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  • 1
    Digitale Medien
    Digitale Medien
    Resonance Raman characterization of highly reduced iron octaethylporphyrin: [Fe(OEP)]n- (n = 0, 1, and 2) (1987)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 180-184 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja00235a028
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  • 2
    Digitale Medien
    Digitale Medien
    Immunohistochemical study of carbonic anhydrase in mixed tumours and adenomas of sweat and sebaceous glands (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 14 (1987), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Immunohistochemical distribution of carbonic anhydrase II (CA) in mixed tumours and adenomas of sweat gland origin and in sebaceous adenomas was demonstrated by the PAP method. Normal sweat glands, both eccrine and apocrine, clear cells of the secretory coils, and ductal epithelial cells all showed conspicuous staining for CA, and sebaceous glands were also positive. Mixed tumours of the skin indicated strongly positive staining for CA in the luminal cells of tubular and duct-like or cystic structures, while most of the other tumour cells were negative. In solid or massive foci, CA positive cells were found scattered among the cellular mass. Sebaceous adenomas were usually moderately positive for CA throughout the tumour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0560.1987.tb00501.x
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  • 3
    Digitale Medien
    Digitale Medien
    Immunohistochemical localization by monoclonal antibody of human epidermal growth factor in mixed tumours of the skin (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 14 (1987), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Immunohistochemical distribution of human epidermal growth factor (hEGF) was described in 17 cases of mixed tumour of the skin with monoclonal antibody. In normal sweat glands, epithelial cells in the secretory portion and in the transitional area between secretory portion and duct showed prominent staining for hEGF. In the salivary pleomorphic adenoma type of mixed tumour of the skin, luminal tumour cells of tubular and duct-like structures gave a very characteristic hEGF staining reaction. The tumour cells showing strong staining for hEGF were scattered throughout the solid foci in this type of mixed tumour. Tubular epithelial cells in the clear cell adenoma type also displayed a positive hEGF reaction. And apocrine mixed tumours strong staining for hEGF occurred on the apical side of tubular and ductal tumour cells. In view of the immunohistochemical staining patterns for hEGF, the histologic origin of mixed tumours of the skin is suggested to be cells in the secretory portion and (hose in the transitional portion between secretory portion and duct of the sweat gland.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0560.1987.tb01534.x
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  • 4
    Digitale Medien
    Digitale Medien
    Immunohistochemical localization of keratin in experimental carcinoma of the mouse submandibular gland (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: An immunohistochemical survey of the distribution of keratin was studied in chemically induced carcinomas of the submandibular glands of mice. Initial signs of premalignant changes were degranulation of granular convoluted tubule cells and deposition of keratin protein in small limited areas of the degranulated cells. There was a gradual increase in the area showing keratin staining in altered tubule cells. Duct-like and cystic structures stained intensely for keratin, as did squamous metaplastic epithelial cells. Induced carcinomas were variably keratinized. Basal layers of cells of squamous-cell carcinomas displayed weak keratin staining, and spinous tumor cells and parakeratotic tumor cells showed somewhat increased levels of keratin staining. Some desquamated keratotic tumor cells stained intensely for keratin. Just as the localization of epidermal and nerve growth factors and lectin-binding histochemistry have been used in studying tumorigenesis in the mouse submandibular gland, immunohistochemically detected keratin proved to be a useful marker of tumor cells of ductal segment origin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00556.x
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  • 5
    Digitale Medien
    Digitale Medien
    Lectin histochemistry of submandibular glands following duct-ligation in mice and rats (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 14 (1985), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Lectin binding patterns of Con A. PNA, SHA, DBA, WGA, RCA-1 and UEA-1 were tarried out in duct-ligated submandibular glands (SMGs) of rats that diplayed acute degenerating changes Lectin staining was also related to histologic changes. Proliferating epithelial cells which were probably derived from intercalated duet cells showed a strong SBA and WGA staining on the 3rd day. Duct-like and cystic structures appeared on the 7th day and staining by PNA, SBA. WGA. RCA-1 and Con A was described In mice. lectin binding after duct ligation appeared similar to the rat In the long-term observation of mice SMGs. acinar cell regeneration occurred between the 2lsl and 42nd days and they stained strongly for DBA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1985.tb00553.x
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  • 6
    Digitale Medien
    Digitale Medien
