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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of morphogenetic mutants of hydra (1981)
    Springer
    Development genes and evolution 190 (1981), S. 191-196 
    Details
    ISSN: 1432-041X
    Keywords: Morphogenetic mutants ; Hydra ; Head regeneration ; Morphogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The mutantreg-16 is deficient in head regeneration and abnormal in size regulation. The gastric region becomes twice as long as that of normal animals before the first bud is produced. Both mutant characteristics are due to changes in head-specific morphogen concentrations.Reg-16 contains twice as much head inhibitor and only half as much head activator in its head as normal animals. This leads to a higher level of free head inhibitor in the whole animal resulting on one hand in a greater distance of buds from the head, and on the other hand in a total blockage of release of head activator and head inhibitor which would be necessary to initiate head regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848302
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Properties of the foot inhibitor from hydra (1980)
    Springer
    Development genes and evolution 188 (1980), S. 133-139 
    Details
    ISSN: 1432-041X
    Keywords: Hydra ; Morphogenetic substances ; Regeneration ; Pattern formation ; Sea anemones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A substance was isolated from crude extracts of hydra that inhibits foot regeneration. This substance, the foot inhibitor, has a molecular weight of ≦500 daltons. It is a hydrophilic molecule, slightly basic in character and it has no peptide bonds. The pruified substance acts specifically and at concentrations lower than 10−7 M. At this low concentration only foot and not head regeneration is inhibited. Hydra are sensitive to purified foot inhibitor between the second and eight hour after initiation of foot regeneration by cutting. In normal animals the foot inhibitor is most likely produced by nerve cells. A substance with similar biological and physico-chemical properties is found in other coelenterates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848805
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The head and the foot inhibitor from hydra are not dowex artefacts (1984)
    Springer
    Development genes and evolution 193 (1984), S. 117-118 
    Details
    ISSN: 1432-041X
    Keywords: Hydra ; Regeneration ; Head inhibitor ; Foot inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In a recent publication in this journal (Berking 1983) it was claimed (1) that the head inhibitor we isolated from hydra is a Dowex artefact, (2) that a separate foot inhibitor does not exist in hydra and (3) that the only inhibitor that has so far been isolated from hydra is one which inhibits head and foot regeneration equally well. These statements are incorrect and require a response. In the following, I would like to summarise our evidence that the inhibitors isolated from hydra, including Berking's inhibitor, have different specificities for head and foot regeneration. In addition, I would like to show that none of our substances are Dowex artefacts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848640
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  • 4
    Electronic Resource
    Electronic Resource
    HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP) (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 29 (2002), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/Aim:  There is growing indication that differences in host response determine susceptibility and resistance to periodontal disease. Particularly, the effect of histocompatibility antigens (HLA) on early onset periodontitis (EOP) has been studied. As most of the results are not conclusive and to date no report has been done on German patients, the aim of this study was to investigate the distribution of HLA alleles in a group of 50 German RPP patients and 102 German AP patients and to compare them to 102 control probands without periodontitis.Methods:  Diagnosis was established according to standardised clinical criteria. HLA typing was performed using serologic and molecular biologic (PCR-SSP) techniques.Results: Compared to the controls, RPP patients had a significantly higher frequency of HLA-DRB1*13 and a significantly lower frequency of HLA-DRBblank*(non-DRB3/4/5). AP patients showed a significantly increased occurrence of HLA-B*14 and -Cw*08 as well as a significantly decreased frequency of HLA-A*03. In both patient groups HLA-A*11 and -A*29 had an increased frequency and HLA-A*31 and -A*30/31 were decreased. These differences were statistical significant in the whole patient group (RPP + AP).Conclusions:  Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051X.2002.290614.x
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  • 5
    Electronic Resource
    Electronic Resource
    The three sorCS genes are differentially expressed and regulated by synaptic activity (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 88 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have isolated the murine sorCS3 gene, a new member of the family of receptors containing a Vps10p-domain. Receptors of this family facilitate rapid endocytosis and are thought to be involved in intracellular sorting. SorCS3 and the highly homologous sorCS1 and sorCS2 genes were expressed in a combinatorial, mostly non-overlapping pattern in both the developing and mature central nervous system. During development, distribution and abundancy of their transcripts was regulated. Moreover, their expression was differentially influenced by neuronal activity in the hippocampus of adult mice. Although kainic acid-induced seizures had no effect on sorCS2 mRNA levels, they dramatically increased the expression of sorCS1 and sorCS3. The activity-dependent induction of sorCS1 expression required de novo protein synthesis, whereas that of sorCS3 did not. Our results imply that the three sorCS genes have diverse, but partly overlapping functions in the developing and mature central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2004.02286.