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  • 1
    Electronic Resource
    Electronic Resource
    White matter lesions in psychiatric patients: a retrospective MRI study (1992)
    Springer
    European radiology 2 (1992), S. 244-246 
    Details
    ISSN: 1432-1084
    Keywords: MRI ; Psychiatry ; white matter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract T2-weighted MRI scans of psychiatric patients with at least one white matter lesion (WML) were compared to 83 non-psychiatric controls with respect to WML number and distribution. MANOVA results in significant effects for sex, age and patient group with respect to WML number. In the psychiatric patients, infratentorial WML prevailed in organic psychoses. WML number was positively correlated with age with the exception of rith temporal lobe WML. Based on WML spatial distribution, four patient clusters were found. Clusters with widely distributed WML comprised older patients with late onset of illness; right frontal and temporal WML were associated with mania, euphoria and unstable mood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00595838
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  • 2
    Electronic Resource
    Electronic Resource
    Sex hormone binding and peritumoural oedema in meningiomas: Is there a correlation? (1992)
    Springer
    Acta neurochirurgica 115 (1992), S. 98-102 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral oedema ; meningioma ; progesterone receptor ; steroid receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Steroid receptor binding activity was evaluated in specimens of 28 human cerebral meningiomas using a dextran coated charcoal (DCC) assay. Oestrogen receptor (ER) binding activity at significant levels (〉 10 fmol/mg protein) could be detected only in three postmenopausal females (11% positive cases) at low levels. Positive progesterone receptor (PR) binding was detected in eighteen of the twenty-eight analysed meningioma tissues (64% positive cases). A significantly higher level of PR in male than in female patients could be demonstrated. The degree of peritumoural oedema could be evaluated from CT scans. There was no significant correlation between lack and amount of peritumoural oedema and quantity of cytosolic PR binding activity. Therefore we conclude, that peritumoural oedema is related to other factors and a possible role of PR activity in development of peritumoural oedema and growth control of meningiomas could not be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406365
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  • 3
    Electronic Resource
    Electronic Resource
    Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: Report of two patients (1991)
    Springer
    Virchows Archiv 418 (1991), S. 179-183 
    Details
    ISSN: 1432-2307
    Keywords: Solid-cystic tumour ; Pancreas ; Hormone dependence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Solid-cystic (papillary-cystic) tumours (SCT) of the pancreas are distinctive neoplasms with a predilection for young female patients. This is the first detailed report describing the occurrence of SCT in two young male patients. Except for the extrapancreatic occurrence of one of the tumours (in the retroperitoneal region behind the head of the pancreas), all other clinicopathological features were identical to those characterizing the SCT in women. Immunostaining was (at least focally) positive for Lu 5 (broad spectrum keratin marker), vimentin and alpha-1-antitrypsin. The tumours were negative for neuroendocrine markers (except for neuron-specific enolase), pancreatic hormones and enzymes, pancreatic stone protein, carcinoembryonic antigen, CA 19-9 and nuclear oestrogen and progesterone receptors. This report does not support the suggested female sex hormone dependence of SCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600295
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  • 4
    Electronic Resource
    Electronic Resource
    Unspecific white matter lesions: prevalence, number and distribution in cranial MRI (1992)
    Springer
    European radiology 2 (1992), S. 154-158 
    Details
    ISSN: 1432-1084
    Keywords: White matter lesions ; Cerebrovascular disease ; Magnetic resonance imaging ; Brain infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To establish data about prevalence, number and topography of “unspecific” white matter lesions as seen on MRI, the T2-weighted MRI scans of 83 patients with hyperintense focal white matter changes were reviewed. Patients with known inflammatory central nervous system disease were excluded. There was an approximately linear increase in prevalence and number of lesions with age. Prevalence ranged from 18% in the third decade to over 90% in those over 70 years. We found a close correlation with concomitant periventricular hyperintensity. However, rating of Virchow-Robin spaces did not correlate with the number of white matter lesions. Both hemispheres were involved nearly equally with a minimal non-significant right side preponderance. Lesions showed a strong predilection for the frontal and parietal paraventricular “watershed” areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171404
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  • 5
    Electronic Resource
    Electronic Resource
    Neurological long-term follow-up in left atrial myxoma: Are late complications frequent or rare? (1992)
    Springer
    Journal of neurology 239 (1992), S. 170-174 
    Details
    ISSN: 1432-1459
    Keywords: Atrial myxoma ; Neurological deficits ; Stroke ; Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological manifestations were analysed in 13 patients with left atrial myxoma confirmed by histological study. In this group, 6 patients had neurological complaints at initial presentation, 5 had cardiac symptoms, and 4 patients presented with signs of systemic disease. CT was performed in 10 and MRI in 7 patients. There were signs of ischaemic or haemorrhagic infarction (6 of 12) and one lesion suggestive of myxoma metastasis; other findings mainly comprised non-specific white matter lesions revealed by MRI. Neurological follow-up 0.5–8 years after tumour resection revealed no delayed neurological complications, follow-up CT and MRI findings were not suggestive of lesions acquired after operation. It is suggested that this rare condition of cardiac myxoma should be suspected in young patients with CNS symptoms or signs lacking cerebrovascular or cardiovascular risk factors and should be included in the differential diagnosis of vasculitis. With timely diagnosis and resection of the cardiac tumour the long-term prognosis can be considered improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00833920
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  • 6
