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  • 1
    Electronic Resource
    Electronic Resource
    Patterns of regular drug use in Spanish childbearing women: changes elicited by pregnancy (1998)
    Springer
    European journal of clinical pharmacology 54 (1998), S. 645-651 
    Details
    ISSN: 1432-1041
    Keywords: Key words Drug use ; Pregnancy ; Analgesics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To determine drug use in Spanish women before pregnancy and from conception to the awareness of pregnancy (early period of pregnancy, EPP), as well as to analyse attitudinal changes when pregnancy was planned or known. Methods: Trained gynaecologists used a structured questionnaire to collect demographic and obstetric characteristics, histories of regular drug taking before pregnancy, attitudes towards drug taking during pregnancy and current drug use in the EPP. Women were interviewed at their first antenatal visit during the first trimester. Results: Two hundred and seventy-two women were included (mean age 29.3 years and 66.3 days of gestation). Before pregnancy, 24% regularly took drugs, 70% of them more than twice a week; a significantly higher frequency was found in those receiving public antenatal care and in those who had had less education. In 39% of women, awareness of pregnancy did not change their attitudes towards regular drug use. Among those who decided to suppress their regular drug intake, 58% did so when their pregnancy was confirmed and 42% when they planned it. In women who planned their pregnancy, 30.1% stopped when they tried to become pregnant. However, 62% of all women took drugs during the EPP. In private antenatal care significantly more drugs were taken per patient. By the 168 women 278 compounds were consumed during the EPP: 40% were analgesics (mainly paracetamol and acetylsalicylic acid) and 25% were digestive and metabolic drugs (mainly antacids and laxatives). Drugs were often used more than twice a week, particularly in women receiving public antenatal care and in those who had had less education. Conclusion: Drug taking is common in Spanish women of childbearing age, and many of those in our study did not decide to stop during the EPP. Few women avoid drugs when planning a pregnancy. Therefore, gynaecologists must advise against drug taking in patients who wish to become pregnant and suggest that unnecessary drug use be avoided when the pregnancy is already diagnosed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050528
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  • 2
    Electronic Resource
    Electronic Resource
    Mucosal mantle cell (centrocytic) lymphomas (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 26 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The morphology, phenotype, genotype and clinical behaviour of four cases of mantle cell lymphoma (centrocytic lymphoma) presenting primarily in mucosa (two gastric, one in large bowel and one tonsillar) are reviewed. Their relationship with the broader group of mantle cell and mucosa-associated lymphoid tissue (MALT) lymphomas is also discussed. All four tumours showed a monomorphic picture of mantle cells (centrocytes) arranged in a diffuse, or vaguely nodular, pattern. Scattered non-neoplastic germinal centres were entrapped within the tumour cells, although there was no follicular colonization. In two cases distinct epithelial infiltration by tumour cells was observed. All four tumours had a CD19, CD20, CDS, IgD, Leu8 immunophenotype, whereas KiM1P and CD10 expression were absent. DRC antibody showed loose aggregates of dendritic cells in three of four cases. Three cases showed PRAD-1/Cyclin D1 overexpression by Northern blot analysis. Although we were not able to detect bcl-1 rearrangement in the major translocation cluster (MTC) breakpoint, the possibility of bcl-1 rearrangement involving other cluster breakpoints cannot be ruled out. The four cases evolved as a disseminated disease, involving either peripheral lymph nodes, spleen or bone marrow. The biological behaviour of mantle cell lymphoma presenting in mucosa appears, irrespective of localization or macroscopic presentation, similar to that of nodal mantle cell lymphoma. Their tendency to dissemination contrasts with MALT lymphomas, which tend to remain localized, and from which mucosa mantle cell lymphoma must be distinguished. The presence of lymphoepithelial lesions does not seem to be a useful differential feature, since occasional epithelial infiltration was seen in two cases. Reactivity with CD5 appears to be especially useful in distinguishing these, since all four cases were clearly positive, in contrast with what is usually found in MALT lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00248.x
