observed with the combined chemotherapeutic regimens compared with FU alone. p53 positivity was negatively correlated to survival for node-positive and stage III patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012066
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  • 6
    Electronic Resource
    Electronic Resource
    Organ-Derived Dependence of Biomineralization in Type I Collagen Gel (2000)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 192-195 (Sept. 2000), p. 709-712 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/45/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.192-195.709.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative chromosome maps and rDNA localization in the T subgenome of Nicotiana tabacum L. and its putative progenitors (2000)
    Springer
    Theoretical and applied genetics 101 (2000), S. 1180-1188 
    Details
    ISSN: 1432-2242
    Keywords: Key words Quantitative idiogram ; Prometaphase chromosome ; Image analysis ; Fluorescence in situ hybridization ; T subgenome progenitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Using DAPI-stained prometaphase chromosomes, quantitative idiograms were constructed for the T subgenome of Nicotiana tabacum (2n = 4x = 48, SSTT) and two putative candidates for its T subgenome progenitor, Nicotiana otophora and Nicotiana tomentosiformis (both have 2n = 24, TT). The large chromosomes of the three karyotypes could be identified from the distributional pattern of the DAPI signal. Fluorescence in situ hybridization (FISH) with 5S rDNA gave not only good cytogenetical landmarks for identification of small chromosomes of the karyotypes but also phylogenetical information. In all three idiograms, 5S rDNA was localized in the proximal region of the long arm of a small submetacentric pair, but an additional 5S rDNA locus was detected terminally on the short arm of a small metacentric pair in N. otophora. The 18S rDNA locus detected here corresponded to satellite regions in all three karyotypes. Two satellited pairs in N. otophora and one satellited pair in N. tomentosiformis had single large subterminal DAPI blocks and two interstitial DAPI bands on their long arms, respectively. For the T subgenome component of N. tabacum, the single intense DAPI band was depicted on the center of the long arm of a satellited pair in the idiogram, although two interstitial bands were often detected on the long arm of the satellited pair in some spreads. Therefore, it was suggested that the T component of N. tabacum was more similar to that of N. tomentosiformis than N. otophora, especially in respect of the number and location of rDNA and the distributional patterns of DAPI signals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051595
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  • 8
    Electronic Resource
    Electronic Resource
    Subsite-specific risk factors for hypopharyngeal and esophageal cancer (Japan) (2000)
    Springer
    Cancer causes & control 11 (2000), S. 597-608 
    Details
    ISSN: 1573-7225
    Keywords: esophageal cancer ; hypopharyngeal cancer ; Japan ; risk factors ; subsite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To clarify subsite-specific risk factors for hypopharyngeal and esophageal cancers (HC and EC), we concluded a hospital-based case–referent study in Nagoya, Japan. Methods: Subjects comprised 346 male cases with cancer of the hypopharynx (n = 62) or esophagus (upper [U-EC] 53, middle [M-EC] 159, lower [L-EC] 72), and 11,936 male referents free from cancer among first-visit outpatients aged 40–79 years in 1988–1997. Of histological confirmed cases, 93% comprised squamous cell carcinoma. Odds ratios (ORs) were estimated by a logistic regression model with adjustment for potential confounding factors. Results: Cigarette smoking increased the OR for M-EC, and alcohol drinking elevated the ORs for all subsites. The trend of ORs for combined cases of M- and L-EC tended to increase with number of cigarettes (p = 0.056), and a decreasing trend of the ORs was found with years after quitting smoking (p = 0.006). The ORs for smoking with drinking were multiplicatively greater than those for smoking or drinking in combined cases of HC and EC. In contrast, daily raw vegetable consumption lowered the ORs for all subsites. Conclusions: This study suggests that the magnitude of risk with smoking is stronger for M-EC within the esophagus, and drinking increases the risk at any subsite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008909129756
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis of large-surface area silica-modified titania ultrafine particles by the glycothermal method (2000)
    Springer
    Journal of materials science 19 (2000), S. 1439-1443 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006723422629
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  • 10
    Electronic Resource
    Electronic Resource
    Reactions of rare earth acetate hydrates in glycols at high temperatures (2000)
    Springer
    Journal of materials science 35 (2000), S. 1541-1547 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The reaction of rare earth acetate hydrate in ethylene glycol at 300°C yielded two novel crystalline products, one from La-Gd and the other from Tb-Lu and Y. IR and NMR spectra of these products suggested the presence of both acetate groups and ethylene glycol moieties, and it was concluded that these products are ethylene glycol complexes of rare earth acetate (hydroxide) oxide. On the other hand, the reaction of rare earth acetate hydrate in other glycols such as 1,3-propanediol and 1,4-butanediol yielded rare earth diacetate hydroxide, two morphs of rare earth acetate oxide and rare earth acetate dihydroxide, depending on the ionic size of rare earth element, but the glycol complexes were not formed. In all cases, acetate groups of rare earth acetate were not completely eliminated from the coordination sites of the rare earth element by the reaction in glycols but the reaction in ethylene glycol could liberate the acetate groups more easily than other glycols because of high coordination ability of ethylene glycol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004709803248
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