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  • 1
    Electronic Resource
    Electronic Resource
    Formation and propagation of brain oedema fluid around human brain metastases. A CT study (1988)
    Springer
    Acta neurochirurgica 90 (1988), S. 35-41 
    Details
    ISSN: 0942-0940
    Keywords: Brain oedema ; brain tumours ; oedema formation ; oedema propagation ; dexamethasone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Computerized tomography (CT) was used to examine the timecourse of the propagation of extravasated contrast medium from small brain metastases into the peritumoural oedematous white matter, following infusion of 200 ml of meglumine amidtrizoate for 3 hours. Four patients with a metastatic brain tumour were examined. CT scans at identical levels were taken 1.5, 3, 6, 9, and 12 hours after start of contrast infusion. Following 4–7 days of dexamethasone treatment (8–12mg/day i.v.) the examination was repeated. A contrast-enhanced area was observed surrounding the clearly delineated tumours, expanding gradually in a circular fashion into the peritumoural white matter oedema. The expanding circular enhancement was measured planimetrically on the various scans. From these values, the increase in radius/hr respectively in volume/hr was calculated, assuming a spherical geometry. This enabled a determination of the rate of oedema fluid formation and of the speed of oedema fluid propagation. The formation rate of oedema fluid amounted to 0.5–3.2ml/hour and the speed of oedema fluid spreading to 1.9 mm/hour. Following treatment with dexamethasone the formation rate of oedema fluid is reduced by 30–50%. The important clinical implications of these new findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541264
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  • 2
    Electronic Resource
    Electronic Resource
    Aneurysms of the peripheral portion of the anterior inferior cerebellar artery; Report of two cases (1987)
    Springer
    Neuroradiology 29 (1987), S. 493-496 
    Details
    ISSN: 1432-1920
    Keywords: Anterior inferior celebellar artery ; Aneurysm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases of extremely rare aneurysms of peripheral portions of the AICA are reported with a review of the pertinent literature. According to reported surgical findings, nearly all of the aneurysms originated from arterial loops near the internal acoustic meatus. These aneurysms can therefore, cause the cerebellopontine angle syndrome, with or without subarachnoid hemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341751
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A comparative immunohistochemical study of calcineurin and S-100 protein in mammalian and avian brains (1988)
    Springer
    Experimental brain research 69 (1988), S. 645-650 
    Details
    ISSN: 1432-1106
    Keywords: S-100 protein ; Calcineurin ; Mammalian brain ; Avian brain ; Vertebrate brain ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cellular and topographic localization of calcineurin and S-100 protein was examined immunohistochemically in the mammalian and avian brain. Calcineurin immunoreactivity in both the avian and mammalian brain was located only in neuronal cells. S-100 protein was localized mainly in the glial and Schwann cells within the mammalian brain. However, in the avian brain, neuronal cells in certain regions such as the paleostriatum primitivum and the cerebellum, as well as other non-neuronal cells, exhibited S-100 protein immunoreactivity. A distinct difference was demonstrated in the macroscopic topographic distribution patterns of S-100 protein immunoreactivity between the mammalian and avian brains, while the patterns of calcineurin distribution were essentially identical. In addition, we provided calcineurin- and S-100 protein-immunocytochemical results for the turtle, frog and fish brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247316
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  • 4
    Electronic Resource
    Electronic Resource
    Co-expression and inheritance of foreign genes in transformants obtained by direct DNA transformation of tobacco protoplasts (1986)
    Springer
    Molecular genetics and genomics 205 (1986), S. 1-8 
    Details
    ISSN: 1617-4623
    Keywords: Nicotiana tabacum ; Protoplasts ; DNA transformation ; APH(3′)II ; Nopaline synthase ; Inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A plasmid containing two marker genes for expression in plants was constructed. This 16 kb vector, pCT1T3, contains an intact nopaline synthase gene and a chimaeric gene consisting of the promoter and terminator regions from cauliflower mosaic virus gene VI and a structural gene, aminoglycoside phosphotransferase (APH(3′)II), from the bacterial transposon Tn5. After transformation of tobacco mesophyll protoplasts with this plasmid, several kanamycin-resistant transformants were obtained. Intensive studies on the drug tolerance of growth and differentiation of the transformants showed that the chimaeric gene was stably expressed. Of 17 independent transformants, 3 (about 18%) expressed the two marker genes, regardless of the state of differentiation, as did individual plants regenerated from the same callus. Multiple copies of the inserted DNA were found in some transformants. Viable seeds were produced by 12 out of 15 independent transformants. Seeds obtained by self-pollination were germinated on medium containing kanamycin sulphate. With the exception of one clone, resistant seedlings with green leaves and sensitive seedlings with white leaves were found to segregate in a 3:1 ratio. This suggests that the inheritance of the inserted gene is Mendelian. A reciprocal cross between the transformants and wild-type tobacco also showed nuclear transmission of the APH(3′)II gene. This was consistently maintained in a subclone of the same transformant derived from the same callus line. Stable inheritance of the single dominant character was also seen among seeds formed in several different flower pods of the same individual plants. Two clones were also found to synthesize nopaline in addition to expressing APH(3′)II. Analysis of the progeny obtained by self-crosses of such transformants revealed the simultaneous expression of these two enzymes, indicating that the two marker genes are linked on the same chromosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02428025
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    Paper (German National Licenses)
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