    Histochemical observations of lectin-binding in experimental carcinomas in mouse submandibular glands (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Peroxidase-conjugated lectins were used for the histochemical detection of carbohydrates in experimental carcinomas of mouse submandibular glands. Induced carcinomas, 43 lesions from 25 cases, were examined histoehemically with galactose-binding leetins (PNA and RCA-I), N-acetyl-galactosamine-binding leetins (DBA and SBA), a fucosc-binding lectin(UEA-l), and a N-acetyl-glucosamine-binding lectin (WGA). In non- or slightly keratinized squamous-cell carcinomas, the lectin binding of PNA, RCA-1, DBA, SBA. and WGA was weak in tumor epithelia, and UEA-1 binding was slight. In highly keratinized squamous-cell carcinomas, lectin binding was increased in tumor epithelia, but no reaction was noted in completely keratinized regions. Desquamated materials in lumens of tumors gave an intense stain with leetins. Stromal connective tissue, including collagen fibers and basement membranes stained intensely. Lectin binding to submandibular carcinomas was different from binding to granular convoluted tubules and the striated ducts of the normal submandibular gland.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01460.x
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  • 7
    Digitale Medien
    Digitale Medien
    Studies on saliva in ODU plaque-susceptible rats having experimental gingivitis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 19 (1984), S. 0 
    Details
    ISSN: 1600-0765
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Saliva was collected from the submandibular, parotid, and sublingual glands at to compare the amount of saliva between ODU plaque-susceptible (Sus) and plaque-resistant (Res) rats. The amount of saliva secreted was less in the Sus rats than in the Res rats. This difference was mainly due to a decrease in salivation from the submandibular glands, which resulted from the decrease in the weight of these glands. This reduction in salivation may be associated with the rapid rate of plaque formation seen around the mandibular teeth of these animals and the development of periodontal diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0765.1984.tb01192.x
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  • 8
    Digitale Medien
    Digitale Medien
    Ameloblastic fibroma: growth potentiality of odontogenic epithelium and coexpression of intermediate filament proteins in fibromatous cells (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Four cases of ameloblastic fibroma are described immunohistochemically in terms of intermediate-sized proteins in both epithelial and mesodermal components. Keratin proteins were demonstrated by polyclonal anti-keratin antiserum (TK: detecting 41–65 kDa keratins) and 2 monoclonal antibodies to keratin (KL1: 55–57 kDa, PKK1: 44, 46, 52 and 54 kDa), and monoclonal antibodies to vimentin and desmin. Two types of odontogenic epithelial tumour cells were discriminated: undifferentiated odontogenic cells and common ameloblastoma cells. Keratin expression was found to be stronger in undifferentiated cells than in the ameloblastoma cells. Undifferentiated cells were PAS–positive, while ameloblastoma cells were negative. Fibroma cells were strongly positive for vimentin, and negative for desmin. Keratin proteins were also expressed slightly. Thus, coexpression of keratin and vimentin was seen in fibroma cells. Histogenesis is discussed from the standpoint of the distribution patterns of keratin and vimentin, as well as with respect to the histopathology.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1988.tb01519.x
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  • 9
    Digitale Medien
    Digitale Medien
    Monoclonal antibody-detected vimentin distribution in pleomorphic adenomas of salivary glands (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: To evaluate the participation of myoepithelial components in pleomorphic adenomas, an immunohistochemical study was carried out using monoclonal antibodies to vimentin. Of a total of 80 cases, 50 tumors gave positive staining, 5 tumors very slight, and 25 tumors negative staining for vimentin. Localization patterns for vimentin were divided into 3 classes: 1) vimentin staining in fibrous stromal tissue; 2) variable intensities of vimentin staining were found in the outer layers of tumor cells in tubuloductal structures (some of which were spindle cells connected to modified myoepithelial cells which also gave variable vimentin staining); and 3) modified myoepithelial cells and chondroidlike cells displayed strongly positive staining for vimentin. Typical histologic features of pleomorphic ademomas, i.e., tubulo-ductal or duct-like structures were characterized by positive vimentin staining in outer tumor cells and by a positive keratin reaction in the luminal tumor cells. In tumors devoid of stromal connective tissues and the near absence of well-developed, or modified myoepithelial cells, vimentin staining was absent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1988.tb01548.x
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  • 10
    Digitale Medien
    Digitale Medien
    Immunohistochemical observations on carbonic anhydrase I and II in human salivary glands and submandibular obstructive adenitis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract Immunohistochemical identification of carbonic anhydrase I and II (CA-I, CA-II) was made in human major salivary glands and obstructive adenitis in submandibular glands. Normal salivary glands stained the strongest for CA-II in serous acinar cells and were negative in mucous cells. Moderate to strong staining for CA-I and CA-II was found in ductal segments. Submandibular glands with obstructive adenitis exhibited reduced CA-1 activity in atrophic acinar cells, but not in ductal elements in the early and intermediate stages of the disorder. In the late stage of the obstructive lesion, CA staining in duct-like structures was moderate; however, almost degenerate ductal cells were negative for CA. During the progression of the degeneration in the obstructive lesion, the CA staining decreased dependent on acinar atrophy. Even after longstanding obstruction of the salivary gland, altered ductal epithelia may retain some of their functions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00604.x
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