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  • 1
    ISSN: 1432-1440
    Keywords: Immunoadsorption ; Protein A ; Immunosuppressive serum factors ; Colorectal cancer ; Mixed lymphocyte culture ; Lymphocyte proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum factors may be responsible for reduced host-anti-tumor defence. Although there is still confusion about their origin, attempts have been made to immobilize serum components by Protein A columns as a therapeutic modality. In our study the in vitro adsorption of 90% of the IgG from cancer sera on “immobilized protein A” did not influence the inhibitory serum activity as measured in a mixed lymphocyte culture. Therefore, IgG or immune complexes do not seem to be the suppressive serum factor in patients with advanced colorectal carcinoma. There is evidence for leakage of small amounts of protein A from the columns which have immunostimulatory activity. Perhaps this may explain necrosis after a therapeutic immunoadsorption.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: LDL apheresis ; Vitamin E ; Vitamin A ; α-Tocopherol ; Retinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum α-tocopherol and retinol concentrations were followed in four heterozygous adults and one homozygous child with familial hypercholesterolemia being treated by regular low-density lipoprotein (LDL) apheresis. Approximately 50% of plasma α-tocopherol was eliminated during a single apheresis procedure in the heterozygous adults, while a complete elimination of this vitamin along with LDLs was observed in the homozygous child. Absolute losses of α-tocopherol amounted to 13.4–22.5 mg/apheresis and are equivalent to the recommended dietary intake for 1.5 to 2 days. Despite these losses, no changes were observed either in serum α-tocopherol levels or in the ratio of α-tocopherol/total serum lipids after 12 months regular apheresis treatment. Serum retinol concentrations only showed a small decrease on apheresis, there being apparently no specific elimination of this vitamin. The absolute losses ranged from 42–422 µg/apheresis and were, therefore, much lower than the recommended dietary intake of the equivalent of 1500 µg retinol/day. It is concluded that no extra supplementation of these vitamins is required during LDL-apheresis therapy, although it may be advisable to monitor vitamin E status in patients on long-term, intensive therapy.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-2451
    Keywords: Spleen ; Autologous replantation ; Milz ; Autologe Replantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 41 Patienten, bei denen wegen einer traumatischen Milzruptur eine Splenektomie (n = 21) oder eine autologe Replantation von Milzgewebe (n = 20) durchgeführt worden war, stellten sich einer Nachuntersuchung.Ergebnisse: 1. Nach autologer Replantation läßt sich Milzgewebe szintigraphisch nachweisen. z. Bei der traumatischen Milzruptur ist die Splenosisincidenz sehr hoch. 3. Replantiertes Milzgewebe und Splenosis gewährleisten eine ausreichende Clearancefunktion. 4. Durch den Wegfall der Speicherfunktion der Milz erklärt sich eine Erhöhung der B-Lymphocyten und T-Suppressorzellen im peripheren Blut. 5. Die Replantation von Milzgewebe ist eine Alternative zur Milzerhaltung bei schweren Milzverletzungen.
    Notes: Summary A follow-up examination was performed on 41 patients who had had a traumatic rupture of the spleen (autologous replantation,n = 20; splenectomy,n = 21). In all replantation cases spleen tissue was demonstrated scintigraphically. After traumatic ruptures of the spleen, the incidence of splenosis was very high. There was good clearance function in all replantation and splenosis cases. The lack of the spleen's storage function is responsible for elevated B-lymphocyte and T-suppressor-cell levels in peripheral blood. In severe traumatic ruptures, the replantation of splenic tissue is an alternative procedure for preserving the spleen.
    Type of Medium: Electronic Resource
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