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  • 1
    Electronic Resource
    Electronic Resource
    Ätiologie und Pathogenese (1937)
    Springer
    Journal of cancer research and clinical oncology 45 (1937), S. 92-98 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01619039
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  • 2
    Electronic Resource
    Electronic Resource
    Infektion (1937)
    Springer
    Journal of cancer research and clinical oncology 45 (1937), S. 188-195 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01638952
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acute-phase protein detection and quantification in gingival crevicular fluid by direct and indirect immunodot (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 18 (1991), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The development of an assay for markers of active periodontitis, obtained directly from gingival crevicular fluid (GCF) and simply quantified, would be of great importance to the dental practitioner. The purpose of this study was to evaluate direct and indirect immunodot techniques as to their potential in easily quantifying acute-phase proteins within periodontally diseased and healthy site GCF. Indirect immunodots (GCF eluates dotted onto nitrocellulose membrane) using monoclonal antibodies and a radioactive isotope label were used to identify and establish relative amounts of C-reactive protein (CRP) and alpha-2-macroglobulin (A2M) in 2 diseased and 2 healthy sites in 24 periodontitis patients. Periodontally diseased sites were found to contain significantly lower concentrations of A2M than healthy sites (p 〈 0.001), but CRP levels did not vary significantly between healthy and diseased locations. Using a direct immunodot assay (GCF absorbed directly into nitrocellulose membrane strips), A2M levels quantified with radioactive isotopes at healthy and diseased sites could be correlated with A2M levels determined by enzyme-linked antibody-colormetric probes at those same sites. Such a direct sampling and quantification system shows promise for future “in-office” diagnostic methodology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1991.tb01697.x
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  • 4
    Electronic Resource
    Electronic Resource
    Prostaglandin E2 and interleukin-1 levels in smokeless tobacco-induced oral mucosal lesions (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 29 (1994), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Inflammatory mediators released as a result of smokeless tobacco (ST)-induced irritation may play a role in the development of oral mucosal lesions at habitual tobacco placement sites in ST users. The present study examined levels of interleukin-1 (IL-1) and prostaglandin E2 (PGE2) in ST-induced mucosal lesions and compared these to mediator levels in clinically normal mucosa. Soft tissue biopsies were obtained from white mucosal lesions at habitual placement sites and normal alveolar mucosal tissue at non-placement sites in 18 ST users. Fifteen non-tobacco using subjects also provided normal alveolar mucosal biopsies. IL-1 and PGE2 were recovered from the specimens, and mediator levels were determined by enzyme immunoassay. Prostaglandin E2 levels (pg/mg) were lower in both regions in the ST subjects, but values did not vary significantly between the regions with 2.77±0.72 and 2.86±0.99 at placement and non-placement sites, respectively, in ST users and 7.31±3.84 in non-tobacco users. Both IL-1α and IL-lβ (pg/mg) were significantly (p 〈 0.0I) elevated in ST lesions (IL-lã=25.56±4.00; IL-1β=7.76±1.68) compared to either non-placement sites in ST users (IL-lα=14.64±2.65; IL-lβ=1.63±0.72) or non-tobacco users (IL-lα=12.84±2.60; IL-lβ=2.04±0.75). In view of IL-l's role in keratinocyte proliferation and its inflammatory effects, this cytokine may contribute to mucosal and gingival alterations observed in ST users.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1994.tb01245.x
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  • 5
    Electronic Resource
    Electronic Resource
    Histological evaluation of interleukin-1β and collagen in gingival tissue from untreated adult periodontitis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 29 (1994), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin-1 beta (IL-1β) may be related to the pathological processes associated with periodontitis, primarily due to its ability to induce collagenase, increase neutrophil chemotaxis, and stimulate bone resorption. This study was designed to histologically quantitate IL-1β positive cells from various histologic fields in untreated gingivitis/early periodontitis (G/EP) versus moderate /severe periodontitis (M/SP) gingival tissues, and associate these with collagen loss. Two gingival biopsies from 8 patients were collected, one from a G/EP site and one from a M/SP site. Mouse monoclonal antibodies in combination with an avidin-biotin-peroxidase system were used to stain for IL-1β, while the van Gieson method was used to stain for collagen in serial sections. Collagen loss in G/EP (35%) and M/SP (52%) fields was consistent with gingivitis and periodontitis, respectively. IL-1β positive cells in combined coronal/sulcular (Co/Su) and apical/sulcular (Ap/Su) fields (nearest the bacterial insult) were significantly more numerous compared to combined coronal/middle (Co/Mi) and apical/middle (Ap/Mi) fields (p 〈 0.05). While numbers and percentages of IL-1β positive cells were generally higher in M/SP biopsies, differences were not significant. Further, there was no correlation between the number of IL-1β positive cells and percent collagen loss. However, a significant correlation between IL-1β positive cells and corresponding gingival crevicular fluid IL-1β concentrations was noted (r = 0.65, p = 0.01). Through the use of immunohisto-chemistry, this study demonstrated that the presence of IL-lβ+ cells does not appear to have a direct association with collagen loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1994.tb01091.x
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  • 6
    Electronic Resource
    Electronic Resource
    Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent studies of the cellular mechanisms involved in chronic inflammatory periodontal disease (CIPD) have contributed significantly to our understanding of the pathogenesis of the disease process. Functional studies have demonstrated polymorphonuclear neutrophil (PMN) chemotactic defects in some 70% of subjects with localized juvenile periodontitis while chemiluminescence data have suggested that periphertal blood PMNs from young subjects with adult periodontitis (AP) may be in a metabolically active state. Further studies have shown that stimulation of PMNs with a number of periodontopathic bacteria resulted in the production of an IL-1 inhibitor suggesting a possible regulatory role for PMNs in CIPD in addition to their established protective role. Most work on the immunoregulation of CIPD has, however, concentrated on T-cells. Recent limit dilution analysis has demonstrated the presence of periodontopathic bacteria-specific T cells in peripheral blood and the involvement and homing of these cells to the local lesions of CIPD is currently the focus of many studies. In animal studies, Actinobacillus actinomycetemcomitans (Aa)-specific T-cell clones home to the gingival tissues where they may exert a protective role. Homing and retention of lymphocytes to and in specific sites is dependent upon the expression of adhesion molecules. Recent data indicate however, that while there are increasing levels of ICAM-1, LECAM-1 and PECAM-1 expression with increasing degrees of inflammation, there are no differences between gingivitis and periodontitis lesions. Cytokine profiles may be related to the role of T-cell clones homing to the gingiva in CIPD. In subjects susceptible to periodontal breakdown there may be an increase in the type 2 IL-4 producing T-cells whereas in non-susceptible subjects, type 1 IL-2/IFN-γ producing T-cells may preferentially home to the gingiva. This hypothesis is generally supported by recent data obtained from human studies but data obtained from animal studies is only partly supportive and may suggest the opposite. Nevertheless, it is now possible to construct a testable framework or model of CIPD based on these cellular and molecular mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1993.tb02108.x
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  • 7
    Electronic Resource
    Electronic Resource
    Enantiomer separation of side-chain fluorinated alkylbenzenes by capillary gas chromatography on cyclodextrin phases (1994)
    Springer
    Chromatographia 39 (1994), S. 192-199 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Enantiomer separation ; Permethylated cyclodextrin stationary phases ; Side-chain fluorinated alkylbenzenes ; Thermodynamic data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The separation of racemic side-chain fluorinated alkylbenzenes and bromofluorinated analogues by capillary gas chromatography using permethylated α, β and γ-cyclodextrins dissolved in polysiloxanes of different polarity as stationary phases is described. The influence of the achiral polysiloxane matrices on the separation of enantiomers is discussed in the light of the results obtained with the different phases. For a part of the tested compounds thermodynamic data are determined which describe the interaction of enantiomers with the stationary phase. The mechanism of separation is discussed on this basis and by comparison with data for structurally similar compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274500
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  • 8
    Electronic Resource
    Electronic Resource
    Band structures in73Se (1991)
    Springer
    The European physical journal 340 (1991), S. 141-153 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Re ; 23.30.Lv ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Excited states of73Se have been investigated up to spin, 21/2 using techniques of in-beamγ-ray spectroscopy in connection with the70Ge(α, n) reaction. Mean lifetimes of 12 levels have been determined applying Doppler-shift andγ-RF-methods. Five different bands have been identified that reflect a variety of different excitation modes. The decoupled 9/2+ band is likely to correspond to an oblate deformation while the 5/2+ band is interpreted as a strongly coupled prolate band built on the Nilsson configuration [422] 5/2+. The 3/2− band is a strongly coupled band built on the [301] 3/2} configuration.Nuclear reactions:70Ge(α,n),E=14, 16, 18, 19, 20MeV; measuredE γ,I γ,σ(E γ,θ),γγ-coin, linear polarization, DSA,γ(t).75Se deduced levels,I, π, τ, δ(E2/M1), B(σλ). Enriched targets, Ge detectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01303825
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  • 9
    Electronic Resource
    Electronic Resource
    73 Se investigated by the (α, nγ) reaction (1990)
    Springer
    The European physical journal 336 (1990), S. 241-242 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.Re ; 23.20.Lv ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The70Ge(α,nγ)73Se reaction was used to populate medium spin states of the73Se nucleus. Spins and parities up to about Iπ=(21/2+)ħ were determined by gamma angular distribution, gamma linear polarization and excitation function measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01290628
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  • 10
    Electronic Resource
    Electronic Resource
    Evidence for a two-phonon octupole vibrational state in208Pb (1992)
    Springer
    The European physical journal 341 (1992), S. 137-144 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.-k ; 27.80.+w
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Collective properties of206,208Pb have been investigated with gamma-ray spectroscopy using nuclear and electromagnetic excitation by208Pb projectiles. From the measurement of particle-particle-γ and particle-particle-γ γ coincidences a new energy level in208Pb at 5.683 MeV was observed and the data suggest an interpretation as a 2-phonon octupole vibrational state with spin 4+ or 6+. For this state one finds the same dynamical deformation parameterβ 3 as for the first-excited collective 3− state. The results are compared to predictions of models which consider, in particular, the aspects of the quadrupole interaction and the interaction of the 2-particle pairing vibration with the 2-phonon octupole vibration. For the206Pb+208Pb system at 6.2 MeV/u the nuclear potential could be determined from the measured inelastic cross sections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298473
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