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  • 1
    Electronic Resource
    Electronic Resource
    Cerebral amyloid angiopathy and astrocytic gliosis in Alzheimer's disease (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 329-331 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid angiopathy ; Astrocytic gliosis ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Astrocytic reaction at amyloid infiltrated cortical vessels was studied using glial fibrillary acidic protein (GFAP) stain in two cases of Alzheimer's disease (AD). Sections from the visual and prefrontal cortex were stained with H&E, Bodian, Congo red, and thioflavin S in addition to GFAP. Senile plaques and neurofibrillary tangles were present in both cases. The density of astrocytes surrounding vessels infiltrated with amyloid was variable. In the same area, there were vessels with minimal perivascular astrocytic reaction as well as vessels displaying more pronounced perivascular gliosis; there was no constant excessive gliosis around vessels with severe amyloid deposits. However, if amyloid infiltrating the vessel wall protruded into the perivascular neuropil of the cortex, then prolific reaction of astroglia, similar to that seen at interstitial senile plaques was apparent, and a neuritic component was distinct. It appears that once amyloid of AD type is deposited in the neuropil, whether in form of interstitial plaque or perivascular plaque, it causes a similar astroglial and neuritic reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687764
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of treatment withCorynebacterium parvum on the development and growth of experimental hematogenic metastases of schwannoma in the rat (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 22-26 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single i.v. administration ofCorynebacterium parvum 5 days before i.v. injection of 106 tissue cultured syngeneic schwannoma cells in Lewis rats resulted in extension of survival time (P〈0.05). There was a significant decrease in metastatic tumor incidence for lung, heart, and kidney and decreased lung tumor growth with approximately 50% of the lung tumor burden of untreated controls (P〈0.05). Rats treated similarly withC. parvum 10 days after tumor cell injection showed no enhanced survival; to the contrary, their survival was shortened. Moreover, tumor incidence in the post-treated group was not significantly different from the control but significantly increased in comparison to the pretreated group. Enhanced lung tumor growth resulted in a final tumor burden about twice that of untreated controls (P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688951
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cerebral aging: a quantitative study of gliosis in old nude mice (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 507-513 
    Details
    ISSN: 1432-0533
    Keywords: Aging ; Astrocytes ; Glial fibrillary acidic protein ; Nude mice ; PAS-positive granules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphometric glial fibrillary acidic protein (GFAP) studies of the brains of 11 old (18–29 months) female, outbred athymic mice demonstrated astrocytic gliosis (increase in GFAP-positive astrocytes; GFAP-PA) in all mice with a consistent distribution pattern. Specific areas such as the central white matter, hippocampus, diencephalon, gray matter at the floor of the 4th ventricle, and posterior colliculi showed the change most conspicuously, revealing GFAP-PA both interstitially and perivascularly. There was no apparent demyelination in the affected white matter. In addition, there was an increase in GFAP-PA in the external limiting membrane surrounding the diencephalon and base of brain stem, but only to a minor degree over the cerebral hemispheres. The cerebral and cerebellar cortices and hypothalamus showed no significant increase. In contrast, all of the 2-month-old control animals showed only minor amounts of GFAP-PA, seen in the external limiting membrane and a trace in the cerebral white matter. The present data suggest that astroglial sclerotic change in various regions of the brain is an important morphological expression of cerebral aging. In view of the lack of other demonstrable histological changes (i.e., silver and amyloid stains were negative) or significant atrophy, the cause of the observed gliosis in BALB/c mice might represent a genuine aging change. As an incidental finding, aggregates of PAS-positive granules were noted in the Ammon's horn of most old animals, while none were seen in the young controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687252
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Lectin histochemistry of plaques and tangles in Alzheimer's disease (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 1-11 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Neuritic plaques ; Amyloid ; Neurofibrillary tangles ; Lectin receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biotinyl derivatives of several lectins and avidin-horseradish peroxidase were used to study the localization of glycoconjugates in amyloid plaques and in neuritic tangles in brains of patients with Alzheimer's disease (AD), Downs syndrome (DS) and Gerstmann-Sträussler syndrome (GSS). The lectins tested recognize the following residues: β-d-galactosyl [Ricinus communis agglutinin 120, (RCA-1) and peanut agglutinin, (PNA)]; α-d-galactosyl [Griffonia simplicifolia agglutinin (GSA)]; α-d-mannosyl〉α-d-glucosyl [concanavalin A (Con A) andLens culinaris agglutinin (LcH)];N-acetyl- andN-glycolylneuraminic acid [Limax flavus agglutinin (LFA) andLimulus polyphemus agglutinin (LPA)];N-acetyl-glucosaminyl and sialyl [wheat germ agglutinin (WGA)];N-acetyl-d-galactosaminyl [Helix pomatia agglutinin (HPA) andDolichos biflorus agglutinin (DBA)] and α-l-fucosyl [Ulex europeus agglutinin (UEA-1)]. The majority of lectins listed above bind preferentially to the peripheral area of AD plaques, whereas in plaques of DS they are mainly bound to central amyloid core. In neurofibrillary tangles of AD brains only residues recognized by WGA and HPA or DBA were found, whereas in DS brains, in addition to above mentioned, β-d-galactose (RCA-1) and sialic acid (LFA) were also present. In brain microblood vessels the strongest reaction in endothelia appeared with UEA-1 and RCA-1, indicating the abundance of α-l-fucosyl and β-d-galactosyl residues. In AD brains deposits of amyloid were noted in the wall of some blood vessels, where monosaccharide residues recognized by RCA-1, GSA, UEA and WGA but not by Con A and LFA were present. However, our studies of some organs (liver, kidney, heart and testes) of patients with generalized amyloidosis revealed a lack of these sugar residues. It indicates, that the composition of amyloid present in brains of AD is different to that in other organs in generalized amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695495
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    Paper (German National Licenses)
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