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  • 3
    Electronic Resource
    Electronic Resource
    Focus expansion of bean rust in cultivar mixtures (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 44 (1995), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Radial expansion of foci in mixtures of susceptible and resistant bean cultivars was studied at two sites in Ethiopia. The foci expanded in a wave-like fashion. At Ambo (1990), radial expansion velocity ranged from 6 cm per day in mixtures with 20% susceptible plants to 15 cm per day in plots with the susceptible plants only. At Debre Zeit, the velocity ranged from 3 cm per day in a mixture with 20% susceptible plants to 16 cm per day in plots with 100% susceptible plants. At both sites the radial expansion velocity of foci correlated linearly with the logarithm of the fraction of susceptible plants in the mixture. Velocities of focus expansion at Ambo and Debre Zeit were approximately equal in plots consisting of susceptible plants only. At lower proportions of susceptible plants the velocities at Debre Zeit were lower than at Ambo. Indications were given as to the environmental factors responsible for the observed difference between sites. At each site, the variation between plots showed a clear spatial pattern, probably due to environmental factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1995.tb01672.x
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  • 4
    Electronic Resource
    Electronic Resource
    p53-Mutationen/ p53-Proteinüberexpression Differentielle Bedeutung für die Progression von Kopf-Hals-Karzinomen* (1999)
    Springer
    HNO 47 (1999), S. 833-848 
    Details
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050470
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  • 5
    Electronic Resource
    Electronic Resource
    Correlation between the presence of anti HPV33 VLP antibodies and HPV DNA in cervical neoplasia patients (1997)
    Springer
    Archives of virology 142 (1997), S. 413-416 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. The L1 capsid proteins derived from human papillomavirus (HPV) type 33 were expressed in a recombinant baculovirus system using Sf9 insect cells. Selected sera originating in women from case-control study carried out in Spain and Colombia found negative and positive for HPV16, 18, 31, 33 and 35 DNA were tested in ELISA for the presence of IgG antibodies to purified virus-like particles (VLP). The reactivity was type-restricted with the possible exception of HPV31.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050087
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  • 6
    Electronic Resource
    Electronic Resource
    Expression von Zellzykluskomponenten in fortgeschrittenen Kopf-Hals-Karzinomen Bedeutung für die Prognose nach primärer akzelerierter Radiochemotherapie (1999)
    Springer
    HNO 47 (1999), S. 777-786 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Kopf-Hals-Tumoren ; Prognostische Faktoren ; Radiochemotherapie ; Zellzyklusproteine ; Key words Head and neck tumors ; Radiochemotherapy ; Prognostic factors ; Cell-cycle regulatory proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Primary radiochemotherapy is gaining increasing importance for the treatment of advanced head and neck squamous cell carcinomas. However, there is a lack of clinical factors concerning prognostic information in relation to treatment. In this pilot study, we examined whether molecular factors can provide such information. Patients and methods: The expression patterns and their possible prognostic relevance of the cell cycle regulatory proteins p53, p21WAF/CIP1, Rb, p16INK4A, CDK4 and Cyclin D1, MIB1 (Ki-67) and BCL-2 were analysed in pretreatment tumor biopsies from 43 patients with advanced carcinomas of the oropharynx (n=26), hypopharynx (n=10) and larynx (n=7) by applying immunohistochemistry to paraffin sections of tumor specimens. All patients were treated by the same method of an accelerated ”concomitant boost” radiochemotherapy with carboplatin in a phase II study. Median followup time was 56 months. Results: No correlation was found between any of the markers and the remission rate, T-stage, N-stage, rate of loco-regional recurrences and distant metastases. However, independent of the tumor stage, patients with CDK4/cyclin-D1 overexpressing tumors had a significantly shortened overall survival (P=0.014 and 0.026, respectively). Conclusion: The results of this pilot study indicate that CDK4 and cyclin D1 over-expression provide useful prognostic information about clinical outcome after primary radiochemotherapy of head and neck cancer patients.
