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  • 1
    Electronic Resource
    Electronic Resource
    Insertion of Filamin into Lipid Membranes Examined by Calorimetry, the Film Balance Technique, and Lipid Photolabeling (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 12565-12572 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00208a006
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of isomer separation on carbon-clad microporous zirconia and on conventional reversed-phase high-performance liquid chromatography supports (1990)
    s.l. : American Chemical Society
    Analytical chemistry 62 (1990), S. 2620-2625 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00222a019
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Class differentiation of immunoglobulin-containing cerebrospinal fluid cells in inflammatory diseases of the central nervous system (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 12-17 
    Details
    ISSN: 1432-1440
    Keywords: Immunoglobulin-containing cells ; Cerebrospinal fluid ; Immunocytochemistry ; Inflammatory diseases ; HIV-encephalitis ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunocytochemical technique allowing repeated use of antisera is applied to identify immunoglobulin-containing cells (ICC) of the IgG, IgA, and IgM class in the cerebrospinal fluid (CSF) of 298 patients with various neurological disorders. The demonstration of ICC in the CSF is highly indicative of an inflammatory disease (p〈0.0001; Chi-square test). In the group of noninflammatory disorders ICC are only found in three cases of lymphomas, two dysgerminomas, and one glioblastoma. ICC of all classes are seen in acute viral and bacterial infections of the CNS including tick-borne meningopolyneuritis Bannwarth. IgG-positive ICC predominate in chronic inflammatory disorders like multiple sclerosis and HIV encephalitis. In HIV-positive patients IgA-or IgM-positive cells are strongly indicative of an opportunistic infection of the brain. Persistent high levels of ICC in three patients with bacterial meningitis are associated with a fatal outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01648883
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  • 4
    Electronic Resource
    Electronic Resource
    The one-dimensional Coulomb potential as a generalized function and the hidden O(2) symmetry (1990)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 31 (1990), S. 1441-1444 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The one-dimensional hydrogen atom treating the potential, –λ /||x||, is solved as a generalized function. The solutions (although nondegenerate) are nonunique unless fixed by some physical constraint. It is also shown that the hidden O(2) symmetry is a consequence of using solutions that are eigenfunctions of the operator sgn x≡x/||x||.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.528734
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  • 5
    Electronic Resource
    Electronic Resource
    The influence of penbutolol and placebo on blood sugar levels and insulin consumption in the glucose-controlled insulin infusion system (“Artificial endocrine pancreas”) (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 951-958 
    Details
    ISSN: 1432-1440
    Keywords: Beta-blocker ; Diabetes mellitus type I ; Physical exercise ; Glucose contraregulating hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the study was to investigate the influence of 40 mg of the beta-blocker penbutolol (BetapressinTM; Hoechst Ltd., Frankfurt/ Main) in comparison to placebo on the insulin consumption on the blood sugar profile in twelve insulin-dependent diabetes (IDDM) patients. The patients were treated with penbutolol and placebo for a period of three days, and then were examined with the help of the glucose-controlled insulin infusion system. The blood sugar profile and insulin consumption over a 24 hour period was not affected by either penbutolol or placebo, nor could any changes be measured in these parameters when measured after food intake. After a submaximal exercise load on the bicycle ergometer (1 watt per kg body weight) following an evening meal, no difference could be observed between penbutolol and placebo in the above-mentioned parameters. The same was also true for hormonal parameters as STH, ACTH, cortisol, and catecholamines. These findings demonstrated that medication of penbutolol over a three-day period has no influence on the baseline blood sugar profile and insulin consumption or on insulin consumption after food intake during rest and physical exercise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646653
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  • 6
    Electronic Resource
    Electronic Resource
    Differential diagnosis of HTLV-I-associated myelopathy and multiple sclerosis in Iranian patients (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 1013-1018 
    Details
    ISSN: 1432-1440
    Keywords: HTLV-I-associated myelopathy ; Tropical spastic paraparesis ; Multiple sclerosis ; Human T-cell leukemia virus I ; Polymerase chain reaction ; HTLV-I antibodies ; Enzyme-linked immunosorbent assay ; Cerebrospinal fluid ; Intrathecal antibody synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two Iranian patients with chronic progressive spastic paraparesis and urinary dysfunction were referred to our hospital with the presumptive diagnosis of multiple sclerosis (MS). Routine CSF analysis and magnetic resonance imaging of the two patients were only partially characteristic of MS. Testing for antibodies to human T-cell leukemia virus type I [HTLV-1] in serum using a radioimmune precipitation assay revealed antibodies to HTLV-I in both patients. The infection with HTLV-I was confirmed by polymerase chain reaction (PCR) and liquid hybridization analysis using primers to the tax/rex region and a corresponding probe, demonstrating proviral DNA in peripheral blood mononuclear cells of both patients. On the basis of these findings demonstrating the presence of proviral HTLV-1 DNA in the two Iranian patients, the initial diagnosis of MS was corrected to that of HTLV-I-associated myelopathy (HAM). In contrast, several patients with definite MS (nine from Germany, two from Iran) with a relapsing and remitting form of the disease were tested for HTLV-1 infection by enzyme-linked immunosorbent assay and PCR, which yielded negative results. However, the mother of one HAM patient was found to be infected with HTLV-I. To support an association between HTLV-I infection and CNS disease in the two HAM patients, we analyzed the production of specific IgG antibodies within the CNS based on a simple enzyme immunoassay for viral IgG antibodies in CSF and serum. In the two HAM patients there was significant intrathecal antibody production directed against HTLV-I, but this was not found in any of the samples from MS patients. These findings demonstrate an immune reaction to HTLV-I in the CNS of HAM patients, thus confirming the association of infection and CNS disease. The demonstration of intrathecal HTLV-I antibody production also proved useful for the differential diagnosis of MS or HAM, especially in patients from areas endemic for HTLV-I.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180311
