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  • 1
    Electronic Resource
    Electronic Resource
    Nucleated blood cells both bind and internalize insulin (1983)
    Springer
    Diabetologia 24 (1983), S. 69-70 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275951
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of post-prandial insulin release by ingested opiate-like substances in dogs (1983)
    Springer
    Diabetologia 24 (1983), S. 113-116 
    Details
    ISSN: 1432-0428
    Keywords: β-Casomorphin ; enkephalin ; naloxone ; insulin release ; exorphins ; opiates ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously demonstrated that opiate-like substances in food protein (exorphins), contained in the peptic digest of gluten, stimulate insulin and glucagon release in dogs and that this effect is inhibited by the opiate antagonist naloxone. The present study was designed to evaluate the possible rôle of ingested opiate-like substances in the modulation of post-prandial insulin release. Similarly, the addition of synthetic β-casomorphins, which are the opioid-active material of bovine casein peptone, elicit a stimulation of post-prandial insulin release during a liver extract-sucrose test meal. The addition of met-enkephalin to a liver extract-sucrose test meal also augmented the post-prandial insulin response. Both stimulatory effects were reversed by oral naloxone, as was the post-prandial increase of insulin following ingestion of bovine casein peptone (casopeptone). The post-prandial insulin response to digested and undigested liver extract was not affected by naloxone, suggesting that the foregoing effects are likely to be specific to opiate-like materials contained in foodstuff (exorphins). In view of previous findings, the present data are compatible with a role of opiate-like substances contained in ingested nutrients in the regulation of post-prandial insulin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297392
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of synthetic rat C-peptide in normal and diabetic rats (1983)
    Springer
    Diabetologia 25 (1983), S. 288-290 
    Details
    ISSN: 1432-0428
    Keywords: C-peptide ; insulin secretion ; effect of insulin ; alloxan-diabetic rats ; C-peptide effect in vivo ; somatostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of synthetic rat C-peptide 1 and C-peptide 2 on plasma insulin and blood glucose concentrations in the rat were studied. Infusion of rat C-peptide (500μg·h-1· kg-1) diminished glucose induced increase of plasma insulin by 56% (15.2±0.9 versus 6.6± 0.6 ng/ml, p〈0.01, mean±SEM). Somatostatin infused at a rate of 50 μg·h-1·kg-1 body weight inhibited glucose-induced insulin secretion by 33%. In the presence of a mixture of both C-peptides or somatostatin, blood glucose after intravenous glucose was higher than in the control experiments. In alloxan-diabetic rats, C-peptide (160 μg/kg) significantly increased and prolonged the hypoglycaemic effect of exogenous insulin. It is suggested that C-peptide may not be a biologically inert substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279945
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  • 4
    Electronic Resource
    Electronic Resource
    Book reviews (1980)
    Springer
    Diabetologia 19 (1980), S. 406-408 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280531
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Report of the Third Workshop of the EASD Study Group on Artificial Insulin Delivery Systems, Pancreas and Islet Transplantation (AIDSPIT) (1984)
    Springer
    Diabetologia 27 (1984), S. 607-608 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276979
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Somatostatinoma syndrome. Clinical, morphological and metabolic features and therapeutic aspects (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 681-689 
    Details
    ISSN: 1432-1440
    Keywords: Somatostatin ; Insulin ; C-peptide ; Diabetes ; Pituitary function ; Gastric acid secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of somatostatinoma syndrome in a 30-year-old woman is presented. Basal levels of growth hormone and of pancreatic and gastric hormones were reduced and the response of growth hormone, insulin and C-peptide to stimuli such as arginine, glucose, glibenclamide and calcium was virtually abolished. Similarly, gastric acid secretion, pancreatic exocrine function and intestinal absorption were significantly reduced. On the other hand, basal and stimulated levels of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) were within the normal range. Plasma somatostatin-like immunoreactivity was increased to 600 2,000 pg/ml (normal: 88–140 pg/ml). Immunocytochemical studies demonstrated the presence of somatostatin immunoreactive material in the primary tumour in the head of the pancreas and in the liver metastases. In spite of two courses of chemotherapy with streptozotocin and 5-fluorouracil the patient died due to liver failure 5 months after the first admission to hospital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487613
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  • 7
    Electronic Resource
    Electronic Resource
    Die T3-Hyperthyreose unter den Aspekten der Sekretion und peripheren Produktion der Schilddrüsenhormone (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 495-500 
    Details
    ISSN: 1432-1440
    Keywords: T3-hyperthyroidism ; Endogenous labelling of T4 and T3 ; T4-deiodination ; T3-production ; r-T3-formation ; T3-Hyperthyreose ; Endogene Markierung von T4 und T3 ; T4-Dejodination ; T3-Produktion ; r-T3-Bildung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der T3-Hyperthyreose ist im Vergleich zu der T4/T3-Hyperthyreose nur das T3 erhöht, während das T4 und das r-T3 im Normbereich liegen. Die endogene Markierung des T4 ist auch bei der T3-Hyperthyreose erhöht, so daß eine vermehrte T4-Sekretion angenommen werden muß. Die normalen T4-Konzentrationen dürften aus einer verstärkten T4-Dejodination resultieren. Als Ursache für das hohe T3 bei gleichzeitig normalem r-T3 wird eine Richtungsumkehr der Dejodination des T4 zum T3 zu ungunsten des r-T3 diskutiert.