    Notes: Zusammenfassung Hintergrund: Bei fortgeschrittenen Kopf-Hals-Karzinomen wird in zunehmendem Maße die primäre Radiochemotherapie einer primär operativen Therapie vorgezogen. Klinische prognostische Faktoren für die Krankheitsverläufe nach primärer Radiochemotherapie fehlen jedoch. Die vorliegende Pilotstudie sollte klären, ob molekulare Faktoren prognostische Aussagen liefern können. Patienten und Methoden: In prätherapeutischen Biopsien von 43 Patienten mit fortgeschrittenen Karzinomen wurde die Expression der Zellzykluskomponenten p53, p21WAF/CIP1, Rb, p16INK4A, CDK4 und Cyclin D1, des Proliferationsmarkers MIB1 und des apoptosehemmenden Proteins BCL-2 immunhistochemisch bestimmt. Die Patienten wurden nach dem Protokoll einer akzelerierten „Concomitant-boost-Radiochemotherapie” mit Carboplatin im Rahmen einer Phase-II-Studie behandelt. Die mediane Beobachtungszeit zum Analysezeitpunkt betrug 56 Monate. Ergebnisse: Keiner der Marker korrelierte mit dem Tumorstadium und N-Status, den Remissionsraten nach Therapieende oder dem posttherapeutischen Auftreten von Rezidiven, Metastasen und Zweitkarzinomen. Dahingegen hatten Patienten mit CDK4- und Cyclin D1-überexprimierenden Tumoren unabhängig vom Tumorstadium eine signifikant kürzere Gesamtüberlebenszeit (p=0,014 bzw. 0,026). Schlußfolgerung: Die Ergebnisse der Pilotstudie indizieren eine prognostische Bedeutung der Überexpression von CDK4 und Cyclin D1 nach primärer Radiochemotherapie von fortgeschrittenen Kopf-Hals-Karzinomen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050460
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  • 7
    Electronic Resource
    Electronic Resource
    Onkogene humane Papillomaviren Schlüsselrolle bei Plattenepithelkarzinomen der Tonsillen mit Defekt im Retinoblastomprotein* (1999)
    Springer
    HNO 47 (1999), S. 796-803 
    Details
    ISSN: 1433-0458
    Keywords: Schüsselwörter Tonsillenkarzinome ; Onkogene humane Papillomaviren (HPV) ; Retinoblastomprotein (pRb) ; Prognose ; Key words Tonsillar squamous cell carcinomas ; Oncogenic human papillomavirus ; Retinoblastoma protein ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In order to identify squamous cell carcinomas of the head and neck (HNSCC) with common biological and clinical features, we investigated the incidence and properties of carcinomas lacking retinoblastoma protein (pR6) cell cycle control. Of 208 HNSCC investigated, 23 (11%) showed a lack of pRb expression. The majority of these tumors (65%) were tonsillar carcinomas. The pRb-negative tonsillar tumors were all stage IV, had metastasized to lymph nodes at the time of diagnosis and were in general poorly differentiated or undifferentiated. Very significantly, the pRb-negative phenotype was strongly associated with the presence of oncogenic human papilloma viruses, implying a viral etiology and functional inactivation of pRb by the viral E7 oncoprotein. Despite the very adverse histopathological factors, patients with pRb-negative tonsillar carcinomas had a better clinical outcome, which was consistent with a uniform favorable responsiveness of these tumors to postoperative radiation therapy.
