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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of endothelial cell adhesion molecule expression with SJC13, an azaindolidine derivative, in vitro (1996)
    Springer
    Inflammation research 45 (1996), S. 224-229 
    Details
    ISSN: 1420-908X
    Keywords: E-selectin ; Intercellular adhesion molecule-1 ; Vascular cell adhesion molecule-1 ; Vascular endothelial cells ; Azaindolidine derivative
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Stimulation of cultured human umbilical vein endothelial cells (HUVEC) with lipopolysaccharide (LPS) induces adherences for human promyelocytic cell line HL60. Adherence of HL60 cells to HUVEC stimulated with LPS for 4h was completely inhibited by pretreatment with SJC13, an azaindolidine derivative. The mechanism whereby SJC13 inhibits the adhesiveness of HUVEC was investigated. Pretreatment of SJC13 inhibited LPS-induced expression of E-selectin and vascular cell adhesion molecule-1 (VCAM-1), but not intercellular adhesion molecule-1 (ICAM-1), in HUVEC, determined by flow cytometry and cellular enzyme-linked immunosorbent assay (cell-ELISA). The inhibitory activity was concentration dependent between 62.5 and 1,000 μg/ml. SJC13 also selectively inhibited LPS-induced increases in E-selectin and VACM-1 mRNAs, indicating that the action of SJC13 is to inhibit synthesis of these molecules. These data demonstrate that SJC13 is capable of selectively inhibiting the expression of E-selectin and VCAM-1, but not ICAM-1, in endothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02259607
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  • 2
    Electronic Resource
    Electronic Resource
    Protection against septic shock in mice with SJC13, an azaindolidine derivative that is a cell adhesion molecule inhibitor (1996)
    Springer
    Inflammation research 45 (1996), S. 448-451 
    Details
    ISSN: 1420-908X
    Keywords: Septic shock ; Neutrophil ; Cell adhesion molecule inhibitor ; Azaindolidine derivative ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An azaindolidine derivative, SJC13, selectively inhibits expression and mRNA synthesis of E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVEC) stimulated with lipopolysaccharide (LPS). The present experiments were performed to determine the in vivo effects of SJC13 against the lethality of LPS. In a mouse model of septic shock, intravenous administration of SJC13 5 min prior to LPS injection prevented significantly the lethality at doses of 3 mg/kg and 10 mg/kg. The prophylactic effect was dose-dependent. When injected up to 1h after LPS injection, SJC13 inhibited significantly the lethality. Neutrophil emigration into lung tissues during sepsis induced with LPS, as assessed by lung myeloperoxidase (MPO) content and histological examination, was significantly prevented by SJC13 administration. These data demonstrate that SJC13 has therapeutic anti-inflammation potential in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252315
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  • 3
    Electronic Resource
    Electronic Resource
    Cardiopulmonary function in bicycle racing over mountainous terrain at moderate altitude (1995)
    Springer
    International journal of biometeorology 38 (1995), S. 126-130 
    Details
    ISSN: 1432-1254
    Keywords: Bicycle racing ; Cardiopulmonary function ; Moderate altitude
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract To examine cardiopulmonary function during exercise in a mountainous region at moderate altitude, we measured cardiac frequency, oxygen consumption $$\left( {\dot VO_2 } \right)$$ , and percentage arterial hemoglobin oxygen saturation (%SaO2) before and after a bicycle race with a starting point at 638 m and finishing point at 1980 m. The time required to ascend an elevation of 10 m was prolonged with increasing altitude, and heart rate also increased with altitude. The %SaO2 at the starting point and at the finishing point differed significantly (P〈0.01). Faster cyclists exhibited higher %SaO2 and lower $$\dot VO_2 $$ , while slower cyclists exhibited a reduction in %SaO2 and an increase in $$\dot VO_2 $$ immediately after the race. The %SaO2 recovery time was significantly correlated with the racing time (r=0.54,P〈0.001). Therefore, the faster cyclists' oxygen debt upon completion of the race may be small and recovery of cardiopulmonary function may be fast, while the slower cyclists' oxygen debt may be large and recovery of cardiopulmonary function may be slow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208488
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of muscle force, muscle endurance, and electromyogram activity during an expedition at high altitude (1996)
    Springer
    International journal of biometeorology 39 (1996), S. 111-115 
    Details
    ISSN: 1432-1254
    Keywords: Acclimatization ; High altitude ; Muscle power ; Muscle endurance ; EMG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Handgrip force (HF), maximal pinch force (MF), muscle endurance (ME), and the median power frequency (MdPF) of the activity shown in the electromyogram (EMG) were studied at various altitudes in eight normal healthy subjects. MF and ME were measured between the index finger and thumb, and all measurements were obtained at altitudes ranging from 610 to 4860 m during an expedition in the Qinghai Plateau in China. With the change in altitude HF, ME, and MF showed no significant change. Compared to the MdPF at 2260 m on ascent, the MdPF at other altitudes showed a significant decrease (P〈0.01). Thus, we conclude that muscle performance (HF, MF, and ME) was not affected by the environment at high altitude. However, MdPF was affected and the mean MdPF at 610 m after the expedition did not recover to initial values of MdPF. We suggest these results may have been affected by fatigue and chronic exposure to the hypobaric hypoxic environment, since the members of the expedition party expressed feelings of sluggishness and fatigue after the expedition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211221
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  • 5
    Electronic Resource
    Electronic Resource
    Lung cyclic nucleotides in exercise-trained rats attenuate hypoxic pulmonary vasoconstriction (1995)
    Springer
    Lung 173 (1995), S. 363-372 
    Details
    ISSN: 1432-1750
