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  • 1
    Electronic Resource
    Electronic Resource
    The structure analysis of Hirano bodies by digital processing on electron micrographs (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 32-37 
    Details
    ISSN: 1432-0533
    Keywords: Hirano body ; Digital processing ; Helical strand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the structure of Hirano bodies, electron micrographs of Hirano bodies taken at various tilting angles have been studied by digital image analysis. On the electron micrographs, the beaded filaments of Hirano bodies were turned into a pattern of lattice-like arrays by changing the tilting angles. Based on computer-procesed diffraction patterns and filtered images, it is proposed that the filaments of Hirano bodies are helical strands with a pitch of 185 Å. A model for the helical strand drawn by microcomputer at various angles of rotation is in accordance with the filtered images of the tilted filaments. Computer simulation also reveals that the helical strands appear to be lattice-like when they are arranged in parallel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687959
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  • 2
    Electronic Resource
    Electronic Resource
    Progressive supranuclear palsy with Lewy bodies (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 344-346 
    Details
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Lewy body ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case is reported which revealed not only clinical and neuropathological features of progressive supranuclear palsy, but also the presence of large numbers of Lewy bodies in the brain stem nuclei and cerebral cortex. This case seems to be progressive supranuclear palsy with Lewy bodies distributed as in Parkinson's disease. Such case has not been previously reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688061
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  • 3
    Electronic Resource
    Electronic Resource
    Lewy bodies are ubiquitinated (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 345-353 
    Details
    ISSN: 1432-0533
    Keywords: Lewy body ; Immunocytochemistry ; Ubiquitin ; Paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The nature of Lewy bodies (LBs) in the brain stem and cerebral cortex in five cases of diffuse Lewy body disease and one case of Parkinson's disease with dementia were investigated immunocytochemically with various antibodies to cytoskeletal proteins, paired helical filaments (PHF) and ubiquitin. Antibodies to 200-kDa component of neurofilament, tau and PHF showed no significant reactions with most of LBs. Antibodies to high-molecular weight microtubule-associated proteins (HMWMAPs) moderately stained the periphery of a few of LBs. A monoclonal antibody to PHF (DF2) which recognizes ubiquitin, and polyclonal antibodies to ubiquitin immunostained virtually all of the typical and cortical LBs as intensely as Alzheimer's neurofibrillary tangles and senile plaque neurites: the periphery of LBs was darkly stained, whereas the central core of typical LBs and central zone of cortical LBs were less intensely stained or remained unstained. Immunoelectron microscopy of the LBs with DF2 revealed that immune reaction products were located on the filaments exclusively in the periphery of LBs, but not on those in the center. These findings suggest that both types of LBs are immunocytochemically indistinguishable despite some structural differences, and that peripherally located filaments in LBs are tagged with ubiquitin, an element required for the ATP-dependent proteolysis system in the cell. Antibodies to ubiquitin are the most useful marker of LBs ever known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687787
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  • 4
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 143-152 
    Details
    ISSN: 1432-0533
    Keywords: Familial amyotrophic lateral sclerosis ; Lewy body-like hyaline inclusion ; Ubiquitin ; Neurofilament
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lewy body-like hyaline inclusion (LI) in the neuronal soma and swollen cord-like processes is a characteristic feature in the anterior horn cells and neurons in thoracic nucleus (Clarke) of familial amyotrophic lateral sclerosis (ALS) with posterior column involvement. We have studied the LI in the case of two sisters with this disorders. Microscopically the LI consists of an eosinophilic “core” surrounded by a basophilic “halo”. Ultrastructurally the core consists of granule-associated filaments, while the halo consists of normal-looking neurofilament. Immunocytochemistry with anti-ubiquitin antibody shows that these granule-associated filaments in the core are highly ubiquitinated, while the normal-looking neurofilaments in the halo are not recognized by antiubiquitin antibody. Our study proves that LI consists of an aggregation of ubiquitinated filaments among a neurofilamentous accumulation, possibly representing a form of neuronal cytoskeletal disorganization in familial ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688202
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  • 5
    Electronic Resource
    Electronic Resource