    Notes: Zusammenfassung Hinsichtlich biologischer Tumorcharakteristika, Genese und klinischen Eigenschaften von Plattenepithelkarzinomen im Kopf-Hals-Bereich bestehen viele Unklarheiten. Zur besseren Charakterisierung dieser Karzinome wurde geprüft, ob es Tumoren mit Defekten im Retinoblastomstoffwechsel gibt und ob weitere molekulare und klinische Gemeinsamkeiten vorliegen. Bei 11% der untersuchten Plattenepithelkarzinome des Kopf-Hals-Bereichs (23 von 208) lag ein Defekt im Retinoblastomstoffwechsel vor; 15 dieser 23 Tumoren (65%) waren in der Tonsille lokalisiert. Die pRb-negativen Tumoren lagen überwiegend als Stadium IV (UICC) vor, hatten bereits in regionäre Lymphknoten metastasiert und wiesen eine geringgradige Differenzierung auf. Dagegen waren klinische Verläufe und Gesamtüberlebenszeiten nach Operation und Strahlentherapie günstig. Die molekularbiologischen Analysen zeigten folgende Gemeinsamkeiten innerhalb dieser Gruppe der Tonsillenkarzinome: Der Retinoblastom-Protein (pRb)- und Cyclin-D1-Spiegel waren erniedrigt, p16INK4a erhöht. Es zeigte sich eine starke Assoziation mit onkogenen humanen Papillomaviren (HPV), durch deren Onkogen E7 wahrscheinlich die pRb-Inaktivierung erfolgt. Damit kommt den Papillomaviren eine wesentliche Rolle für die Entstehung und besonderen klinischen Eigenschaften dieser Tonsillenkarzinome zu.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050462
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  • 8
    Electronic Resource
    Electronic Resource
    Needle Arthroscopy of the Knee with Synovial Biopsy Sampling: Technical Experience in 150 Patients (1999)
    Springer
    Clinical rheumatology 18 (1999), S. 434-441 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Arthritis, Arthroscopy, Histology, Synovitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Needle arthroscopy is an office-based technique allowing direct visualisation of the knee cavity and selective sampling of the synovial membrane. We performed needle arthroscopy in 150 patients with synovitis of the knee (1) to evaluate the diagnostic potential in early arthritis, (2) to perform therapeutic lavage in persistent inflammatory synovitis and (3) to assess the balance between technical feasibility, safety and patient comfort on the one hand, and the relevance of the obtained macro- and microscopic information for diagnosis and research purposes on the other. After disinfection of the leg and local anaesthesia of the skin and joint, a 1.8–2.7 mm needle arthroscope was introduced into the knee. Synovial fluid was aspirated and lavage of the joint cavity was performed to allow macroscopic evaluation of hyperaemia and hypertrophy of the synovial membrane. Biopsies were taken at inflamed sites, followed by another lavage to remove blood and debris. Needle arthroscopy of the knee is a simple and easy to perform technique made particularly attractive by the local anaesthesia and the ambulatory setting. It allows good macroscopic evaluation of synovial inflammation and selective sampling of the synovial membrane. Biopsies are suitable for RNA and DNA extraction, bacterial or lymphocyte culture, and cell isolation. Because samples were sometimes too small for representative histology, we switched from a 1.8 mm to a 2.7 mm biopsy forceps with good results. In nearly all cases the arthroscopy was well tolerated. Moreover, some patients reported relief of symptoms and even improvement of mobility after lavage of the inflamed joint. No major complications were noted. It was concluded that needle arthroscopy of the knee is a simple, safe and well-tolerated technique, with promising perspectives as a diagnostic, scientific and possibly therapeutic tool in rheumatic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050134
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  • 9
    Electronic Resource
    Electronic Resource
    Peripheral T-cell lymphomas: Initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification (1998)
    Springer
    Annals of oncology 9 (1998), S. 849-855 
    Details
    ISSN: 1569-8041