    Keywords: Cyclic AMP ; Cyclic GMP ; Exercise ; Exercise training ; Hypoxia ; Hypoxic pulmonary vasoconstriction ; Pulmonary arterial pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the effects of exercise training on pulmonary arterial blood pressure (Ppa) and on adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (GMP) concentrations in lung tissue at rest and during exercise under hypoxic conditions in catheter-implanted rats. Male Wistar rats were divided into an exercise-trained group (ET, n = 32) and nonexercised control group (control, n = 32). ET rats exercised 40 min/day 6 days/week for 6 weeks, at an altitude of 610 m on a treadmill. The mean Ppa levels of the ET were significantly lower than those of controls at rest and during exercise at 610- and 2500-m altitudes. The exercise-induced mean Ppa increase in the ET was less than that in controls at both 610- and 2500-m altitudes. Resting lung cAMP increased more in the ET than in controls at both 610- and 2500-m altitudes. In ET, cGMP was significantly greater at the 2500-m altitude than at the 610-m altitude at rest and just after exercise. Hypoxic exercise in ET was accompanied by a preferential increase in cGMP but not in cAMP. These results suggest that the intracellular augmentation of cAMP and cGMP in ET plays an important role in attenuating hypoxic pulmonary vasoconstriction (HPV) and exercise-induced increases in Ppa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172143
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  • 6
    Electronic Resource
    Electronic Resource
    Large-dose ascorbic acid administration suppresses the development of arthritis in adjuvant-injected rats (1999)
    Springer
    Archives of orthopaedic and trauma surgery 119 (1999), S. 121-126 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed animal experiments to test the hypothesis that active oxygen species (AOS) play a major role in adjuvant-induced arthritis in rats and to determine whether large-dose ascorbic acid administration would suppress the development of arthritis, reducing the level of damaging AOS in the same animal model. Arthritis was induced in male Lewis rats by adjuvant injection into the base of the tail. Ascorbic acid at doses of 0.5, 1.0, and 2.0 g/kg body weight (BW) was injected intraperitoneally twice each week for 3 weeks (9 rats per group). The BW, hind paw edema, and arthritis score of the extremities were monitored during the period. On day 21, synovial tissues obtained from the ankle joints were examined histologically and for the activity of superoxide dismutase (SOD). The SOD activity in the red blood cells (RBC) was also measured. The arthritic control rats showed significant increases in paw volume and arthritis score from day 11. These changes were dose-dependently reduced by ascorbic acid administration. The infiltration of inflammatory cells into the synovial tissues was markedly decreased by ascorbic acid. The increases in SOD activities produced by the adjuvant injection were significantly reduced in both the synovium and the RBC at ascorbic acid doses of 1.0 and 2.0 g/kg BW. In conclusion, large-dose ascorbic acid administration reduced the increases in hind paw inflammatory edema, arthritis in the extremities, and infiltration of the inflammatory cells into the synovial tissue in the adjuvant-induced arthritis rats. Since these anti-arthritic effects were associated with a decrease in SOD activities in both the synovium and RBC, the decrease in SOD activity could be one of the mechanisms underlying the suppressive effects of large-dose ascorbic acid on the development of arthritis in this animal model, inhibiting the damaging AOS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050374
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  • 7
    Electronic Resource
    Electronic Resource
    Congenital extension contracture of metacarpophalangeal joints (1997)
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 426-428 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of congenital extension contracture of the fifth metacarpophalangeal joints in a 15-year-old boy who had no associated anomalies and was successfully treated by surgery. Congenital extension contracture of bilateral metacarpophalangeal joints has not been reported previously, and the entity can be considered to be a new subgroup of distal arthrogryposis with congenital distal limb contracture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050154
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  • 8
    Electronic Resource
    Electronic Resource
    Congenital extension contracture of metacarpophalangeal joints (1997)
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 426-428 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of congenital extension contracture of the fifth metacarpophalangeal joints in a 15-year-old boy who had no associated anomalies and was successfully treated by surgery. Congenital extension contracture of bilateral metacarpophalangeal joints has not been reported previously, and the entity can be considered to be a new subgroup of distal arthrogryposis with congenital distal limb contracture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434006
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  • 9
    Electronic Resource
    Electronic Resource
    Painful junctura tendinum of the hand extensors (1998)
    Springer
    Archives of orthopaedic and trauma surgery 117 (1998), S. 392-393 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of painful junctura tendinum of the hand extensors is presented. This rare condition may have developed because of anatomical factors, including the type of connection and location of the junctura, and because of the unique position that the fingers assume during bowling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050275
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  • 10
    Electronic Resource
    Electronic Resource
    Cryopreservation of in vitro-grown axillary shoot-tip meristems of mint (Mentha spicata L.) by encapsulation vitrification (1999)
    Springer
    Plant cell reports 19 (1999), S. 150-155 
    Details
    ISSN: 1432-203X
    Keywords: Key words Cryopreservation ; Encapsulation-vitrification ; Meristems ; Mint ; Vitrification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Alginate-coated meristems from in vitro-grown axillary buds of mint (Mentha spicata L.) were successfully cryopreserved by vitrification. Excised meristems from nodal segments cold hardened at 4  °C for 3 weeks were encapsulated and osmoprotected by a mixture of 2 M glycerol plus 0.4 M sucrose. These meristems were dehydrated with a highly concentrated vitrification solution (PVS2 solution) for 3 h at 0  °C prior to a plunge into liquid nitrogen. Successfully encapsulated vitrified meristems developed shoots within a week after plating without intermediary callus formation. The average rate of shoot formation amounted to nearly 90%. This procedure was successfully applied to other Mentha species. It was also confirmed that encapsulated vitrified meristems produced a much higher rate of shoot formation than the encapsulated dried meristems. Thus, this revised encapsulation vitrification method appears promising for the cryopreservation of mint and other germplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050725
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