Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1985-1989  (2)
  • 1975-1979  (9)
  • 1965-1969  (10)
  • 1
    Electronic Resource
    Electronic Resource
    Hämoglobin-Köln-Krankheit: Familiäre hypochrome hämolytische Anämie mit Hämoglobinanomalie (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 1049-1053 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An autosomal dominant hereditary haemoglobinopathy has been found in a German family. Analysis of the haemoglobin demonstrated a hitherto not described small fraction of abnormal haemoglobin which migrated on electrophoresis between Haemoglobin A1 and Haemoglobin A2. This fraction is named Haemoglobin Köln. Hybridisation with canine haemoglobin showed that the abnormality was in the β-chain and from examination of the tryptic peptides it could be concluded that this was situated between the amino-acid residues 83–120 of the β-chain. All carriers of this new haemoglobin fraction had a distinct haemolytic anaemia with anisocytosis, and macrocytosis and hypochromia of the erythrocytes. Many of the red cells showed basophil strippling. Osmotic resistance of the erythrocytes was slightly lowered. Splenomegaly was a constant symptom. In one patient a splenectomy had been carried out some time ago but at the time of the examination of the patient there was no evidence that it had benefited the patient as regards haemolysis and anaemia.
    Notes: Zusammenfassung Bei einer deutschen Familie wurde eine autosomal dominant erbliche neue Hämoglobinopathie beschrieben. Durch die Hämoglobinanalyse konnte bei den Trägern der Anlage eine bisher unbekannte kleine Hb-Fraktion festgestellt werden, die in der Elektrophorese zwischen Hb A1 und Hb A2 wandert. Diese Fraktion wird als Hb Köln bezeichnet. Durch Hybridisierung mit Hundehämoglobin ließ sich feststellen, daß die Anomalie in der β-Kette des Hämoglobins vorhanden ist. Auf Grund chromatographischer Untersuchungen konnte eine Strukturanomalie zwischen den Aminosäuren 83 und 120 der β-Ketten festgestellt werden. Alle Träger dieser neuen Hämoglobinfraktion hatten eine deutliche hämolytische Anämie mit Anisomakrocytose und Hypochromie der Erythrocyten. Zahlreiche Erythrocyten waren basophil punktiert. Die osmotische Erythrocytenresistenz war gering erniedrigt. Eine Splenomegalie war ein konstantes Symptom. Die in einem Fall früher ausgeführte Splenektomie war ohne Einfluß auf die Hämolyse und die Anämie geblieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746594
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    HbM Hamburg, eine β-Ketten-Anomalie: α2β 63 Tyr 2 (=HbM Saskatoon) (1966)
    Springer
    Journal of molecular medicine 44 (1966), S. 961-966 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a north german family which shows cyanotic members in three generations, it was found that HbM was the cause of the cyanosis. One child was observed from birth. It developed the characteristic cyanosis within a few weeks indicating that the anomaly was in theβ-chain of the haemoglobin. This was shown to be correct by hybridisation of the haemoglobin with dog haemoglobin. The investigation of the tryptic peptides of theβ-chain isolated from globin by counter-current distribution, by „fingerprint”, gave an anomalous peptideβT7. Quantitative amino-acid analysis of this peptide showed that it lacked histidine but contained tyrosine instead, from which it follows that there is an exchange of tyrosine for histidine in position 63 of theβ-chain. This corresponds to the arrangement in HbM Saskatoon.
    Notes: Zusammenfassung In einer norddeutschen Familie, die cyanotische Individuen in 3 Generationen aufweist, wurde HbM als Ursache der Cyanose festgestellt. Ein Kind konnte von Geburt an beobachtet werden; es entwickelte erst im Ablauf einiger Wochen die charakteristische Cyanose. Daraus war abzuleiten, daß die Anomalie in derβ-Kette des Hämoglobins liegen mußte. Dies ließ sich im Hybridisierungsexperiment mit Hundehämoglobin als zutreffend erweisen. Die Untersuchung der Peptide der durch Gegenstromverteilung aus Globin isoliertenβ-Kette mittels „fingerprint“ ergab ein anomales PeptidβT7. Die quantitative Aminosäureanalyse dieses Peptids zeigte, daß darin Histidin fehlte, dagegen Tyrosin vorhanden war, woraus folgt, daß in Position 63 derβ-Kette ein Histidin-Tyrosin-Austausch vorliegt. Das entspricht den Verhältnissen in HbM Saskatoon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711469
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Embryonale Hämoglobine (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 435-437 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Recent work byHuehns et al. gives good evidence that the two prefoetal blood pigments Gower 1 and Gower 2 are normal hemoglobins in the early development of human embryos. These two embryonic hemoglobins with a slow anodic mobility similar to HbC are regulary detected in embryos with a crown-rump length under 10 cm. Chemical properties, polypeptide chain composition and occurrence in the newborn are dicussed by the authors. In this paper the existence of human embryonic hemoglobin is confirmed by starch-gel electrophoresis in blood samples of four young embryos with a crown-rump length ranging from 2.5 to 5.5 cm. In comparative studies embryonic hemoglobins were also found in cow embryos with a crown-rump length between 1 and 7 cm.