    Keywords: peripheral T-cell lymphomas ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries. The aim of the present study is to analyze the initial characteristics and prognostic factors in a large series of PTCL patients. Patients and methods: 174 patients (105 male/69 female; median age 61 years) were diagnosed with PTCL according to the R.E.A.L. Classification in nine Spanish institutions between 1985 and 1996. Cutaneous lymphomas and T-cell chronic lymphocytic/prolymphocytic leukemia were excluded from the study. Univariate and multivariate analyses were used to assess the prognostic value of the main initial variables. Results: The distribution according to histology subgroup was: PTCL unspecified, 95 cases (54.4%); anaplastic large-cell Ki-1-positive (ALCL), 30 cases (17%); angioimmunoblastic T cell, 22 cases (13%); angiocentric, 14 cases (8%); intestinal T cell, 12 cases (7%), and hepatosplenic γδ T cell, one case (0.6%). As compared to the other types, ALCL presented more frequently in ambulatory performance status, without extranodal involvement, in early stage, normal serum β2-microglobulin (B2M) level and low-risk international prognostic index (IPI). Most patients were treated with adriamycin-containing regimens. The overall CR rate was 49% (69% for ALCL vs. 45% for other PTCL; P 〈 0.02). The risk of relapse was 48% at four years. Median survival of the series was 22 months (65 months for ALCL vs. 20 months for other PTCL; P = 0.03), with a four-year probability of survival of 38% (95% confidence intervals (95% CI): 28–48). In the univariate analysis, in addition to the histology, older age, poor performance status, presence of B-symptoms, extranodal involvement, bone marrow infiltration, advanced Ann Arbor stage, high serum LDH, high serum B2M, and intermediate- or high-risk IPI were related to poor survival. In the multivariate analysis the histologic subgroup (ALCL vs. other PTCL) (P = 0.02; response rate (RR): 4.3), the presence of B-symptoms (P = 0.02, RR: 2.2), and the IPI (low vs. high) (P = 0.04, RR: 2) maintained independent predictive value. When the analysis was restricted to the unspecified subtype, only IPI had independent prognostic value (P = 0.003; RR: 3.5). Conclusions: PTCL have adverse prognostic features at diagnosis, respond poorly to therapy and have short survival, with no sustained remission. ALCL constitutes a subgroup which responds better to therapy and has a longer survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008418727472
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  • 10
    Electronic Resource
    Electronic Resource
    B-cell chronic lymphocytic leukemia: Recent progress in biology, diagnosis, and therapy (1997)
    Springer
    Annals of oncology 8 (1997), S. 93-101 
    Details
    ISSN: 1569-8041
    Keywords: B-cell chronic lymphocytic leukemia ; CLL biology ; CLL diagnosis ; CLL therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract B-cell chronic lymphocytic leukemia (CLL) is a highly common form ofleukemia characterized by the accumulation of long-lived, functionallyinactive, mature appearing neoplastic B lymphocytes. In addition, immunedisturbances such as hypogammaglobulinemia and autoimmune phenomena(particularly, autoimmune hemolytic anemia) are frequently found in CLLpatients [1–2]. The etiology of CLL is unknown. In contrast with otherleukemias, there is no relationship between CLL and exposure to radiation orother cytotoxic agents. A genetic basis is highly likely since there aredifferences in the incidence of CLL in different countries (e.g., CLL accountsfor 30%–40% of all the leukemias in Western countries ascompared to 5%–10% in Asian countries) and the risk ofcontracting CLL is higher among persons with first-degree relatives with thedisease [3]. Because the incidence of CLL increases with age and the longer lifeexpectancy of the general population, the age of patients at diagnosis isincreasing. The median age at diagnosis is now about 70 years, with onlyone-third of the patients being less than 60 years of age. In the majority ofthe series, males predominate over females in a proportion of 1.5/1. Theprognosis of patients with CLL is variable. However, clinical stages and otherprognostic factors allow the individual risk of each patient to be assessedvery accurately, which is useful for making treatment decisions. In the past two decades, significant progress has been made in CLL[4–10]. This review summarizes recent advances in the biology,diagnosis, and therapy of CLL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008222405042
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