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  • 1
    Electronic Resource
    Electronic Resource
    Osteoregenerative lateral suboccipital craniectomy using fibrin glue (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 446-452 
    Details
    ISSN: 0942-0940
    Keywords: Craniectomy ; fibrin glue ; occipital bone ; osteoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes a simple technique of cranioplasty for suboccipital craniectomy and the results of a clinical study to assess the effects of fibrin glue on regeneration of the skull. Cranioplasty using a mixture of autologous bone chips and human allogenic fibrin glue was performed in 31 patients who received lateral suboccipital craniectomy. Long-term observations with three-dimensional CT showed satisfactory reconstruction of the mastoid-occipital bone plate in 25 patients (81%); among them, a nearly complete reconstruction of the occipital bone (plate) was found in 14 patients. Regeneration of the bone began 6 months after surgery on the inner surface, adjacent to the dura mater. In conclusion, the present technique provides a new simple method to restore an autologous bone plate in a cranial defect made by piecemeal craniectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808882
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  • 2
    Electronic Resource
    Electronic Resource
    Suppression of tumour necrosis factor-α expression in leprosy skin lesions during treatment for leprosy (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The expression of tumour necrosis factor (TNF)-α in leprosy skin lesions was examined before and during successful treatment in a patient with borderline lepromatous leprosy. Before treatment, immunohistochemical staining of a skin biopsy specimen showed diffuse TNF-α deposits in granulomas and significant TNF-α deposits on infiltrated mononuclear cells. After 1 year's treatment, the skin lesions exhibited a reduction in granulomas, and a concomitant reduction in deposits of TNF-α.Furthermore, the level of expression of TNF-α messenger RNA. as examined using a reverse transcriptase-polymerase chain reaction method, was reduced markedly after treatment. These findings provide evidence for a correlation between the expression of TNF-α and disease activity suggesting that TNF-α is a useful prognostic indicator for inflammation in leprosy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.d01-1208.x
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  • 3
    Electronic Resource
    Electronic Resource
    Hereditary angioedema caused by a point mutation of exon 7 in the Cl inhibitor gene (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Hereditary angioedema (HAE) is a genetic disease which may be detected serologically. We present a patient with HAE in whom we examined the gene defect using the polymerase chain reaction. The patient presented with recurrent episodes of abdominal pain, or non-itchy swellings of the hands, feet, and penis. The serum levels of C1 inhibitor (C1-INH and C4 were below normal. We determined that a single base change (C-T) at nucleotide 1482 in the seventh exon was present in the C1-INH gene. This mutation converted the codon for the Gln-339 to a premature translation termination codon TAG. A point mutation in the C1-INH gene can cause type I HAE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb06980.x
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  • 4
    Electronic Resource
    Electronic Resource
    Requirement of CD80 and CD86 Molecules for Antigen Presentation by Eosinophils (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 44 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The authors analysed the antigen-presenting ability of eosinophils purified from peritoneal exudate cells of interleukin-5 (IL-5) transgenic mice. The granulocyte-macrophage colony-stimulating factor (GM-CSF)-treated eosinophils induced proliferative responses of primed lymph node T cells and thymus T cells to staphylococcal enterotoxin B (SEB), while untreated eosinophils induced little or no response. GM-CSF-treated eosinophils also induced proliferation of ovalbumin (OVA)-primed lymph node T cells to OVA. Although untreated eosinophils expressed no MHC class II molecule on the surface the eosinophils could be induced to express major histocompatibility complex (MHC) class II molecules when treated with GM-CSF. In the present study, anti-I-Ak monoclonal antibodies (MoAbs) strongly inhibited proliferation of thymus T cells and proliferation of OVA-primed lymph node T cells in response to OVA, but weakly inhibited proliferation of primed T cells in response to SEB. Furthermore, CD80 (B7-1) and CD86 (B7-2) were expressed on the surfaces of untreated eosinophils. The expression of those two molecules on the eosinophils was increased by incubation with GM-CSF. Moreover, anti-CD80 or anti-CD86 MoAbs blocked proliferative responses of primed lymph node T cells and thymus T cells to SEB, and also blocked responses of primed lymph node T cells to OVA. Thus, CD80 and CD86 play an important role in stimulation of T cells by eosinophils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-303.x
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  • 5
    Electronic Resource
    Electronic Resource
    Diacetyl fermentation coupled with pervaporation using oleyl alcohol supported liquid membrane (1995)
    Springer
    Bioprocess engineering 13 (1995), S. 119-123 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Pervaporation using oleyl alcohol supported liquid membrane was successfully applied to diacetyl fermentation by immobilized lactic acid bacteria. Diacetyl productivity was about 10 g⋅m-3⋅h-1, while productivity during batch fermentation was about 6 g⋅m-3⋅h-1. Diacetyl yield from consumed glucose was about 0.04 g⋅g-1 which was 4 times as large as that of batch fermentation. The pervaporation functioned favorably on actual fermentation broth. The flux of the permeate and the diacetyl separation factor for the pervaporation were about 9 g⋅m-2⋅h-1 and 36, respectively, and these values were maintained at almost constant levels during fermentation. Diacetyl concentration in the permeate was about 2 kg⋅m-3, which is sufficiently high for commercial use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050145
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  • 6
    Electronic Resource
    Electronic Resource
    Thymoma: tumour type related to expression of epidermal growth factor (EGF), EGF-receptor, p53, v-erb B and ras p21 (1995)
    Springer
    Virchows Archiv 426 (1995), S. 43-50 
    Details
    ISSN: 1432-2307
    Keywords: Thymoma ; Epidermal growth factor-receptor ; p53 ; v-erb B ; ras p21
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As clinicopathological features may not be sufficient to predict the progression of thymoma, we have carried out what we believe to be the first immunohistochemical study describing the relationship between the different types of thymoma and the tumour stage, on the one hand, and the expression of epidermal growth factor (EGF), EGF-receptor (EGFR), p53, v-erb B and ras p21, on the other. The positive rates versus histological types and Masaoka's clinical stages in the 47 cases were as follows: p53 (non-invasive thymoma: 41.7%; malignant thymoma category I: 82.4%; malignant thymoma category II: 83.3%), EGF (non-invasive thymoma: 4.2%; malignant thymoma category I: 11.8%; malignant thymoma category II: 33.3%) and EGFR (non-invasive thymoma: 8.3%; malignant thymoma category I: 35.3%; malignant thymoma category II: 66.7%); p53 (stages I and II: 51.7%; stages III and IV: 77.8%), EGF (stages I and II: 3.4%; stages III and IV: 22.2%) and EGFR (stages I and II: 13.8%; stages III and IV: 44.4%). These data suggest that p53 may be implicated in the initial stages of tumorigenesis and that increased expression of EGF and EGFR may play a role in thymoma progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194697
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  • 7
    Electronic Resource
    Electronic Resource
    Diacetyl fermentation coupled with pervaporation using oleyl alcohol supported liquid membrane (1995)
    Springer
    Bioprocess and biosystems engineering 13 (1995), S. 119-123 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Pervaporation using oleyl alcohol supported liquid membrane was successfully applied to diacetyl fermentation by immobilized lactic acid bacteria. Diacetyl productivity was about 10 g·m−3·h−1, while productivity during batch fermentation was about 6 g·m−3·h−1. Diacetyl yield from consumed glucose was about 0.04 g·g−1 which was 4 times as large as that of batch fermentation. The pervaporation functioned favorably on actual fermentation broth. The flux of the permeate and the diacetyl separation factor for the pervaporation were about 9 g·m−2·h−1 and 36, respectively, and these values were maintained at almost constant levels during fermentation. Diacetyl concentration in the permeate was about 2 kg·m−3, which is sufficiently high for commercial use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369694
