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  • 1
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Marine biology 126 (1996), S. 655-661 
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract During the summer of 1995, we investigated the response of mud crab megalopae (Panopeus herbstii Milne-Edwards) to cues associated with adult habitat. Natural rock/shell substratum and the rock-associated seaweed, Fucus vesiculosus L., both induced metamorphosis of competent megalopae; natural sand substratum did not induce metamorphosis. Structural mimics of preferred substrata induced metamorphosis only when covered with natural biofilm. Clean mimics did not induce metamorphosis. Water-soluble exudates from preferred substrata showed weak induction of metamorphosis. Exudates from adult P. herbstii elicited a similar weak response. Exudates from another species of crab and from two fish predators did not induce metamorphosis. We conclude that water-soluble cues associated with major components of preferred adult habitat induce the metamorphic molt of P. herbstii megalopae. The three-dimensional structure of the substratum is not important in induction of metamorphosis, but the biofilm associated with preferred substratum plays a critical role. It is not clear whether the biofilm produces the water-soluble cue or simply provides a tactile stimulus that works in conjunction with the soluble cue.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 72 (1994), S. 409-413 
    ISSN: 1432-1440
    Keywords: Myotonic dystrophy ; Limb girdle muscular dystrophy ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A family is reported in which a 29-year-old woman showed the clinical features of myotonic dystrophy while her 26-year-old brother presented with the clinical picture of limb girdle syndrome. In the affected female, direct genetic testing for the specific myotonic dystrophy mutation on chromosome 19 revealed abnormal expansion of a repeat unit containing the three nucleotides cytosine, thymine, and guanine (CTG) — typical for myotonic dystrophy — while her diseased brother displayed two normal alleles. This supports the hypothesis of the extremely rare occurrence of two clinically and genetically different myopathies in one family. Genetic analysis of six other family members showed that the father of the diseased siblings as well as all of his three brothers and sisters had a pathological CTG repeat expansion, and that the other two family members tested had a normal allelic pattern. The number of CTG repeats in the diseased women was approximately tenfold higher than in her asymptomatic relatives who revealed an abnormal allelic pattern. The increase in CTG repeats with transmission to a subsequent generation in this family was paralleled by a dramatic increase in the severity of myotonic dystrophy.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The identification of the molecular defect in a significant proportion of cystic fibrosis families (in our series up to 60%) allows direct DNA diagnosis.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 2 (1992), S. 292-298 
    ISSN: 1432-1084
    Keywords: Spine surgery ; Automated percutaneous discectomy ; Lumbar disc herniation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From July 1989 to June 1991 135 discs on 129 patients were treated, in about twothirds at level L4/5 and at the remaining one third L5/S1.15% (n = 2) failed technically. Sixty eight patients are in the 1-year follow-up. Average age was 41 years (range 16–68 years). Average pain duration was 12 months, and average aspiration time was 25.8 min (range 15–45 min). All patients had contained disc lesions, suffered from radicular symptoms and had not responded to conservative treatment. 67,1% (group A, n =45) had a failure rate of 17,8%. Patients with associated degenerations (group B, n = 7) had a failure rate of 35,3%. 80% of the patients with recurrent radicular symptoms (group C, interval patients, n = 6) were free of symptoms. Re herniation rate in all patients was 2.9%, and the laminectomy rate 4.4%. No major complications were noted. Treated disc level, patient aage, aspirated nucleus material and CT changes revealed no correlation to clinical success. Patients with associated degenerations (group B) as wellas those with longer pain duration and larger contained disc lesions had a significantly worse outcome.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 703-704 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0942-0940
    Keywords: Middle cerebral artery occlusion ; cerebral blood flow ; ischaemia ; reperfusion ; laser Doppler flowmetry ; hydrogen clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monitoring cerebral blood flow during focal ischaemia and reperfusion with established techniques such as hydrogen clearance and autoradiography is difficult. Laser Doppler flowmetry is a new technique, it allows one to continuously measure blood flow in small tissue samples. The objective of this study was to compare laser Doppler flowmetry with hydrogen clearance using a new single fiber probe to obtain measurements in deep brain structures and then to show the temporal profile of cerebral blood flow during focal ischaemia and after reperfusion. First, the single fiber laser Doppler method was compared with the hydrogen clearance method in ten Wistar rats. Second, focal cerebral ischaemia was induced in fifteen Wistar rats using a model of middle cerebral artery occlusion based on the intravascular insertion of a nylon suture; reperfusion occurred after withdrawal of the suture. The laser Doppler probe was placed in the lateral caudatoputamen, and local cerebral blood flow was measured continuously before and during occlusion as well as after reperfusion. The relative blood flow values obtained by the laser Doppler method and the hydrogen clearance method showed a good correlation (r=0.76) and a linear relationship. A rapid decrease in laser Doppler flowmetry to 42±16% of former baseline values was seen with occlusion of the middle cerebral artery; during occlusion cerebral blood flow remained at this level. Reperfusion resulted in a heterogeneous pattern of cerebral blood flow as laser Doppler flowmetry values ranged from 25% to 134% of baseline values. The effects of middle cerebral artery occlusion and reperfusion on cerebral blood flow can be monitored on-line with laser Doppler flowmetry. Our findings suggest that this method, with the high spatial and temporal resolution characteristics of its new single fiber probe, allows one to continuously measure microcirculatory blood flow in deep brain structures.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 141 (1999), S. 219-220 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 274-280 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The structure of the ground and lowest two excited states of H2NO have been determined in large scale configuration interaction calculations using a multiconfiguration self-consistent description of the molecular orbitals. These treatments are based on a systematic building of the correlation contribution which has been designed to account for the characteristics of the nitroxide group. This approach shows that the aminoxyl functional group is more than a three electron group shared by two atoms, but, in fact, a nine electron entity. Our best estimate of the geometry of the ground electronic state, obtained after second-order configuration interaction using a large basis of atomic natural orbitals, is pyramidal. However, since the potential depth between 0° and 40° is lower or of the same order of magnitude as the estimated inversion frequency, the conclusion that this molecule behaves like a planar system is totally justified. The structure of the excited (n−π*) and (π−π*) states have been determined and the transitions energies are in accordance with the experimental results on the highly substituted stable nitroxide radicals. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 6943-6946 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The photoluminescence spectra of crystalline silicon samples are measured for temperatures below 1000 K. The optical transitions are analyzed in terms of excitonic and band-to-band transitions. From the modeling of the line shape we are able to determine the fundamental indirect band gap for temperatures up to 750 K. The temperature dependence follows the Varshni equation with Eg(0)=1.1692 eV, α=(4.9±0.2)×10−4 eV/K and β=(655±40) K. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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