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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annales geophysicae 16 (1998), S. 787-803 
    ISSN: 0992-7689
    Keywords: Magnetospheric physics (MHD waves and instabilities; Plasma waves and instabilities; Solar windmagnetosphere interactions)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Highlights of studies of ULF waves from 1995 to early 1997 are presented. The subjects covered include (1) Pc 3–5 waves excited by sources in the solar wind, with emphasis on the role of the magnetospheric cavity in modifying the external source and establishing its own resonances, and the role of the plasmapause in magnetohydrodynamic wave propagation; (2) Pi 2 waves, with emphasis on the plasmaspheric resonances and possible alternative excitation by plasmasheet source waves; (3) the spatial structure of internally excited long-period waves, including a kinetic theory for radially confined ring current instability and groundbased multipoint observation of giant pulsations; (4) amplitude-modulated Pc 1–2 waves in the outer magnetosphere (Pc 1–2 bursts) and in the inner magnetosphere (structured Pc 1 waves or pearls); and (5) the source region of the quasi-periodic emissions. Theory and observations are compared, and controversial issues are highlighted. In addition, some future directions are suggested.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Keywords N-acetylcysteine ; glutathione ; tumour necrosis factor α ; diabetic neuropathy ; motor nerve conduction velocity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis, a free radical scavenger and an inhibitor of tumour necrosis factor α (TNF). Because these functions might be beneficial in diabetic complications, in this study we examined whether NAC inhibits peripheral neuropathy. Motor nerve conduction velocity (MNCV) was significantly decreased in streptozotocin-induced-diabetic Wistar rats compared to control rats. Oral administration of NAC reduced the decline of MNCV in diabetic rats. Structural analysis of the sural nerve disclosed significant reduction of fibres undergoing myelin wrinkling and inhibition of myelinated fibre atrophy in NAC-treated diabetic rats. NAC treatment had no effect on blood glucose levels or on the nerve glucose, sorbitol and cAMP contents, whereas it corrected the decreased GSH levels in erythrocytes, the increased lipid peroxide levels in plasma and the increased lipopolysaccharide-induced TNF activity in sera of diabetic rats. Thus, NAC inhibited the development of functional and structural abnormalities of the peripheral nerve in streptozotocin-induced diabetic rats. [Diabetologia (1996) 39: 263–269]
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: N-acetylcysteine ; glutathione ; tumour necrosis factor α ; diabetic neuropathy ; motor nerve conduction velocity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis, a free radical scavenger and an inhibitor of tumour necrosis factor α (TNF). Because these functions might be beneficial in diabetic complications, in this study we examined whether NAC inhibits peripheral neuropathy. Motor nerve conduction velocity (MNCV) was significantly decreased in streptozotocin-induced-diabetic Wistar rats compared to control rats. Oral administration of NAC reduced the decline of MNCV in diabetic rats. Structural analysis of the sural nerve disclosed significant reduction of fibres undergoing myelin wrinkling and inhibition of myelinated fibre atrophy in NAC-treated diabetic rats. NAC treatment had no effect on blood glucose levels or on the nerve glucose, sorbitol and cAMP contents, whereas it corrected the decreased GSH levels in erythrocytes, the increased lipid peroxide levels in plasma and the increased lipopolysaccharide-induced TNF activity in sera of diabetic rats. Thus, NAC inhibited the development of functional and structural abnormalities of the peripheral nerve in streptozotocin-induced diabetic rats.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Keywords Troglitazone ; diabetic neuropathy ; free radical scavenger ; tumour necrosis factor-α (TNF-α) ; motor nerve conduction velocity (MNCV).
