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  • 1
    Electronic Resource
    Electronic Resource
    Increased calmodulin levels in fibroblasts from progressive systemic sclerosis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 126 (1992), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Calmodulin levels in cultured skin fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were measured by their ability to activate cyclic AMP-phosphodiesterase. Calmodulin levels were significantly increased in PSS fibroblasts compared with normal control fibroblasts. The changes in calmodulin content of PSS fibroblasts were also assessed by a radioimmunoassay. These findings suggest that an elevated of calmodulin may play a role in the pathogenesis of PSS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1992.tb00650.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Eye velocity is not the major factor that determines mossy fiber responses of rabbit floccular Purkinje cells to head and screen oscillation (1990)
    Springer
    Experimental brain research 80 (1990), S. 221-224 
    Details
    ISSN: 1432-1106
    Keywords: Vestibulo-ocular reflex ; Optokinetic eye movement response ; Flocculus ; Purkinje cell ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single-unit activities were recorded from floccular Purkinje cells in 29 alert pigmented rabbits. The floccular areas specifically related to horizontal eye movement (H-zone) were identified by the effects of local stimulation and later confirmed histologically. Most of the 53 H-zone Purkinje cells responded to both vestibular stimulation with turntable oscillation (5° peak-to-peak, 0.1 Hz) in darkness and optokinetic stimulation with dot screen oscillation (2.5°, 0.33 Hz), often showing a preference either for turntable oscillation or screen oscillation. Since these responses were not correlated with the velocity of evoked eye movements or eye position shift, it is concluded that the major inputs to flocculus H-zone Purkinje cells are head velocity or retinal slip signals rather than eye velocity or position signals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228867
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Intra-arterial chemotherapy for brain stem glioma: report of four cases (1994)
    Springer
    Neuroradiology 36 (1994), S. 74-79 
    Details
    ISSN: 1432-1920
    Keywords: Brain stem glioma ; Intra-arterial chemotherapy ; ACNU ; Cisplatin ; Carboplatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four patients with pontine gliomas were treated with radiation and intra-arterial chemotherapy using ACNU, cisplatin, and/or carboplatin. All underwent biopsy and were histologically proven to have gliomas. Even though three were benign histologically, all appeared malignant on neuroimaging. Two patients had complete remissions; the others had partial responses; three patients died, 36, 14, and 15 months after the primary diagnosis. One patient, now in complete remission, has been alive for 24 months. There was no neurotoxicity except for transient nausea and vomiting. Intra-arterial chemotherapy is effective against brain stem gliomas, producing remission with minimum side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00599203
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Alterations in intracellular calcium transients of fibroblasts from progressive systemic sclerotic patients: a digital imaging microscopic study (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 96-99 
    Details
    ISSN: 1432-069X
    Keywords: Intracellular free calcium ; PSS ; Fibroblast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular Ca2+ concentrations ([Ca2+]i) in cultured skin fibroblasts from normal subjects and progressive systemic sclerosis (PSS) patients were determined by using Fura-2 and fluorescent videomicroscopy. With the exception of fibroblasts from one PSS patient showing a higher [Ca2+]i, no significant difference was observed in resting [Ca2+]i between the two groups of fibroblasts. Bradykinin (BK) (10 ΜM) induced a transient [Ca2+]i increase in normal fibroblasts, whereas the BK-induced [Ca2+]i increase was reduced or not detectable in PSS fibroblasts. Removal of extracellular Ca2+ did not eliminate the BK-induced [Ca2+]i increase in normal fibroblasts. These findings suggest that BK stimulates Ca2+ release from intracellular stores in human fibroblasts, and also that the BK-mediated Ca2+ release is impaired in PSS fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371616
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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