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  • 1
    Electronic Resource
    Electronic Resource
    A case of cold-dependent exercise-induced anaphylaxis (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Exercise-induced anaphylaxis (EIA) is a form of physical urticaria that is induced by exercise. A 16-year-old Japanese boy had a 4-year history of recurrent wealing and dyspnoea after physical exercise such as jogging, playing handball or riding a bicycle in winter. The episodes were not associated with ingestion of foods including wheat or soya bean. A provocation test, with 15 min of exercise and 2 min of cold stimulation immediately before or immediately after the exercise, elicited a weal that was localized to the test area. A challenge test with ingestion of boiled soya beans and exercise did not elicit a weal. Therefore, in this case, cold exposure, but not food ingestion, was essential for inducing EIA. Cold-dependent EIA is different from cold urticaria, food-dependent EIA, cholinergic urticaria and cold-induced cholinergic urticaria, and may be a distinct entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04789.x
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  • 2
    Electronic Resource
    Electronic Resource
    Altered Expression of p53 mRNA in the Brain and Pituitary During Repeated Immobilization Stress: Negative Correlation with Glucocorticoid Receptor mRNA Levels (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 16 (2004), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In our previous study, apparent reduction of glucocorticoid receptor (GR) mRNA was seen in the hippocampus and the hypothalamic paraventricular nucleus (PVN) during repeated immobilization (IMO) stress, but not following starvation. Our laboratory has also shown that the sp1 activates, whereas tumour suppressor p53 represses the promoter activity of GR gene. In an attempt to reveal the possibility that transcription factors such as sp1 and/or p53 are involved in the regulation of GR mRNA expression in the hippocampus and in the PVN in vivo, we examined the expression of GR mRNA, p53 mRNA, and sp1 mRNA in the hippocampus and in the PVN during repeated IMO and following starvation. In addition, the expression of these mRNAs was examined in the anterior pituitary, another GR-rich area. GR mRNA in all subfields of the hippocampus was robustly decreased, while GR mRNA in the anterior pituitary was increased, 24 h following 4 × IMO (2 h daily, for 4 consecutive days) and immediately after 5 × IMO. GR mRNA in the PVN was significantly decreased immediately after 5 × IMO, but not at 24 h after 4 × IMO. Conversely, p53 mRNA in the PVN and hippocampus was increased, whereas p53 mRNA in the anterior pituitary was decreased, 24 h following 4 × IMO and immediately after 5 × IMO. Sp1 mRNA was unchanged in all areas examined following repeated IMO. Following 4 days of starvation, neither GR mRNA, p53 mRNA nor sp1 mRNA showed any changes in the PVN and the hippocampus, except there was a minor decrease in GR mRNA in CA1-2. In the anterior pituitary, 4 days of starvation induced a minor, but significant increase in GR mRNA, whereas it decreased p53 mRNA. Overall, regression analyses revealed a negative correlation between GR mRNA levels and p53 mRNA levels in CA1-2 and dentate gyrus of the hippocampus and in the anterior pituitary. GR mRNA in the PVN also showed a tendency towards the negative correlation with p53 mRNA levels. The results raise the possibility that p53 negatively regulates GR mRNA expression in the PVN, the hippocampus and the anterior pituitary during repeated immobilization stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.2004.01131.x
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  • 3
    Electronic Resource
    Electronic Resource
    Transcriptional Regulation of Serum Amyloid A1 Gene Expression in Human Aortic Smooth Muscle Cells Involves CCAAT/Enhancer Binding Proteins (C/EBP) and is Distinct From HepG2 Cells (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 56 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Regulation of acute-phase serum amyloid A (A-SAA) synthesis by proinflammatory cytokines and steroid hormones in human aortic smooth muscle cells (HASMCs) is distinct from that in HepG2 cells. To study the cis- and trans-activating promoter element involved in the SAA1 gene expression by HASMCs and HepG2 cells, we constructed plasmid vectors for luciferase reporter gene assay with varying lengths of SAA1 upstream regulatory region (up to 1431 bp), and examined their response to proinflammatory cytokines and/or steroid hormones. The corresponding vectors with the SAA4 upstream regulatory region served as controls. The presence of proposed transcriptional regulatory factors binding to these regions was confirmed immunohistochemically.The sequences of 1478 and 1836 bp of the SAA1 and SAA4 5′-flanking regions were determined, respectively. SAA1 promoter transcription in cultured HASMCs was upregulated not by proinflammatory cytokines, but rather by glucocorticoids. This differed from HepG2 cells, in which SAA1 promoter transcription was upregulated synergistically by proinflammatory cytokines and glucocorticoids. The promoter activity of a series of truncated SAA1 promoter constructs measured using the reporter gene assay showed that the 5′-region from −252 to −175, containing a consensus site for CCAAT/enhancer binding proteins α,β (C/EBPα,β), was essential for SAA1 induction in HASMCs. In HepG2 cells, the 5′-region from −119 to −79, containing a nuclear factor kappa-B (NFκB) consensus sequence, was essential for the induction. The functional significance of the C/EBP site as indicated by the immunohistochemical result was that in HASMCs anti-C/EBPβ reactivity was shifted from the cytoplasm to the nuclei.We have, therefore, demonstrated that the region containing the C/EBPα,β consensus binding site between the bases −252 and −175 is important for the glucocorticoid-induced SAA1 gene expression in HASMCs but not in HepG2 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01169.x
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  • 4
    Electronic Resource
    Electronic Resource