    Notes: Summary In contrast to T4/T3-hyperthyroidism, where T4, T3, and r-T3 serum concentrations (SC) are elevated, in T3-hyperthyroidism the T3-SC alone is increased, whereas T4-SC is normal and r-T3 may be decreased. Endogenous labelling of T4 with131I is increased in T3-hyperthyroidism similarly as in T4/T3-hyperthyroidism, clearly reflecting an increased thyroidal formation of T4 in T3-hyperthyroidism. The contradiction of a normal SC of T4 in the presence of enhanced thyroidal formation of T4 may be explained by increased peripheral T4-deiodination. Since in T3-hyperthyroidism T3-SC are elevated whereas r-T3-SC are decreased, there is good evidence for a shift in T4 conversion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696211
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  • 8
    Electronic Resource
    Electronic Resource
    Importance of early postprandial insulin delivery in insulin-dependent diabetics (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 738-744 
    Details
    ISSN: 1432-1440
    Keywords: Insulin infusion ; Artificial endocrine pancreas ; Glucose-controlled insulin infusion system ; Insulin therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In nine insulin-dependent diabetics postprandial glucose control under closed loop insulin infusion by an artificial endocrine pancreas was compared with that obtained under open loop infusion employing identical infusion profiles which were advanced 20 min by time in the case of open loop infusion. The earlier increase of insulin infusion rates in the latter case resulted in lower postprandial glucose concentrations during the first 90 min after meal intake. Incremental areas under the blood glucose curves during this time were significantly lower when insulin infusion rates rose earlier (4.5×103±0.5×103 vs 2.1×103±0.6×103 mg/dl×min;p〈0.02). Insulin was administered at maximum rates 45–50 min after the start of the meal during closed loop infusion (196±38 mU/min) and 25–30 min after the meal during open loop infusion (192±35 mU/min). Correspondingly, mean free insulin concentrations which are available from six patients rose to 135±47 (40 min) or 141±50 µU/ml (20 min). Glucagon levels did not differ between both parts of the study. It is concluded that increases of post-prandial insulin infusion rates occurring earlier than increases of blood glucose levels are important for optimizing glucose profiles and possibly reflect physiologic conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725708
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Semisynthetic human insulin and purified pork insulin do not differ in their biological potency (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 1145-1150 
    Details
    ISSN: 1432-1440
    Keywords: Semisynthetic human insulin ; Biological potency ; Insulin hypoglycaemia ; Euglycaemic clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The biological potency of semisynthetic human insulin (Actrapid HM, Novo) and purified pork insulin (Actrapid MC, Novo) was assessed in normal and diabetic subjects. The blood glucose lowering effect and the related counter-regulatory response were initially tested in six healthy subjects who received an i.v. injection of 0.15 U/kg body weight of either insulin preparation. The attained insulin levels were very similar (peak at 15 min: HM 139±7, MC 129±7 µU/ml), as well as the resulting blood glucose curves. A prolonged suppression of C-peptide values was observed after injecting both preparations. The evoked counter-regulatory response [glucagon, growth hormone (GH), cortisol and catecholamines] showed minimal differences. Prolactin secretion was almost identical after HM and MC injection. A glucose clamp study was subsequently performed in six insulin-dependent diabetic (IDD) patients. Blood glucose levels were maintained at 80 mg/dl by the artificial pancreas during a 180 min infusion of MC or HM insulin (30 mU/kg/h). The amounts of dextrose infused during the last 60 min of the study were not significantly different (121±14 vs 137±11 mg/kg/h for MC and HM, respectively). It is clear from our results that at the dose levels used in this study, the biological potency of i.v. injected HM is very similar to that of MC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712180
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Impaired blood pressure response to norepinephrine in a case of insulin-dependent diabetes mellitus — Improvement with a β-adrenergic antagonist (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 366-370 
    Details
    ISSN: 1432-1440
    Keywords: Diabetic neuropathy ; Adrenergic receptors ; Orthostatic hypotension ; β-Blocking agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of juvenile-onset insulin-dependent diabetes mellitus in a 30-year-old male patient is reported. He was admitted to the hospital because of severe diabetic neuropathy, predominantly in the lower extremities. Signs of autonomic neuropathy were not evident but the patient had severe orthostatic hypotension. Circulating catecholamine concentrations were normal; however, the blood pressure response to infused norepinephrine was reduced ten-fold compared to a group of normals. An improvement of the blood pressure response to sympathomimetic drugs was accomplished during the simultaneous administration of propranolol, a β-receptor blocking agent. The present data suggest a possible defect of the adrenergic receptor system in response to sympathomimetic drugs while the release of catecholamines and the function of the parasympathetic nervous system appears to be intact. Treatment with β-blocking agents such as propranolol as an adjunct to sympathomimetics seems to be a promising approach which might deserve further consideration in similar cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716256
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