    Accumulation of amyloid in pituitary adenomas (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 87-92 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary neoplasm ; Anterior pituitary hormone ; Amyloid ; Electron microscopy ; Bromocriptine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accumulation of amyloid in pituitary adenomas was examined in relation to the types of adenoma and the effect of bromocriptine treatment. Amyloid had accumulated in 34 of 48 adenomas (71%). The occurrence in prolactin-secreting adenomas and growth hormone-secreting adenomas was 79%, respectively, while that in non-functioning adenomas was 50%. Treatment with bromocriptine enhanced the occurrence and extent of the amyloid accumulation in prolactin- or growth hormone-secreting adenomas. Electron microscopy revealed the initial appearance of the amyloid fibrils in the smooth endoplasmic reticulum and a possible sequential process of their release from the cells. The presence of secretory granules in vesicles containing amyloid fibrils and their simultaneous release with amyloid fibrils suggested that degradation of secretory granules was involved in the formation of amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688628
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  • 6
    Electronic Resource
    Electronic Resource
    Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3′,5′-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 144-148 
    Details
    ISSN: 1432-0533
    Keywords: Glutathione S-transferase placental type ; T9 glioma cells ; Dibutyryladenosine 3′,5′-cyclic monophosphate ; Allylisothiocyanate ; Benzylisothiocyanate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of dibutyryladenosine 3′,5′-cyclic monophosphate (dibutyryl cAMP) on the expression of glutathione S-transferase placental type (GST-P) was examined in rat glioma cell line using an immunohistochemical technique. Cultured T9 glioma cells were negative for GST-P activity under normal conditions. However, treatment with 1 mM dibutyryl cAMP produced GST-P expression in about 50% of the cells, as well as some morphological changes. The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 μg/ml allyl isothiocyanate (AITC) or 0.1 μg/ml benzyl isothiocyanate (BITC). With these combinated treatments, almost all cultured cells showed a strong positive reaction for GST-P, although AITC or BITC alone elicited GST-P in only 5% of the cultured cells. The results of the present study indicate that dibutyryl cAMP causes functional as well as morphological differentiation of T9 glioma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294371
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  • 7
    Electronic Resource
    Electronic Resource
    Calcifying epithelioma of Malherbe with ossification. Special reference to lectin binding and immunohistochemistry of ossified sites (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 14 (1987), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lectin binding sites and immunohistochemically detectable fibronectin and carbonic anhydrase II (CA II) were examined in induced bone structure of calcifying epithelioma of Malherbe. Pathological features of ossification were particularly evident in the border zone between tumor epithelium and stroma, and epithelial foci adjacent to sites of bone formation were conspicuously basophilic. The use of lectin binding in these foci coincided with the basophilic epithelial zones: Con A, RCA-1, PNA, SBA, and WGA bound strongly, indicating thepresence of glucose (Glu), mannose (Man), galactose (Gal), N-acetyl-D-galactosamine (GalNAC), and N-acetyl-D-glucosamine (GlcNAC). Fibronectin was also detected in the same epithclial-mesenchymal interacting layers as the positive lectin-binding sites. Staining for CA II was strongly positive in giant cells and in epithelial zones in the bone-inducting areas. The bond induction mechanism in the stromal tissue of calicifying epithelioma of Malherbe may initially involve the action CA II in the epithelial-mesenchymal interacting zone, which then brings about ossification of the matrix which is fibronectin-positive and rich in lectin-binding sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1987.tb00494.x
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  • 8
    Electronic Resource
    Electronic Resource
    Wavelength dependence of photorefractive effect in Ti-indiffused LiNbO3 waveguides (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 54 (1989), S. 975-977 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A novel method of measuring the photorefractive sensitivity of Ti-diffused channel waveguides in lithium niobate is proposed and demonstrated. It is suited for quantifying the dependence of the photorefractive sensitivity on the irradiation beam wavelength. From measurements at various irradiation intensities and wavelengths 0.633, 0.81, and 1.06 μm, we give an estimate of the crosstalk of a directional coupler as a function of irradiation intensity and wavelength.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.101421
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  • 9
    Electronic Resource
    Electronic Resource
    New hydride vapor phase epitaxy for GaP growth on Si (1987)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 51 (1987), S. 1245-1247 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Gallium phosphide films are successfully grown on (100) Si substrates by a new hydride vapor phase epitaxy. Mixing of reactant vapors just above the substrate makes the growth rate as high as 50 nm/min even in the temperature range of 350–450 °C. This makes the two-step growth procedure applicable for growing a single domain GaP film on Si from H2-HCl-PH3-Ga reactants. An etch pit density of 7.5×106 cm−2 and a full width at half-maximum of 93 arcsec in a double-crystal x-ray rocking curve are achieved. Green light-emitting diodes with 565 nm peak wavelength are successfully fabricated using nitrogen-doped GaP films grown on Si.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.98693
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  • 10
    Electronic Resource
    Electronic Resource
    Malignant lymphoma presenting as initial symptom in the uterus. Case report (1988)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 95 (1988), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1988.tb06799.x
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