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  • 8
    Electronic Resource
    Electronic Resource
    AVP-induced mitogenic responses of Chinese hamster ovary cells expressing human V1A or V1B receptors (1999)
    Springer
    Pflügers Archiv 437 (1999), S. 219-226 
    Details
    ISSN: 1432-2013
    Keywords: Key words Arginine vasopressin ; Mitogen-activated protein kinase ; Proliferation ; V1A receptor ; V1B receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Arginine vasopressin (AVP) induces cell proliferation and hypertrophy; however, the human receptor subtype and the intracellular signaling pathways responsible for this mitogenic activity remain unclear. Experiments were conducted to determine which AVP receptor is linked to mitogen-activated protein (MAP) kinase activation and the mitogenic effect seen in Chinese hamster ovary (CHO) cells expressing human V1A or V1B receptors. Adding AVP to CHO cells transfected with human V1A or V1B cDNA significantly and concentration-dependently induced activation of MAP kinase and increased DNA synthesis, as measured by [3H]thymidine incorporation. These effects were inhibited by AVP receptor antagonists and the potency order of antagonists in vitro was similar to that observed in radioligand binding assays. These results suggest that AVP induces the MAP kinase cascade leading to cell proliferation through either human V1A or V1B receptors, and that these cloned, expressed AVP receptors may prove an invaluable tool for probing the physiologic and pathophysiologic effects of AVP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050772
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacological characterization of YM087, a potent, nonpeptide human vasopressin V1A and V2 receptor antagonist (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1997), S. 63-69 
    Details
    ISSN: 1432-1912
    Keywords: Key words Vasopressin ; Vasopressin V1A receptor ; Vasopressin V2 receptor ; Nonpeptide antagonist ; Second messenger systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of YM087 (4’-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)-carbonyl]-2-phenylbenzanilide monohydrochloride), a novel nonpeptide vasopressin (AVP) receptor antagonist, on [3H]AVP binding to human AVP receptors (V1A, V1B and V2) cloned and transiently expressed in COS-1 cells generated from monkey renal tissue were studied. Scatchard analysis of saturation isotherms for the specific binding of [3H]AVP to membranes, prepared from COS-1 cells transfected with human V1A, V1B and V2 receptors, yielded an apparent equilibrium dissociation constant (K d) of 0.67nM, 0.28nM and 2.14nM and a maximum receptor density (B max) of 2180fmol/mg protein, 369fmol/mg protein and 2660fmol/mg protein, respectively. YM087 showed high affinity for AVP V1A and V2 receptors with K i values of 6.3 and 1.1nM, respectively, but had no effect on [3H]AVP binding to AVP V1B receptors. In COS-1 cells expressing either AVP V1A or V1B receptors, AVP caused a concentration-dependent increase in intracellular Ca2+ concentration ([Ca2+]i). YM087 inhibited the AVP-induced increase in [Ca2+]i in COS-1 cells expressing AVP V1A receptors in a concentration-dependent manner with an IC50 value of 14.3nM, but did not influence this increase in AVP V1B-receptor expressing cells. In contrast, stimulation of COS-1 cells expressing AVP V2 receptors resulted in an accumulation of cAMP. YM087 inhibited AVP-induced cAMP production in COS-1 cells expressing AVP V2 receptors in a concentration-dependent manner with an IC50 value of 1.95nM. In all assays used, YM087 was devoid of any agonistic activity. These results suggest that YM087 is a potent nonpeptide dual human AVP V1A and V2 receptor antagonist, and that YM087 will be a powerful tool in investigation of the physiological and pathophysiological roles of AVP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005139
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  • 10
    Electronic Resource
    Electronic Resource
    Intermediate phase on rapidly quenched Ni49Ti50Al1 (1999)
    Springer
    Journal of materials science 18 (1999), S. 1853-1854 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006611709098
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