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  • 1
    Digitale Medien
    Digitale Medien
    Immunogenicity of HILDA/LIF either in a Soluble or in a Membrane Anchored Form expressed In Vivo by Recombinant Vaccinia Viruses (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 38 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Insertion of various cDN As in the genome of the vaccinia virus (VV) enables the in vivo and in vitro study of the functional role and/or the immunogenicity of the virally encoded recombinant proteins. We have prepared a recombinant VV expressing the cDNA of the human cytokine HILDA/LTF (human interleukin for DA cells/leukaemia inhibitory factor), and used this virus to immunize mice against this protein, which is very homologous to its murine counterpart (∼80% homology). We also constructed and expressed by the same system a chimeric gene encoding the HILDA/LIF protein fused to the 37 COOH-terminal amino-acids of the human decay accelerating factor (DAF). This sequence proved to be sufficient for the targeting of the fusion protein to the cell membrane, where it is linked to the phosphatidylinositols. Both recombinant VVs induced cytokine-specific antibodies in mice as analysed with an FLISA where the recombinant HILDA/LIF was plastic-coated and a cytofluorometric assay where the LIF-DAF molecule was present at the cell surface of stably transfected PS15. In the latter case HILDA/LIF remained biologically active suggesting that it was expressed in its native form. The LIF-DAF fusion protein was found to exhibit a better capacity to elicit an antibody response against the native form of the cytokine as detected in cytofluorometric assays. Whatever the recombinant virus used to immunize the mice, the MoAbs obtained were positive either in the ELISA or in the cytofluorometric assays but one, which suggested that the plastic coating induced a conformationa1 change of HILDA/LIF.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb01728.x
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  • 2
    Digitale Medien
    Digitale Medien
    Immune repertoire of graft-invading T cells (1990)
    Springer
    Transplant international 3 (1990), S. 176-180 
    Details
    ISSN: 1432-2277
    Schlagwort(e): T-cell repertoire ; Organ transplantation, T-cell repertoire ; Rejection, T-cell repertoire
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The immune repertoire of T lymphocytes invading human allografts is of fundamental importance both at the operational level, in order to achieve relevant matching, and at the functional level, since the unique capacity of T and B cells to specifically recognize allogeneic components restricts the origin of the signals leading to rejection by these cells. In this paper, the authors review their own work, as well as other contributions in this domain, with special reference to the frequency and function of donor-committed cells among the infiltrate and the relationship between T-cell receptor gene rearrangements and repertoire.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00355467
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  • 3
    Digitale Medien
    Digitale Medien
    0.5 T MRI of small renal masses: value of T2-weighted and Gd-DOTA-enhanced images (1993)
    Springer
    European radiology 3 (1993), S. 447-452 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Gadolinium ; Kidney, benign tumours ; Kidney, cysts ; Kidney, MRI studies ; Kidney, neoplasms ; MRI, contrast enhancement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We compared the value of T2-weighted and Gd-DOTA-enhanced T1-weighted images for the detection and characterisation of 33 small renal masses (14 clear cell carcinomas, 6 angiomyolipomas, 3 angiomyomas, 4 adenomas, 3 papillary carcinomas, 3 oncocytomas, 1 haemorrhagic cyst). Dynamic enhanced MRI was performed to study the tumoral vascular supply (19 cases). MRI depicted all the masses more than 1 cm in diameter, but missed all the lesions less than 1 cm (4 false-negative). The results of T2-weighted images and Gd-DOTA-enhanced images were similar as regards detection; however, Gd-DOTA-enhanced images depicted more clearly the tumours smaller than 2 cm (11 cases). MRI enabled the characterisation of only 3 masses (2 angiomyolipomas, 1 haemorrhagic cyst). New MRI features are described for oncocytomas (low signal intensity on T1-weighted images, high signal intensity on T2-weighted images, early and marked enhancement on dynamic enhanced MRI). Dynamic enhanced MRI did not contribute to the differentiation of benign from malignant tumours.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00221422
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  • 4
    Digitale Medien
    Digitale Medien
    Distinct presentations of radiocontrast-induced sialadenitis in renal insufficients and in patients with normal renal function (1994)
    Springer
    European radiology 4 (1994), S. 254-257 
    Details
    ISSN: 1432-1084
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report two incide ntal observations of radiocontrast-induced sialadenitis which occurred in a patient with normal renal function and in another patient undergoing chronic haemodialysis. Our first observation consisted of parotid gland, enlargement noted 1 h after contrast injection and which presaged anaphy lactoid shock. In the second cast salivary gland enlargement developed 3 days after administration of iodinated agent. A review of the literature based on 27 published observations. In dicates that two different presentations of iodide-induced sialadenitis canbe recognisedaccording totheirpathogenesis. In patients with normally functioning kidneys, the occurrence of sialadenitis after a shortdelay(5 min to 24 h) evokes an anaphylactoidmechanism. Conversely, in patients with impaired renal function, the delayed onset (1–5 days) of this adverse reaction suggest a toxic effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00606456
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