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  • 7
    Electronic Resource
    Electronic Resource
    Comparative analysis of intrathecal antibody synthesis and DNA amplification for the diagnosis of cytomegalovirus infection of the central nervous system in AIDS patients (1994)
    Springer
    Journal of neurology 241 (1994), S. 407-414 
    Details
    ISSN: 1432-1459
    Keywords: Cytomegalovirus ; Acquired immunodeficiency syndrome ; Recombinant phosphoprotein (pp150) ; Intrathecal antibody synthesis ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated 49 paired cerebrospinal fluid (CSF) and serum samples of 35 patients infected with the human immunodeficiency virus type 1 (HIV-1) for laboratory evidence of cytomegalovirus (CMV) infection. The patients were grouped according to clinical criteria as probable CMV encephalitis/polyradiculomyelitis, CMV retinitis, cerebral toxoplasmosis, progressive multifocal leukoencephalopathy, HIV-1-related cognitive/motor complex, HIV-1-associated myelopathy, and other neurological diseases. Paired CSF and serum samples were analysed for CMV deoxyribonucleic acid (DNA) by polymerase chain reaction (PCR), quantitative intrathecal synthesis of immunoglobulin G (IgG) antibodies specific for recombinant phosphoprotein 150 (pp150) of CMV and CMV-specific serum IgM. Intrathecal synthesis of pp150-specific IgG was detected in 26% of patients (9/35), serum IgM was found in 23% of patients (8/35), and PCR of CSF was positive in 11% of patients (4/35). Detection of CMV-specific DNA in CSF preceded the intrathecal antibody synthesis in three patients for whom serial samples were available. PCR results of the CSF became negative in one patient with CMV polyradiculomyelitis after successful therapy with 9-[2-hydroxy-l(hydroxymethyl) ethoxymethyl] guanine (DHPG). PCR has a higher diagnostic specificity in the acute phase of CMV infection than intrathecal antibody synthesis. The serum IgM response to CMV cannot be used to monitor a compartmentalized immune response in the central nervous system while an intrathecal immune response seems to be associated with recovery either spontaneously or as a result of treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00900957
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  • 8
    Electronic Resource
    Electronic Resource
    A new function for an old structure: The “Timbal Muscle” in cicada females (1993)
    Springer
    Naturwissenschaften 80 (1993), S. 324-326 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01141906
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  • 9
    Electronic Resource
    Electronic Resource
    Experimental investigation of vibrational excitations in230Th (1994)
    Springer
    The European physical journal 350 (1994), S. 13-28 
    Details
    ISSN: 1434-601X
    Keywords: 23.20 ; 25.40 ; 27.90.+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Nuclear levels in230Th have been investigated in theβ decay of230Pa, the230Th(d, pnγ) reaction and the232Th(p, t) reaction. TheK π=0 1 + , 2 1 + , and 2 2 + bands with band heads at 635, 781, and 1010 keV were observed up to the 8+, 9+, and 7+ levels, respectively. A second excited 0+ level was identified at 1297 keV which might be interpreted as the usualβ shape-oscillation. The branching ratios of theE2 transitions from the 0 1 + , 2 1 + , and 2 2 + bands are explained in the framework of the rotational model by taking into account the coupling of these bands with the ground-state band, and the coupling between the 0 1 + and 2 1 + band. A strong enhancement ofE2 transitions from the 2 1 + to the 0 1 + band reported earlier is not confirmed. For the octupole vibrations withK π=0−, 1−, and 2− theE1 branching ratios are analyzed in terms of the Coriolis coupling of these bands. An almost complete experimental set ofE1 transition moments from these negative-parity bands to the 0 g + , 0 1 + , and 2 1 + bands was obtained. It is suggested that octupole correlations might be important in explaining theseE1 moments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01285047
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  • 10
    Electronic Resource
    Electronic Resource
    Ion-beam-induced atomic transport and phase formation in the system nickel/antimony (1993)
    Springer
    Applied physics 57 (1993), S. 343-351 
    Details
    ISSN: 1432-0630
    Keywords: 61.80 ; 68.35 ; 68.55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract We report on the ion-beam mixing processes of Sb/Ni marker layers and bilayers under the irradiation of ions ranging from He to Pb, at 80 K and at room temperature. The concentration profiles are obtained by Rutherford backscattering spectroscopy with 900 keV α-particles. At 80 K, the bilayer mixing rates cannot be reproduced by purely ballistic mixing; the essentially linear scaling of the bilayer mixing rate with the energy F D deposited at the interface points to local spike formation. A transition to global spike formation seems to be visible for the Pb-irradiations. Additional mixing effects at 300 K are due to radiation enhanced diffusion and scale with √F D. The marker mixing rates at 80 K are reproduced by the ballistic mixing approach, but are equally well described by local spike models. High fluence Xe-irradiations of Sb/Ni bilayers lead to intermetallic phases in the interface region as verified by transmission electron microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332288
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