    Electronic Resource
    Electronic Resource
    Do arachnoid cysts grow? (1991)
    Springer
    Neuroradiology 33 (1991), S. 341-345 
    Details
    ISSN: 1432-1920
    Keywords: Arachnoid cysts ; Volume measured ; Cyst growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The volumes of intracranial arachnoit cysts were measured in 136 CT scans of 86 patients. Absolute and relative cyst size was calculated. Left hemisphere and middle cranial fossa location prevailed. A slight negative correlation of relative cyst size with age (r=−0.21, NS) disappeared when analysis was restricted to the adult age group (≥20 years). After the sample was divided into two groups according to relative cyst size (cysts less than mean volume vs cysts greater than mean volume), small AC showed no correlation with age, while large AC correlated positively with age (r=0.79,P〈0.05). A subgroup of large AC appears to expand with time, while the majority of small AC remain unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587820
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  • 7
    Electronic Resource
    Electronic Resource
    Reliability of transcranial colour-coded real-time sonography in assessment of brain tumours: correlation of ultrasound, computed tomography and biopsy findings (1994)
    Springer
    Neuroradiology 36 (1994), S. 585-590 
    Details
    ISSN: 1432-1920
    Keywords: Brain tumours ; Ultrasonography ; Computed tomography ; Stereotactic biopsy ; Transcranial colour-coded real time sonography ; Glloma ; Central nervous system ; Duplex sonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transcranial colour-coded real-time sonography (TCCS) was carried out in 25 patients with brain tumours to determine whether this noninvasive method provides additional information about the extent of solid tumour, its differentiation from oedema, and its tissue components. All 25 patients had serial computed tomography (CT)-guided stereotactic biopsies. Comparison of ultrasound, CT and histological findings revealed that the vast majority of contrast enhancing areas on CT were hyperechogenic (32/33; 97%) and contained tumour tissue (29/32; 91%). Hyperechogenic areas always represented solid tumour (23/23 patients), even when CT showed low density non-enhancing lesions. In lestons hypoechogenic on TCCS and low density on CT, histology consistently revealed necrotic tumour (7/7). Biopsies obtained from parenchyma with normal echogenicity revealed tumour in only 3 of 16 speciemens. Despite the high specificity of TCCS in the differentiation of tumour components, its sensitivity to tumour was inferior to that of CT (24/25; 96%). TCCS thus allows noninvasive preoperative identification of tumour tissue and its extent setting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600414
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  • 8
    Electronic Resource
    Electronic Resource
    Cranial MRI and CT in patients with left atrial myxoma (1992)
    Springer
    Neuroradiology 34 (1992), S. 57-61 
    Details
    ISSN: 1432-1920
    Keywords: Cardiac myxoma ; Stroke ; Cerebrovascular disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six of 12 patients with histologically verified left atrial myxoma showed CT and MRI evidence of ischemic lesions of varying size and location, predominantly in the left hemisphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588434
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  • 9
    Electronic Resource
    Electronic Resource
    The “dense artery sign” — major cerebral artery thromboembolism demonstrated by computed tomography (1990)
    Springer
    Neuroradiology 32 (1990), S. 98-103 
    Details
    ISSN: 1432-1920
    Keywords: Cerebral infarction ; Thrombembolism ; Computed tomography ; Density quantification ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 4 years review of high resolution thin slice (3–5 mm) computed tomography performed within 24 h after cerebral infarction revealed increased density in a major cerebral artery segment in 28 patients. Arteries affected were the vertebral and basilar artery in 6 and 8 patients, the sphenoid course of the middle cerebral artery in 13 cases and the extracranial internal carotid artery in 1 patient. In 35.7% of cases the so called “dense artery sign” provided earliest evidence of the ensuing infarction documented by CT controls in most patients. Angiography carried out in 8 patients, density caculations in the course of the affected vessel and resolution of the increased density on subsequent CT examinations suggest thrombembolism as the most likely etiology. In the clinical setting of acute stroke increased artery density encompassing the entire vessel diameter may serve as an early indicator of major cerebral artery occlusion and prompt angiographic investigation of a lesion potentially amenable to lysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588557
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  • 10
    Electronic Resource
    Electronic Resource
    Intracellular localisation of phytochrome in oat coleoptiles by electron microscopy (1990)
    Springer
    Planta 180 (1990), S. 372-377 
    Details
    ISSN: 1432-2048
    Keywords: Avena (phytochrome) ; Phytochrome (destruction, localisation, sequestering)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The intracellular localisation of phytochrome in oat (Avena sativa L. cv. Garry Oat) coleoptiles was analysed by electron microscopy. Serial ultrathin sections of resin-embedded material were indirectly immunolabeled with polyclonal antibodies against phytochrome together with a gold-coupled second antibody. The limits of detectability of sequestered areas of phytochrome (SAPs) were analysed as a function of light pretreatments and amounts of the far-red absorbing form of phytochrome (Pfr) established. In 5-d-old dark-grown Avena coleoptiles SAPs were not detectable if less than 13 units of Pfr — compared with 100 units total phytochrome of 5-d-old dark-grown seedlings — were established by a red light pulse. In other sets of experiments, seedlings were preirradiated either with a non-saturating red light pulse to allow destruction to occur or with a saturating red followed by a far-red light pulse to induce first SAP formation and then its disaggregation. These preirradiations resulted in an increase of the limit of detectability of SAP formation after a second red light pulse to 38–41 and 19–23 units Pfr, respectively. We conclude that with respect to Pfr-induced SAP formation an adaptation process exists and that our data indicate that SAP formation is not a simple self-aggregation of newly formed Pfr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198788
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