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  • 1
    Electronic Resource
    Electronic Resource
    Histamine release during induction of anaesthesia and preparation for operation in patients undergoing general surgery: Incidence and clinically severe cases (1992)
    Springer
    Inflammation research 36 (1992), S. C149 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine release events were shown in a prospective randomized controlled trial in patients undergoing elective general surgery with an extraordinarily high incidence: 73 per cent. This high incidence was explained by several factors: — the sample size which was much greater than in previous studies — the improved plasma histamine assay — the precise definition of histamine release in clinical conditions and its measurement at the top of Bateman functions — the standardized induction of anaesthesia and preparation of the surgical patient — and finally the considerable number of cancer patients since more than 60% of the reactions 〉5 ng/ml occurred in this group which comprised only 20% of the study population. Two cases of life-threatening anaphylactoid reactions occurred in this trial corresponding to an incidence of 1 per cent. This was — again — very high compared to previous epidemiological studies. Both cases were again cancer patients and occurred in the placebo group — information given by the external study advisory group for further treatment of the individual patient. The data on the high incidence of histamine release including the high incidence of life-threatening reactions favourrationally a preoperative H1 −+H2-prophylaxis with the drugs used in this study: dimetindene and cimetidine. The question of the incidence was one of the unsettled problems which led to this trial. Analysis of the first 180 patients already answered this question more than we had ever expected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997321
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Vergleich der DNS-Analyse mit histomorphologischen parametern beim Magenkarzinom (1992)
    Springer
    Langenbeck's archives of surgery 377 (1992), S. 4-8 
    Details
    ISSN: 1435-2451
    Keywords: Stomach carcinoma ; DNA content ; Histomorphological parameter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am Tumormaterial von 103 Patienten nach kurativer Resektion wegen eines Magenkarzinoms wurde ein Vergleich des DNS-Gehaltes der Tumorzellen mit den histomorphologischen Parametern vorgenommen. Es zeigte sich, daß der DNS-Gehalt mit den histomorphologischen Parametern korreliert, ohne jedoch eine weitere prognostische Aussage zu ermöglichen. In der multivariaten Regressionsanalyse zur Beurteilung der prognostisch unabhängigen Variablen war demzufolge die rezidivfreie Überlebenszeit allein von der Infiltrationstiefe des Tumors und dem Lymphknotenstatus abhängig. Keinen Einfluß auf die rezidivfreie Überlebenszeit hatten der histologische Tumortyp, die Tumorlokalisation, das Operationsverfahren und der DNS-Gehalt.
    Notes: Summary After curative resection of stomach carcinomas (adenocarcinomas: n=58, signet ring cell carcinomas: n = 24, undifferentiated carcinomas: n = 21) the DNA content of the tumor cells was compared with the histomorphological parameters. There was a correlation between the DNA content and the histomorphological parameters. The DNA analysis had no additionally prognostic influence. In the multivariate regression analysis the prognosis depended on lymph node status (p=0.0009), pT-stage (p = 0.02), tumor localization (p = 0.03) and the histological type (p=0.05). The prognosis was independent of the DNA content. Furthermore, neither did the degree of differentiation, the operative procedure, the safety distance, the size of the tumor, the sex nor the age of the patient have any influence on the prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186141
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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