    Notes: Zusammenfassung Die vonHuehns u. Mitarb. genauer beschriebenen embryonalen Blutfarbstoffe Gower 1 und Gower 2 ließen sich im Hämolysat des Blutes einer 5,5 cm langen menschlichen Frucht durch die Stärkegelelektrophorese nachweisen. Sie fanden sich außerdem auf der Photographie einer Stärkeblockelektrophorese aus dem Jahre 1960 von Hämolysat einer 3,5 cm langen menschlichen Frucht. Im Blut eines 1 cm langen Rinderembryo wurden neben fetalem Rinder-Hb drei langsam wandernde Hb-Fraktionen festgestellt, die offensichtlich ebenfalls als embryonale Hämoglobine anzusehen sind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483849
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Estimation and prediction of blood volume in infants and children (1977)
    Springer
    European journal of pediatrics 125 (1977), S. 227-234 
    Details
    ISSN: 1432-1076
    Keywords: Blood volume ; Height ; Weight ; Body surface area ; Infancy ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood volume was studied in 160 infants and children aged from one hour to 14 years. From these data linear and logarithmic regression equations relating blood volume to weight, height and surface area were calculated. Equations utilizing combined height and logarithmic weight values were found to be the most accurate for predicting blood volume. Therefore, nomograms were constructed for reading blood volume directly from height and weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493567
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Haemoglobin A2 in newborn infants of different maturity (1987)
    Springer
    European journal of pediatrics 146 (1987), S. 598-600 
    Details
    ISSN: 1432-1076
    Keywords: Haemoglobin switch ; Hb A2 ; Maturity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From 70 infants born after gestation periods of 28–41 weeks Hb F and Hb A2 were determined in the cord blood; Hb A was calculated from the two values. Hb F decreased with maturity, Hb A and Hb A2 increased. The percentage of Hb A2 calculated from the sum of Hb A+Hb A2 (non-fetal Hb) increased from 0.57% to 0.83% with maturity. These values are much lower than those in adult controls (1.83%). The results show that during development the synthesis of the δ-globin chains lags behind that of the β-globin chains. This is remarkable considering the location of the δ-globin gene within the β-globin like gene cluster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467363
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Peripheral circulation in the newborn: Interaction of peripheral blood flow, blood pressure, blood volume, and blood viscosity (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 73-81 
    Details
    ISSN: 1432-1076
    Keywords: Blood pressure ; Blood viscosity ; Blood volume ; Newborn infants ; Peripheral blood flow ; Peripheral resistance ; Premature infants ; Respiratory distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral blood flow and systolic blood pressure (strain-gauge plethysmograph), blood volume (Evans blue) and whole blood viscosity (cone-plate viscometer) have been measured in 66 premature and full-term infants 6 to 144h of age. Blood flow and blood volume were moderately decreased in the infants with respiratory distress. Highly significant (P〈0.001) correlations were found betwen blood flow and blood volume (r=0.77), blood pressure and blood volume (r=0.50), peripheral resistance and blood volume (r=-0.44), blood flow and blood pressure (r=0.50), blood flow and peripheral resistance (r=-0.67), peripheral resistance and blood viscosity (r=0.45), and blood viscosity and haematocrit (r=0.86). There was no correlation between peripheral blood flow and blood viscosity. However, at given blood volume, peripheral blood flow decreased with increasing blood viscosity. These results indicate that in newborn infants peripheral blood flow, blood pressure and peripheral resistance are influenced by blood volume, but also depend on blood viscosity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442366
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The effect of intra-partum and intra-uterine asphyxia on placental transfusion in premature and full-term infants (1978)
    Springer
    European journal of pediatrics 127 (1978), S. 91-99 
    Details
    ISSN: 1432-1076
