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  • 1
    Electronic Resource
    Electronic Resource
    Rare association of herpes simplex virus IgM-specific antibodies and Guillain-Barré syndrome successfully treated with plasma exchange and immunosuppression (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 468-474 
    Details
    ISSN: 1432-1440
    Keywords: Guillain-Barré syndrome (GBS) ; Herpes simplex virus (HSV)-IgM antibodies ; Immunohistology ; Plasma exchange ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV) has been associated with various neurological disorders. In contrast, HSV infection is very rarely found in acute polyneuroradiculitis. In this report, a patient is described with a severe course of Guillain-Barré syndrome (GBS). HSV IgM-specific antibodies and a rise of complement-fixation antibodies were detected. During the acute phase of neurologic syndrome, a nerve biopsy showed myelin damage and IgM deposits on the inner layer of the perineurium. Plasma exchange, in combination with immunosuppression, was successfully applied as a treatment in the relapsing course of GBS. Finally, after recovery, HSV-specific IgM antibodies disappeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731495
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  • 2
    Electronic Resource
    Electronic Resource
    Demonstration of antibodies to the surface (anti-p41) and core proteins (anti-p24) of the human immunodeficiency virus (HIV) in individuals positive for anti-HIV (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 596-599 
    Details
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus ; AIDS ; Anti-HIV ; Anti-p41 ; Anti-p24
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diagnosis of infection with the human immunodeficiency virus (HIV) relies on the demonstration of antibody to this virus. Occasionally, the combined analysis of sera using ELISA and western blot reveals false-positive results. We have compared a newly developed test to detect antibodies to the core (anti-p24) and surface (anti-p41) proteins of HIV with the established tests described above. Anti-p24 and anti-p41 were negative in three individuals positive for anti-HIV by ELISA and immunoblot; they had a low risk to acquire HIV infection and were clinically and immunologically normal and suspected false positive previously. In 62 individuals at risk, anti-p41 was always positive while anti-p24 was negative in 24/62 individuals including all but one patient with AIDS. The data indicate that this new test may replace the western blot as a reliable, widely available, and standardized confirmatory assay. In addition, preliminary evidence needs to be confirmed that quantitative analysis of anti-p24 might be of prognostic value in the course of HIV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726665
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  • 3
    Electronic Resource
    Electronic Resource
    A case of sjögren's syndrome with severe anemia due to myelitis (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 92-95 
    Details
    ISSN: 1432-1440
    Keywords: Sjögren's syndrome ; Anemia ; Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual case of Sjögren's syndrome presenting with severe anemia as the predominant clinical feature is described. Histological examination of a bone marrow biopsy specimen demonstrated that the patient's anemia was caused by myelitis and vasculitis of the small intraosseous vessels. Our report might stimulate a more thorough investigation of bone marrow in patients with connective tissue diseases and anemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784137
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 891-891 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737015
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  • 5
    Electronic Resource
    Electronic Resource
    In vivo and in vitro induction of natural killer cells by cloned human tumor necrosis factor (1988)
    Springer
    Cancer immunology immunotherapy 27 (1988), S. 128-132 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The natural killer (NK) cell activity of mice in the peritoneal cavity is very low or undetectable and testing peritoneal NK cells is a useful model for studying the influence of activating substances upon local injection. Injection of tumor necrosis factor (TNF) at doses of 10–200 ng caused a marked activation of NK cell activity which was maximal after 24 h and declined rapidly on day 2. A similar effect was observed when interferons alpha and beta were injected, and there were additive results when interferon was injected together with TNF. The NK cell nature of the effector cells activated by TNF was substantiated by the finding that previous injection with anti-asialo GM 1 antibody prevented activation. Interferon could not be detected in the peritoneal wash fluid after injection of TNF suggesting interferon-independent activation. In further experiments after i.p. injection of TNF peritoneal exudate cells (PECs) only killed YAC-1 targets in a 4-h assay. There was no additional killing in an 18-h assay towards neither YAC-1 cells or P815 cells, suggesting that macrophages were not involved. Furthermore TNF was also active in vitro by activating NK cells in isolated human peripheral blood cells. However in the PECs stimulated in vitro no significant induction of cytotoxic capacities by TNF was measured. Our data suggest that the action of TNF is not restricted to the lysis of tumor cells but can also induce immunological properties in the host defense against virus infections and neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200016
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  • 6
    Electronic Resource
    Electronic Resource
    Sekundärer Immundefekt bei Niereninsuffizienz am Beispiel der Hepatitis B-Impfung (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 865-872 
    Details
    ISSN: 1432-1440
    Keywords: Hepatitis B-vaccination ; Dialysis patients ; Immune deficiency ; Monocyte function ; Hepatitis B-Impfung ; Dialyse-Patienten ; Sekundärer Immundefekt ; Monozytendefekt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die aktive Hepatitis-B-Impfung führt bei Gesunden in über 95%, bei Dialysepatienten nur in ca. 60% zur Bildung protektiver anti-HBs-Antikörper. In vitro geht der Non-Responder-Status mit einer gestörten Monozytenfunktion einher, die eine mangelhafte Interleukin-2-Produktion nach sich zieht. Gleichzeitig findet sich eine vermehrte Expression funktioneller Interleukin-2-Rezeptoren. Exogen zugeführtes Interleukin-2 normalisiert daher bereits in niedriger Dosierung die vorher verminderte proliferative Antwort von Non-Responder-Lymphozyten in vitro. Außerdem läßt sich der Non-Responder-Status von Dialysepatienten in vivo beheben, wenn zur Standard-Impfung mit 40 µg Hepatitis B-Vakzine zusätzlich eine niedrige Interleukin-2-Dosis (2,5 × 105 Einheiten) lokal appliziert wird.
    Notes: Summary In dialysis patients the immune response to hepatitis B-vaccination is greatly impaired. In vitro the non-responders show a failure of the monocytes to support the process of primary T-cell activation. This defect results in a lack of interleukin 2-production and an enhanced sensitivity of the interleukin-2 receptor system. Addition of low doses of interleukin-2 fully reconstitutes the deficient immune response in vitro. Furthermore, the local application of low dose interleukin-2 during a standard vaccination with 40 µg hepatitis B-vaccine normalizes the non-responder state in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728948
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  • 7
    Electronic Resource
    Electronic Resource
    Modification of the immune response against hepatitis B virus by the human immunodeficiency virus (1989)
    Springer
    Rheumatology international 9 (1989), S. 175-179 
    Details
    ISSN: 1437-160X
    Keywords: Hepatitis B virus ; Human immunodeficiency virus ; Interferon alpha ; Chronic hepatitis ; Hepatitis B ; Vaccination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hepatitis B virus and the human immunodeficiency virus are similarly transmitted. Individuals with preexisting HIV infection have a higher chance to become HBsAg carriers than do anti-HIV negative persons. Cytotoxic T cells with specificity for HBcAg, that are under the control of HBcAg-specific helper T cells, are responsible for liver injury. There is good evidence that HIV infection lowers inflammatory activity, is associated with milder liver histology, high levels of viral replication and low seroconversion rates. In addition interferon alpha therapy is less effective in anti-HIV positive subjects. The immune response against HBsAg is helper T-cell dependent and vaccination against hepatitis B is of low effectiveness. In addition, vaccination against hepatitis B may activate the HIV disease and is, therefore, presently not to be recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271876
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