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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 4970-4977 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present the design of the high-voltage (30 MV) Applied-B ion diode that is now being tested on the PBFA-II accelerator at Sandia National Laboratories. This diode design is the first application of a new set of numerical design tools that have been developed over the past several years. Furthermore, this design represents significant departures from previous designs due to much higher voltage and the use of a nonprotonic ion, Li+. The higher voltage increases the magnetic field strength required to insulate the diode from 1 to 2 T of previous diodes to 3–7 T. This represents a very large increase in the magnetic field energy and the magnetic forces exerted on the field-coil structures. Our new design incorporates changes in the field-coil locations to significantly reduce the field energy and the forces on the field-coil structures. The use of nonprotonic ions introduces a new complication in that these ions will be stripped when they penetrate material, i.e., the gas cell membrane. The importance of current neutralization, charge-exchange reactions, and the conservation of canonical angular momentum are discussed in the context of designing light ion diodes suitable as drivers for inertial confinement fusion. We have simulated the performance of this diode design using the electromagnetic particle-in-cell code, magic. We find that the most sensitive point in the power flow is the transition from the self-magnetically insulated transmission line to the applied field region of the diode.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A series of experiments was performed with an Applied-B ion diode on the Particle Beam Fusion Accelerator-I, with peak voltage, current, and power of approximately 1.8 MV, 6 MA, and 6 TW, respectively. The purpose of these experiments was to explore issues of scaling of Applied-B diode operation from the sub-TW level on single module accelerators to the multi-TW level on a low impedance, self-magnetically insulated, multimodule accelerator. This is an essential step in the development of the 100-TW level light ion beam driver required for inertial confinement fusion. The accelerator and the diode are viewed as a whole because the power pulse delivered by the 36 imperfectly synchronized magnetically insulated transmission lines to the single diode affects module addition, diode operation, and ion beam focusability. We studied electrical coupling between the accelerator and the diode, power flow symmetry, the ionic composition of the beam, and the focusability of the proton component of the beam. Scaling of the diode impedance behavior and beam quality with electrical drive power is obtained from comparison with lower-power experiments.The diode impedance lifetime was about 10 ns, several times shorter than for lower-power experiments. Azimuthal and top-to-bottom variations of the diode and ion currents were found to be approximately ±10%, compared with an estimated requirement of 5%–7% uniformity to avoid focal blurring by self-magnetic field effects. The ion production efficiency was 80%–90%. However, only 50%±10% of the ion current was carried by protons; the balance was carried by multiply charged carbon and oxygen ions. Activation measurements showed a proton beam energy of approximately 50 kJ. A gas cell filled with 5 Torr of argon was used for beam transport. The macroscopic divergence was 15±10 mrad and the microscopic divergence was 20±15 mrad, values that are similar to those from lower-power experiments. A model of beam focusing is formulated that predicts the proton charge focused onto 0.47-cm radius lithium targets, taking into account beam purity, magnetic bending, small-angle multiple scattering, and intrinsic divergence. The model results and activation measurements of the number of protons focused onto targets agree, and indicate that the spatially averaged (over about 3 cm2) peak focal power was about 0.5 TW/cm.2 The most important limitations on power concentration were found to be the low proton content of the beam, the short impedance lifetime of the diode, and the asymmetric current feed of the accelerator. The short impedance lifetime limited the power coupled to the diode, and caused the voltage at peak ion power to be low, which exacerbates the small-angle scattering problem. The asymmetric feed caused focal blurring through nonuniform self-magnetic bending. At least partly because of the experience gained with low impedance beams during these experiments, the next generation accelerator, the 100-TW Particle Beam Fusion Accelerator-II, has been configured to produce a 25–30-MV Li+ beam rather than a 5-MV proton beam. off
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 59 (1986), S. 11-18 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Fully electromagnetic particle-in-cell simulations of Applied-B ion diodes have been performed using the magic code. These calculations indicate that Applied-B diodes can be nearly 100% efficient. Furthermore, the simulations exhibit an impedance relaxation phenomenon due to the buildup of electron space charge near the anode which causes a time-dependent enhancement of the ion emission above the Child–Langmuir value. This phenomenon may at least partially explain the rapidly decreasing impedance that has been observed in Applied-B ion diode experiments. The results of our numerical simulations will be compared to experimental data on Applied-B ion diodes and to analytic theories of their operation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1440