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Free-radical scavengers and inhibitors of tumour necrosis factor-α (TNF-α) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazolidinedione, on diabetic neuropathy, since it also is a free-radical scavenger and a TNF-α inhibitor. Rats were fed powder chow mixed with troglitazone at 0.5 % and 0.125 % ad libitum. Although blood glucose concentrations were remarkably higher and body weight lower in diabetic than in nondiabetic rats, troglitazone had no effect on these throughout the 24-week experiment. Serum lipoperoxide concentrations, tibial nerve lipoperoxide content and serum TNF-α activity induced by lipopolysaccharide was increased in diabetic rats, but inhibited in troglitazone-treated rats. Motor nerve conduction velocity (MNCV) of the tibial nerve slowed in diabetic rats, compared with that in nondiabetic rats. On the other hand, the slowed MNCV was (p 〈 0.05–0.01) inhibited after weeks 12 and 16 of the experiment in diabetic rats treated with high and low doses of troglitazone, respectively. Morphometric analysis showed that troglitazone suppressed the decrease of the myelinated fibre area (p 〈 0.05), axon/myelin ratio (p 〈 0.01) and fascicular area (p 〈 0.05) and suppressed the increase of myelinated fibre density (p 〈 0.001) in diabetic rats. These results indicate that troglitazone has a beneficial effect on peripheral neuropathy in STZ-induced diabetic rats irrespective of blood glucose concentrations. [Diabetologia (1998) 41: 1321–1326]
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0509
    Keywords: Key words: Dissection—Superior mesenteric artery—3DCT—Color Doppler.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A case of an isolated dissecting aneurysm of the superior mesenteric artey is presented with findings of three-dimensional CT imaging. False lumen, intimal flap, entry, and re-entry are clearly identified on threedimensional CT imaging.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1890
    Keywords: Key words Arbuscular mycorrhizal fungi ; Carbon origin ; δ13C ; C3 plant ; C4 plant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The origin of carbon in the spores of arbuscular mycorrhizal (AM) fungi was quantified based on their obligate symbiosis with C3 and C4 plants showing clearly different δ13C values. The δ13C values of individual spores of the AM fungus Gigaspora margarita were analyzed. In monoculture pots of a C3 or a C4 plant species, spore δ13C values were ca. 3.5‰ lower than those of host roots. In coculture pots of a C3 and a C4 plant species, spore δ13C values varied between those of the roots of C3 and C4 plants, and increased linearly from the C3 to the proximity of the C4 plant (P〈0.01). This reflects the higher δ13C values in C4 plants than in C3 plants. Thus the carbon origin of G. margarita spores changed with growth state and combination of host plants. In the presence of fresh plant residue instead of living host plants, spore δ13C values did not vary with distance from the residue. This finding supports the current view that AM fungi are obligate symbionts.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1432
    Keywords: Key words: Evolutionary motif — Motif length — Multiple alignment — Window analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execution, until the relationships and alignment results are in agreement. We then applied this method to the data of the international DNA sequence databases, which are the most comprehensive and updated DNA databases in the world, in order to estimate the ``evolutionary motif'' by extensive use of a supercomputer. Though a few problems needed to be solved, we could estimate the length of the motifs in the range of 20 to 200 amino acids, with about 60 the most frequent length. We then discussed their biological and structural significance. We believe that we are now in a position to analyze DNA and protein not only in vivo and in vitro but also in silico.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The role of the conserved sequence region III in the promoter regions of the amylase-encoding genes amyB, glaA and agdA of Aspergillus oryzae was examined. Introduction of multiple copies of the region III fragment into the agdA promoter resulted in a significant increase in promoter activity at the transcriptional level. This result suggests that the fragment comprising region III consists of one or more cis-acting sequence(s). Moreover, expression of the agdA gene under the control of the improved agdA promoter resulted in efficient overproduction of α -glucosidase, even in the presence of glucose. Thus, overexpression of genes controlled by the improved promoter incorporating region III is possible. Interestingly, expression of the amyB and glaA genes in the transformant was strongly repressed. This result suggests that the trans-acting regulatory protein(s) that interact with region III are common to these amylase genes and that the titration of regulatory protein(s) reduced the expression of the amyB and glaA genes.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0630
    Keywords: PACS: 61.46.tw; 81.05.Tp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Laser ablation of graphite in an Ar atmosphere at 560 Torr was done using a nanosecond-pulse Nd:YAG laser (1064 nm) at a fluence of 12 J/cm2. Dynamics in the ejection of carbon species and in their confinement near the graphite surface (〈1 mm) due to their numerous collisions with Ar atoms were investigated by shadowgraphy, emission imaging, and emission spectroscopy at delay times of 0.01–100 μs following the laser irradiation. A shock wave was generated, and temporally and spatially dependent emissions from Ar+ and Ar were observed in addition to those from carbon species (C, C+, and C2) and the Bremsstrahlung radiation from a hot plasma. We suggest that the dissipation of the kinetic and thermal energies of the carbon species, their backward motion, and their collisions with each other lead to the formation of clusters and particles through the interaction with Ar atoms.
    Type of Medium: Electronic Resource
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