    Asymmetry in jaw-jerk reflex latency in craniomandibular dysfunction patients with unilateral masseter pain (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of the present study was to elucidate the effects of unilateral masseter muscle pain on the jaw-jerk reflex. The latency and peak-to-peak amplitude of bilateral electromyographic activity recorded at the masseter muscles during the jaw-jerk reflex were measured in 18 patients with craniomandibular dysfunction (CMD) with strictly unilateral masseter pain or tenderness and 10 control subjects using a computerized recording and analysis system. The reflex was elicited, at the mandibular rest position, by tapping the centre of the chin downwards with a reflex hammer incorporating a microswitch that triggered the sweep of the recording apparatus upon contact with the chin. In the CMD group, the jaw-jerk latency on the affected side (6·89±0·98 ms) was significantly shorter (P〈0·01) than that on the unaffected side (7·59±0·92 ms). In the control group, there was no difference between the jaw-jerk latencies on the right (7·06±0·64 ms) and the left (7·08±0·65 ms) sides. The range of side asymmetry for jaw-jerk latencies in the CMD group was greater than that in the control group. In six patients, the latency difference exceeded 1 ms. The asymmetry of latency of the jaw-jerk reflex was thought to be due to facilitation on the side with masseter pain or tenderness. This facilitation on the ipsilateral side might be produced by enhanced gamma drive induced by sustained nociceptive stimulation. Such effects may be related with clinically derived concepts regarding such muscle dysfunction as myospastic activity or trigger points.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2000.00595.x
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  • 5
    Electronic Resource
    Electronic Resource
    Ebselen Decreases Ozone-Induced Pulmonary Inflammation in Rats (2000)
    Springer
    Lung 178 (2000), S. 225-234 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Ozone—Pulmonary inflammation—Ebselen—Peroxynitrite.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We studied the effects of ebselen on rat lung inflammatory responses against ozone exposure. Rats were treated with ebselen every 12 h from 1 h before a single 4-h exposure to 2 ppm ozone. Treatment with ebselen (10 mg/kg) significantly decreased pulmonary inflammation as indicated by the albumin concentration and the number of neutrophils in the bronchoalveolar lavage fluid 18 h after the ozone exposure. Although treatment with ebselen did not alter the macrophage expression of inducible nitric oxide synthase after the ozone exposure, it did markedly inhibit the nitration reaction of tyrosine residues, suggesting that ebselen scavenges peroxynitrite during ozone-induced pulmonary inflammation. Treatment with ebselen also enhanced the pulmonary expression of both copper, zinc, and manganous superoxide dismutases at the same time point. These enzymes may also contribute to a decrease in the formation of peroxynitrite by lowering the concentration of superoxide. Thus, ebselen represents a useful compound for protecting against certain acute lung injuries by modulating the oxidant-related inflammatory process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004080000026
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  • 6
    Electronic Resource
    Electronic Resource
    Recent Achievements and Future Challenges in SiC Homoepitaxial Growth (2002)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 389-393 (Apr. 2002), p. 165-170 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/06/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.389-393.165.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    A segment concept in the dissolution of stereoregular isotactic polyacrylonitrile into three dinitrile solvents, CN-(CH2) n -CN (n = 1, 2, and 3), at elevated temperatures (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 352-357 
    Details
    ISSN: 1435-1536
    Keywords: Key words Isotactic polyacrylonitrile ; High-temperature dissolution ; Dinitrile solvents ; Segment mobility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The dependence of the dissolution temperature (T sol) of isotactic polyacrylonitrile (PAN) on tacticity was studied for three dinitrile solvents. A linear relationship was obtained in the inverse plots of the tacticity dependence of the T sol of PAN. A phenomenological analogy between the tacticity dependence of the T sol of isotactic PAN and the molecular-weight dependence of the glass-transition temperature of amorphous polystyrene is discussed from a thermodynamic point of view. The linear relationships in both phenomena are explained in terms of a common mechanism: a breakdown of thermodynamic competition, enthalpy, and entropy through the segment mobility. The significance of segment concept and molecular mobility at elevated temperatures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050524
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  • 8
    Electronic Resource
    Electronic Resource
    Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue (2000)
    Springer
    Journal of human genetics 45 (2000), S. 374-377 
    Details
    ISSN: 1435-232X
    Keywords: Key words Cell motility ; Binder of Rho GTPase ; CDC42 TC10 ; Borg4 ; Full-length cDNA ; Fluorescence in situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Borg (binder of Rho GTPases) family proteins interact with CDC42 and TC10 in a guanosine triphosphate (GTP)-dependent manner. We have isolated a full-length cDNA of the mouse Borg4 gene, which is a member of this family. Sequence analysis revealed that this gene encoded a putative 349-amino acid protein. By reverse transcription — coupled polymerase chain reaction (RT-PCR) analysis, we observed that Borg4 was expressed ubiquitously in adult tissues. Additionally, we determined the entire cDNA sequence of the putative human Borg4 orthologue. By fluorescence in situ hybridization, mouse Borg4 and the putative human orthologue have been assigned to mouse chromosome 11E and human chromosome 17q24–25, which has been described as syntenic to the mouse region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070012
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  • 9
    Electronic Resource
    Electronic Resource
    A novel interstitial deletion of KAL1 in a Japanese family with Kallmann syndrome (2000)
    Springer
    Journal of human genetics 45 (2000), S. 237-240 
    Details
    ISSN: 1435-232X
    Keywords: Key words Kallmann syndrome ; KAL1 ; Mutation ; Anosmia ; Hypogonadism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We identified a novel interstitial deletion that spanned from exons 5 to 10 of KAL1 in two Japanese brothers with X-linked Kallmann syndrome (KS; MIM no. 308700). Both brothers had hypogonadism, unilateral renal agenesis, and disturbance of the sense of smell, but they had no other neurological manifestations, including mental disturbance. Their mother was confirmed to be an asymptomatic carrier, by use of a comparative multiplex polymerase chain reaction (PCR) analysis. The present patients are further examples of patients with KS without mental disturbance caused by a mutation confined to KAL1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070033
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