    Keywords: LDL apheresis ; Vitamin E ; Vitamin A ; α-Tocopherol ; Retinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum α-tocopherol and retinol concentrations were followed in four heterozygous adults and one homozygous child with familial hypercholesterolemia being treated by regular low-density lipoprotein (LDL) apheresis. Approximately 50% of plasma α-tocopherol was eliminated during a single apheresis procedure in the heterozygous adults, while a complete elimination of this vitamin along with LDLs was observed in the homozygous child. Absolute losses of α-tocopherol amounted to 13.4–22.5 mg/apheresis and are equivalent to the recommended dietary intake for 1.5 to 2 days. Despite these losses, no changes were observed either in serum α-tocopherol levels or in the ratio of α-tocopherol/total serum lipids after 12 months regular apheresis treatment. Serum retinol concentrations only showed a small decrease on apheresis, there being apparently no specific elimination of this vitamin. The absolute losses ranged from 42–422 µg/apheresis and were, therefore, much lower than the recommended dietary intake of the equivalent of 1500 µg retinol/day. It is concluded that no extra supplementation of these vitamins is required during LDL-apheresis therapy, although it may be advisable to monitor vitamin E status in patients on long-term, intensive therapy.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Hypercholesterolemia ; Low-density lipoproteins ; Heparin precipitation ; Extracorporeal plasma treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The first clinical application of a new extracorporeal procedure (HELP) for the selective elimination of low-density lipoproteins by heparin precipitation at acid pH is described. Plasma, obtained by filtration of whole blood through a 0.2 µ filter, is continuously mixed with an equal volume of an acetate buffer (pH 4.85) containing heparin. After removal of the precipitated heparin complex by filtration, excess heparin is adsorbed to a specially developed filter and the clear plasma filtrate is subject to bicarbonate dialysis/ultrafiltration to restore physiologic pH and remove excess fluid. The calculated efficiency for the elimination of low-density lipoproteins from plasma by HELP is 100% and is therefore comparable to conventional plasmapheresis. The HELP system shows a high degree of specificity with over 80% of total protein being returned to the patient. Over 130 treatment procedures have now been performed. Patient compliance and acceptance have been excellent and no major complications have been observed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 1003-1012 
    ISSN: 1432-1440
    Keywords: Concentration of serum magnesium ; CK activity ; Myocardial infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum magnesium concentrations were followed during the course of coronary infarction and were correlated to the event on the basis of the creatinine kinase activity E.C. no. 2.7.3.2. Those patients admitted to the hospital at a very early stage of the infarction showed initial high serum magnesium concentrations which fell during the event to subnormal values and then normalized later. In the case of severe coronary infarction (maximum CK activity 〉 700 U/l) the subsequent decrease in serum magnesium concentration was more pronounced than in subjects with lower CK activity. Patients suffering from angina pectoris had normal serum magnesium values which did not show any concentration change during a clinical follow-up. The previously postulated correlation between low serum magnesium and high risk for myocardial infarction may be questioned in the light of our observations.
    Type of Medium: Electronic Resource
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  • 8
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 36:10 (1988) 894 
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 187 (1987), S. 359-367 
    ISSN: 1433-8580
    Keywords: Nifedipine ; Atherosclerosis ; Regression ; Hypercholesterolemia ; Rabbits ; Aortic cholesterol ; Platelet half-life time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nifedipine has been implicated as an inhibitor of dietary induced atherosclerosis in rabbits. This study was designed to examine the effect of nifedipine on the regression of atherosclerotic lesions in this animal model. NZ-rabbits were fed a cholesterol-enriched diet (1.5%) for 4.8 months. A control group A was killed and the aorta removed for planimetry of the vessel wall lesions. The remaining animals were divided into two groups, group P receiving a placebo solution and group N a nifedipine solution (2 × 20 mg/day). They were maintained on a standard chow for a further 4.5 months. In the nifedipine-treated group N, sudanophilia of the aorta was reduced by more than 20% as compared to the cholesterol-fed control group A and was 50% lower than in the placebo-treated group. Total cholesterol of the aortic tissue was lowest in group N. No significant differences in plasma cholesterol, triglycerides or the platelet half-life time were observed between the placebo- and the nifedipine-treated group. These data indicate that nifedipine can stimulate regression of pre-existing atherosclerotic lesions in rabbits.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1920
    Keywords: MRJ ; MS ; Follow up ; Drug therapie ; Cortisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty patients with relapsing/remitting course of MS were studied four times with MR imaging over the course of one year. First MR was undertaken during the acute relapse, afterwards patients were given cortisone therapy for four to six weeks. The second MR study followed 4–6 weeks after the first, the patients at this time being in remission. The third MR study was carried out 4 months after the first, the last scan one year after the first. The total number of lesions varied, though not greatly, over the whole follow-up, but there was an influence of the clinical course of MS on the pattern of lesions in MR imaging, mostly in respect to the number of confluences and the size of the lesions. Follow-up over one year showed that the inflammatory process produced an increase in the number of plaques, independent of the fact that most patients stayed in remission. A delayed effect of the cortisone therapy on the size, number, and confluence of plaques is suggested whilst clinical signs improved in most cases immediately after the beginning of drug therapy. Independent of the clinical course of the disease in some cases plaques previously seen vanished and others appeared in one and the same examination.
    Type of Medium: Electronic Resource
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