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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 60 (1986), S. 2739-2753 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A model of cw argon ion lasers excited by low-energy (50–200 eV) direct current electron beams at current densities between 1 and 50 A/cm2 has been developed. The electron energy distribution in the electron-beam-created plasma is calculated by numerically solving the Boltzmann equation for electrons. Optical gains, powers, and laser efficiences were computed for the 4765-, 4880-, 4965-, and 4658-A(ring) Ar ii transitions for a wide range of discharge conditions. Laser efficiencies comparable to those of a conventional Ar ii laser (∼3×10−4) are predicted for these laser transitions when electron beam excitation is used.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 44 (1979), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: TO identify the most sensitive adverse effects of high dietary zinc, day-old Japanese quail (Coturnix coturnix juponica) were fed diets marginally deficient, adequate or slightly elevated in copper with supplements of 15.6–2000 ppm zinc. By 14 days of age, sensitive zinc antagonisms of copper, iron and manganese were evident. The supplemental zinc caused depressed growth, decreased feather pigmentation, mild perosis and anemia; the first three generally being more severe when dietary copper was marginally deficient. The duodenum and liver accumulated zinc in relation to the dietary zinc level. Supplemental zinc caused decreased levels of iron, manganese and copper in the liver. The adequacy of copper intake is important when zinc intake is increased by use of dietary supplements or fortification of foods.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 42 (1986), S. 551-553 
    ISSN: 1420-9071
    Keywords: Alopecia ; zinc excess ; mice ; copper deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Second generation mice were exposed to normal (50 ppm, Group I) or excess (2000 ppm, Group II) zinc in the maternal diet during gestation and lactation, then weaned and continued on the mother's diet until sacrifice at 8 weeks. Tibia zinc reflected dietary intake. Group II had reduced plasma copper, body weight, and hematocrit; the second coat of hair appeared late and was lighter in color than Group I, possibly as an effect of copper and pigmentation development and hair growth.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 43 (1987), S. 949-950 
    ISSN: 1420-9071
    Keywords: Marine sponge ; Luffariella sp. ; sesterterpene ; phospholipase A2 inhibitor ; anti-inflammatory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Luffariellolide (2) is a sesterterpene from the Palauan spongeLuffariella sp. that has useful anti-inflammatory properties. In contrast with the irreversible action of manoalide (1) on phospholipase A2, luffariellolide (2) is a slightly less potent but partially reversible PLA2 inhibitor.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 45 (1989), S. 388-390 
    ISSN: 1420-9071
    Keywords: Luffolide ; Luffariella sp ; X-ray structure determination ; anti-inflammatory ; phospholipase A2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Luffolide (4) is a minor metabolite of the spongeLuffariella sp. from Palau. The structure of luffolide was determined by single crystal X-ray analysis. Luffolide is relatively unstable and undergoes a complex cyclization reaction to give the hexacyclic products5 and6. Luffolide (4) has some of the anti-inflammatory properties of manoalide (1): this may help to define the chemical reaction between manoalide (1) and phospholipase A2.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Infection 17 (1989), S. 338-342 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Studien zur Pharmakokinetik von Cefotaxim/Desacetylcefotaxim wurden bei Neugeborenen mit sehr niedrigem Geburtsgewicht (n=18; 500–1500 g; Gestationsalter 28,4 ± 2,4 Wochen) während der ersten Lebenswoche durchgeführt. Wie wir bereits berichtet haben, ist die Eliminations-Halbwertzeit von Cefotaxim (3,4–6,4 h) und Desacetylcefotaxim (9,4 h) bei diesen Kindern länger als bei reifen Neugeborenen und Kindern beschrieben wurde. Bei Neugeborenen mit sehr niedrigem Geburtsgewicht kann es nach Gabe von Cefotaxim in einer Dosis von einmal 50 mg/kg täglich möglicherweise zur Akkumulation des Metaboliten Desacetylcefotaxim im Serum kommen. In einer prospektiven, nicht vergleichenden klinischen Studie wurde Cefotaxim in einer Dosis von 50 mg/kg/Tag bei 22 Säuglingen im Alter von einer Woche bis drei Monaten zur Behandlung einer Meningitis durch gramnegative Enterobakterien eingesetzt. Als häufigster Erreger wurdeEscherichia coli bei 14 Fällen isoliert, in vier FällenEnterobacter cloacae. Bei allen Kindern waren die Liquorkulturen 24–48 h nach Therapiebeginn negativ. 95% der Kinder überlebten, bei 19% traten Komplikationen auf. Diese Ergebnisse stimmen gut mit früheren Erfahrungen mit Alternativtherapien bei der Meningitis durch gramnegative Enterobakterien überein. Das Sicherheitsprofil war sowohl in der Pharmakokinetik- wie in der Meningitis-Therapiestudie ausgezeichnet, unerwünschte Reaktionen traten in keinem Fall auf.
    Notes: Summary Pharmacokinetic studies on cefotaxime/desacetylcefotaxime were carried out in very low birth weight newborns (n=18; 500–1500 g; 28.4±2.4 weeks gestational age) during the first week of life. We have previously reported that the elimination t 1/2 of cefotaxime (3.4–6.4 h) and desacetylcefotaxime (9.4 h) was longer than previously described in term infants and children. In very low birth weight neonates, a single 50 mg/kg daily dose of cefotaxime may produce accumulation of the metabolite desacetylcefotaxime in serum. In a non-comparative prospective clinical trail, 22 infants (one week — three months) were treated for gram-negative enteric bacillary meningitis with cefotaxime at a dosage of 50 mg/kg/day. The predominant pathogen wasEscherichia coli in 14 cases andEnterobacter cloacae in four cases. Cultures of the cerebrospinal fluid obtained 24–48 h after the initiation of treatment were sterile in all subjects. Survival and complication rates of 95% and 19%, respectively, were observed. This compared favorably to previously published experiences with alternative treatment regimens for neonatal gram-negative enteric meningitis. In both the pharmacokinetic and meningitis studies, the safety profile for cefotaxime was excellent with no adverse reactions.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-5117
    Keywords: Eudiaptomus ; year cycle ; sex ratio ; eggs ; spermatophores ; temperature ; development time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The development of a population of Eudiaptomus vulgaris (Schmeil, 1896) in the Meeuwenven, a shallow acid guanotrofic moorland pool, has been described during one year. The population hibernates as copepodite 5 stages, adults and, to a small extent as naupliar stages N1, N2 and N3 (which could not develop further at low temperatures in autumn). In spring the population development starts at temperatures above 10°C and shows 3 or 4 pulses a year. An attempt has been made to explain seasonal changes in the size of adult males and females and in the sex ratio. In order to establish the duration of the various development stages, the animals have been cultured at different temperatures under illumination with 2000 Lux at a daylength of 14 hours. An adequate quantity of food from the natural habitat was available. Total egg development and total naupliar and copepodite development have been compared with the results of other workers, especially with those from Eckstein (1964), who studied Eudiaptomus vulgaris in the deep Schluchsee. The duration curves do not differ markedly with those of Eckstein and are strongly temperature dependent. The relation between the development times of the various stages with temperature can be generally expressed as parabolic regressions of the type D = a + b1T + b2T2, the C5 and adult stages being the only exception at higher temperatures. Comparison of the relative duration of the stages at different temperatures did show that younger stages can take a larger share of the total development time at lower temperatures, stage N6 being the most temperature-sensitive.
    Type of Medium: Electronic Resource
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