    Keywords: Newborn infants ; Premature infants ; Asphyxia ; Caesarean section ; Nuchal cord ; Blood volume ; Red cell mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood volume and its components were estimated using 125iodinated human serum albumin in 194 newborn infants with 26 to 41 week gestations. Umbilical cords were ligated 15 seconds after vaginal delivery (n=141) and within 5 seconds after delivery by Caesarean section (n=53). The infants were divided into four groups according to the mode of delivery and presence of prenatal complications: group I: vaginal deliveries (n=96) and group II: Caesarean section (n=25) without preceding complications; group III: infants with intra-uterine asphyxia (n=56); group IV: infants with tight umbilical cord loops around neck (n=17). Subgroups were established with respect to gestational age and to one-minute Apgar scores. Significantly different blood volume (BV) and red cell mass (RCM) values between the subgroups were only found in group I with respect to different Apgar scores: Ia Apgar〉5: BV 77.9±6.2; RCM 37.5±5.1 ml/kg; Ib Apgar〈6: BV 70.0±4.4; RCM 29.6±2.9 ml/kg (P〈0.005). Intra-partum asphyxia did not affect BV (71.3±4.8 ml/kg) and RCM (31.2±3.6 ml/kg) in group II. BV and RCM were significantly (P〈0.005) lower than in group Ia. In group III, BV (90.4±7.0 ml/kg) and RCM (46.9±6.3 ml/kg) were significantly (P〈0.005) higher than in group I, irrespective of the mode of delivery and Apgar scores. The infants of group IV had the lowest volumes (BV 67.5±5.7; RCM 27.4±2.7 ml/kg). Values obtained in premature and full-term infants were similar in the respective groups. These results indicate that infants with intra-partum asphyxia and with tight nuchal cords do not participate in placental transfusion or even lose some blood into the placenta. However, infants with intrauterine asphyxia (excepting those with tight nuchal cords) receive marked placental transfusion in utero.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445764
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Switch of delta and beta chains in fetus (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 666-667 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442494
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Association of neonatal respiratory distress with birth asphyxia and deficiency of red cell mass in premature infants (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 167-173 
    Details
    ISSN: 1432-1076
    Keywords: Premature infants ; Respiratory distress ; Apgar score ; Asphyxia ; Red cell mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Red cell mass (RCM) was estimated using 125I-labelled human serum albumin in 128 premature infants born after 26 to 36 weeks gestation. Infants of three different gestational periods (26–29, 30–32, and 33–36 weeks) with respiratory distress (RD) averaged lower one-minute Apgar scores and lower RCM than infants without RD (P〈0.05). The incidence of RD was significantly (P〈0.05) higher in infants with Apgar scores below 6 and in infants with RCM of less than 35 ml/kg than in the infants with greater values. The highest incidence of RD and the highest mortality rate were found in the infants with low Apgar scores and low RCM values. Prematures with similar Apgar scores showed a higher incidence of RD when RCM was low, and infants with similar RCM showed a higher incidence of RD when Apgar scores were low. Our results suggest that both birth asphyxia and deficiency of red cell mass interfere with postnatal cardio-respiratory adaptation. In high-risk premature infants, erythrocytes should be transfused when the venous haematocrit is below 0.45.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442160
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Capillary-venous hematocrit differences in newborn infants (1977)
    Springer
    European journal of pediatrics 127 (1977), S. 9-14 
    Details
    ISSN: 1432-1076
    Keywords: Newborn infants ; Blood pressure ; Hematocrit ; Blood volume ; Acid-base status ; Red cell mass ; Peripheral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Venous and capillary hematocrit, acid base values, and circulatory parameters were measured simultaneously in 92 newborn infants within six hours of birth. Gestational age ranged from 26 to 41 weeks. The capillary/ venous hematocrit ratio (Hctc/Hctv) was greater than 1.00 in 89 infants. We found significant inverse correlations between Hctc/Hctv and several parameters, such as pH (r=-0.82), standard bicarbonate (r=-0.73), systolic blood pressure (r=-0.51), and peripheral blood flow (r=-0.70). Most of the infants with a Hctc/Hctv of 1.20 and above had red cell mass values of less than 35 ml/kg. However, blood volume apparently did not influence the Hctc/Hctv. Gestational age appeared to affect Hctc/Hctv only before 30 weeks, when compared with the Hctc/Hctv of term infants. Our results indicate that disturbed circulation, and in particular, disturbed microcirculation, is involved in the development of high Hctc/Hctv ratios. We strongly advise that hematocrits obtained by skin prick from a sick newborn infant should not be relied on as they may give misleading information on oxygen carrying capacity to vital organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465560
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...