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  • 1
    Electronic Resource
    Electronic Resource
    Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 418-423 
    Details
    ISSN: 1432-0533
    Keywords: Fibroblast growth factor (FGF) ; Basic FGF ; Angiogenesis ; Brain tumors ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibroblast growth factor (FGF) is a potent angiogenic factor and a mitogen for a variety of mesoderm-and neuroectoderm-derived cell types (e.g., fibroblasts, endothelial cells, astrocytes, oligodendrocytes). After application of a monospecific polyclonal antiserum, we localized basic FGF on frozen sections of 73 human brain tumors using immunohisto-chemistry. FGF was present in a variable number of tumor cells (16/16 astrocytomas, 5/5 ependymomas, 0/3 benign and 4/7 anaplastic oligodendrogliomas, 11/12 glioblastomas, 11/11 meningiomas, 6/6 neurilemmomas, 0/3 pituitary adenomas, 2/2 choroid plexus papillomas, 0/1 neurocytoma, 2/2 benign fibrous histiocytomas, 2/5 metastatic carcinomas). FGF was detected in vascular cells of 59 tumors and in fibroblasts of connective tissue stroma from all papillomas and metastases. These results tend to indicate FGF involvement in the malignant progression of gliomas due to an autocrine or paracrine action. Histopathological aspects of malignant gliomas (e.g., pseudopalisading or pathological vessels) could be related to FGF activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308718
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between photoinhibition of photosynthesis, D1 protein turnover and chloroplast structure: effects of protein synthesis inhibitors (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 17 (1994), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Irradiation of Spinach oleracea intact leaf tissue and of mesophyll protoplasts of Valerianella locusta at 20° C with strong light resulted in severe (40–80%) inhibition of photosynthesis, measured as photosystem II electron transport activity in isolated thylakoids or as fluorescence parameter FV/FM on intact leaf disks. No net degradation of the D1 protein of photosystem II was seen under these conditions. However, in the presence of streptomycin, an inhibitor of chloroplast protein synthesis, net D1 degradation (up to about 80%) did occur with a half-time of 4–6h, and photoinhibition was enhanced. Thylakoid ultrastructure remained stable during photoinhibition, even when substantial degradation of D1 took place in the presence of streptomycin. When leaf disks were irradiated at 2°C, streptomycin did not influence the degree of photoinhibition, and net Dl degradation did not occur. These results suggest that in excess (photoinhibitory) light at 20°C, turnover (coordinated degradation and synthesis) of D1 diminished the degree of photoinhibition. The observed photoinhibition is thought to be due to the accumulation of inactive photosystem II reaction centres still containing D1. In the presence of streptomycin, the Dl protein was degraded (probably in the previously inactivated centres), but restoration of active centres via D1 synthesis was blocked, leading to more severe photoinhibition. Low temperature (2°C), by restricting both degradation and resynthesis of D1, favoured the accumulation of inactive centres. Streptomycin and chloramphenicol (another inhibitor of chloroplast protein synthesis) were tested for side-effects on photosynthesis. Strong inhibitory effects of chloramphenicol, but much less severe effects of streptomycin were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.1994.tb00265.x
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  • 3
    Electronic Resource
    Electronic Resource
    A novel inorganic/organic macrocycle involving a binuclear ZnII complex of tetra(2'-pyridyl)pyrazine (TPPZ): bis[Zn2(μ-TPPZ)H2OCl(μ-ZnCl4)(μ-ZnCl2)(μ-ZnCl3H2O)] (1994)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 1461-1464 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270194000569
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  • 4
    Electronic Resource
    Electronic Resource
    Die zeitgleiche Sekretion von Prolaktin und LH-Pulsen bei hyperandrogenämischen Frauen (1993)
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 258-259 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265981
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  • 5
    Electronic Resource
    Electronic Resource
    G-CSF zur Dosisintensivierung in der Primärtherapie des fortgeschrittenen Ovarialkarzinoms (1993)
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 1061-1062 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Schlußfolgerung Eine Kombination von CBDCA/CTX und G-CSF in der Behandlung fortgeschrittener Ovarialkarzinome ist möglich. Durch die Zugabe von G-CSF verändert sich das nichthaematologische Toxizitätsspektrum nur unwesentlich. An zusätzlicher Toxizität traten mäßig starke Knochen-/Glenkschmerzen bei etwa 1/4 der Behandlungskurse auf. Die dosislimitierte Toxizität der Kombinationstherapie aus CGDCA/CTX ist die Thrombopenie. Diese wird im Gegensatz zur Granulozytopenie durch die Gabe von G-CSF nicht beeinflußt. Eine Steigerung der DI durch Intervallverkürzung scheint daher über das 21tägige Intervall hinaus mit der von uns geprüften Kombination nicht realisierbar zu sein. Mit dem vorgestellten Protokoll läßt sich eine Steigerung der DI lediglich um 20% gegenüber der Standardtherapie erreichen. mit dieser nur geringen Steigerungsrate ist eine relevante Verbesserung der Therapieergebnisse nicht zu erwarten. In einer neuen Studie mit Carboplatin als Monotherapie überprüfen wir derzeit die Möglichkeit, die CBDCA Dosisintensität um 70% unter Beibehaltung des 21tägigen Intervalls sowie einer G-CSF-Gabe Tag 10–20 zu steigern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02266307
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