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of different luting procedures on the seating of ceramic inlays (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This in vitro study evaluated the effect of different luting procedures on the proper seating of ceramic inlays and on the marginal seal through microleakage testing. Sixty mesial-, occlusal-, distal- (MOD) cavities were prepared in third molars, and distributed among four groups. In the control group 1, the cavity surface was treated with dentin and enamel bonding agents; ceramic inlays were placed into the cavity and light cured. In group 2, the dentin and enamel bonding agents were cured prior to the placing of the inlays, and following the insertion. In group 3, the inlays were luted without enamel bonding. In group 4, the inlays were cemented using a one-bottle bonding and two times light curing. The groups with only one time light curing at the end of the luting process exhibited the smallest luting space following cementation. The smallest dye penetration values were obtained for the two groups with separate light curing of the dentin bonding agent. Reducing the film thickness of polymerized dentin bonding agents, i.e. by changing the composition of the bonding agents, could facilitate proper seating of ceramic inlays together with a better marginal seal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2000.00525.x
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  • 7
    Electronic Resource
    Electronic Resource
    Tensile bond strengths of four different dentin adhesives on irradiated and non-irradiated human dentin in vitro (2001)
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 28 (2001), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study evaluated the influence of irradiation on dentin bond strength. Sixty irradiated and 60 non-irradiated human third molars were used. The irradiation dose of 60 Gy was fractionally applied over 6 weeks (2 Gy day−1, 5 days week−1). All teeth were prepared in a special manner allowing the simulation of intra-pulpal pressure and dentin perfusion. Dentin specimens with a thickness of 2·0 mm were obtained under standardized conditions. The specimens were randomly assigned to four experimental groups. Tensile bond strength of four different dentin bonding agents (Scotchbond™ 1, Solobond Plus®, Prime&Bond™ 2·1 and Syntac®) was evaluated using an Instron Universal testing machine. Pairwise comparison did not show any significant differences between the irradiated and non-irradiated groups. The influence of the different dentin adhesives was significant (P=0·0001; ANOVA). Compared with Solobond Plus® and Prime&Bond™ 2·1, the use of Scotchbond™ 1 resulted in a significantly higher tensile bond strength in non-irradiated specimen (P〈 0·05; closed test procedure based on Kruskal–Wallis test). Within the limitations of an in vitro study, it can be concluded that adhesive restoration procedures can be successfully used in patients irradiated for cancer of the head and neck.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2001.00758.x
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  • 8
    Electronic Resource
    Electronic Resource
    Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans (1981)
    [s.l.] : Nature Publishing Group
    Nature 293 (1981), S. 579-580 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Head activator, as assayed by its biological effect on hydra, was found in brain and intestine of cow, pig, rat and human5'6. The hypothalamus of an adult rat contained 105 hydra equivalents, the intestine 10 times more. Cow and pig contained comparable amounts per animal. The best source was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/293579a0
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  • 9
    Electronic Resource
    Electronic Resource
    Epithelial cells in nerve-free hydra produce morphogenetic substances (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 589-591 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In a preliminary investigation we have shown that severely nerve-depleted hydra, which consist almost exclusively of epithelial cells, contain normal concentrations of morphogenetic substances7. To exclude the possibility that the few remaining nerve cells overproduce these substances, we have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283589a0
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  • 10
    Electronic Resource
    Electronic Resource
    Morphogene substanzen ausHydra (1981)
    Springer
    Naturwissenschaften 68 (1981), S. 252-256 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract We use hydra as a model system to understand how growth and differentiation and, as a consequence of this, pattern formation are controlled at the molecular level. We have found that four substances control head and foot formation in hydra: an activator and an inhibitor of head formation and an activator and an inhibitor of foot formation. The two activators are peptides with molecular weights around 1000 daltons, the inhibitors are smaller in molecular weight (〈500), have an overall positive charge and do not contain peptide bonds. In normal animals all four substances are present and most likely produced by nerve cells. We hope to understand how these substances act and interact to create the spatial and temporal pattern of growth and differentiation typical for hydra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01047327
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