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  • 1
    Electronic Resource
    Electronic Resource
    Benign fibrous histiocytoma of bone (1981)
    Springer
    Journal of cancer research and clinical oncology 101 (1981), S. 191-202 
    Details
    ISSN: 1432-1335
    Keywords: Bone tumor ; Fibrous histiocytoma ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Case report of a patient with an unusual, rapidly growing bone tumor in the third and fourth cervical vertebrae. Histological and electron-microscopic investigations reveal a tumor composed of histiocytic cells, xanthomatous cells, giant cells of Touton type, and fibroblastic cells. No cellular features of malignancy are observed. From its cytologic appearance the tumor has to be classified as a benign fibrous histiocytoma. Regarding its ultrastructural features, the tumor may not be distinguished from non-ossifying fibroma of bone, but its clinical pattern shows obvious differences of localization and growth potential. The term “benign fibrous histiocytoma of bone” is proposed for these tumors which must be differentiated from non-ossifying fibroma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413313
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  • 2
    Electronic Resource
    Electronic Resource
    Biologic characterization of human bone tumors I. Ewing's sarcoma (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 171-180 
    Details
    ISSN: 1432-1335
    Keywords: Ewing's sarcoma ; Type IV collagen ; Factor-VIII-associated protein ; Endothelial differentiation ; Electron microscopy ; Immunofluorescence microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six cases of Ewing's sarcoma were investigated by electron and immunofluorescence microscopy. A layer of basement membrane-like deposits was found between typical principal and secondary tumor cells. To clarify the nature of these ultrastructural deposits, antibodies against collagen type IV were applied to frozen sections of corresponding tumor tissue. This reaction revealed type IV collagen as a regular component of basement membranes in nonneoplastic tumor capillaries, but it was equally able to localize collagen type IV between single tumor cells in capillary-free areas. With the same method, factor-VIII-associated protein, predominantly found in endothelial cells, could be demonstrated in some tumor cells. These results demonstrate that, in addition to anaplastic cells, some tumor cells are found in Ewing's sarcoma that share certain differentiating features with the endothelial cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402065
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  • 3
    Electronic Resource
    Electronic Resource
    Biologic characterization of human bone tumors (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 234-239 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Collagen types ; Immunofluorescence microscopy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen cases of typical highly malignant osteosarcoma were investigated by light, electron, and immunofluorescence microscopy to demonstrate the presence of collagen types I–III. It was shown that, in light-microscopically anaplastic areas of the tumor, collagen type III predominates, while only very few membranes of collagen type I are observed. Ultrastructurally, the cells are characterized by numerous free ribosomes in their cytoplasm and only a few membranes of granular endoplasmic reticulum (ER). In osteoblastic areas, collagen type I is increased, while type-III collagen is decreased. The cytoplasm of cells contains markedly more granular ER. An increasing mineralization of matrix is observed. In fibroblastic areas of the tumors, collagen types I and III are codistributed. Tumor cells have a fibroblast appearance with elongated nuclei and well developed granular ER. The chondroblastic areas, characterized by immature neoplastic cartilage, contain varying amounts of collagen type II. Chondroblast-like tumor cells have typical ring-shaped membranes of granular ER in their cytoplasm. The evidence of different collagen types in osteosarcomas lends additional support to the concept that a pluripotent mesenchymal cell is the stem cell of osteosarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402614
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  • 4
    Electronic Resource
    Electronic Resource
    Combined ultrastructural, histochemical, and autoradiographic study of osteosarcoma after preoperative chemotherapy according to the COSS 80 protocol (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 25-31 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Chemotherapy ; Electronmicroscopy ; Histochemistry ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve osteosarcomas treated according to the COSS 80 protocol (preoperative chemotherapy, resection) were studied by light and electron microscopic, histochemical, and autoradiographic methods. Evidence of regressive and necrotic changes was found in many tumor cells, but the alterations were unspecific. Viable tumor cells of high malignancy were also observed regularly, often at the S phase. As the tumor regression continued, a strong reaction of the mononuclear phagocyte system was manifested by the presence of macrophages and giant cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625048
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  • 5
    Electronic Resource
    Electronic Resource
    Homologous genes for X-linked chondrodysplasia punctata in man and mouse (1983)
    Springer
    Human genetics 〈Berlin〉 63 (1983), S. 24-27 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary X-linked dominant chondrodysplasia punctata is a human gene defect characterized by punctate foci of epiphyseal calcification, cataracts, ichthyosis, and systematized atrophoderma. In a comparative study, the murine X-linked mutant ‘bare patches’ was found to display strikingly similar skeletal, ocular, and cutancous anomalies. The human as well as the murine phenotypes occur exclusively in the female sex, apparently because the underlying mutations are lethal for male embryos. In both traits, the cutaneous lesions are arranged in a linear and blotchy pattern reflecting lyonization. The observed similarities constitute strong evidence that the two genes are homologous. The proposed homology is a further example of the evolutionary conservatism of the X-chromosome in mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285392
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  • 6
    Electronic Resource
    Electronic Resource
    The submicroscopic structure of a chondroblastic osteogenic sarcoma (1984)
    Springer
    Archives of orthopaedic and trauma surgery 103 (1984), S. 100-106 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden zwei Fälle vom typischen chondroiden Osteosarkom, deren Struktur auch submikroskopisch analysiert wurde, beschrieben. Das klinische und radiologische Bild, sowie der schnelle letale Verlauf der Erkrankung unterstützten die Diagnose eines Osteosarkoms. Dagegen zeigten die histologische und elektronenmikroskopische Untersuchung einen überwiegenden Anteil vom malignen Chondroid. Der Fortschritt in den Behandlungsmethoden des Osteosarkoms zeigt aus diagnostischen, therapeutischen und prognostischen Gründen die Wiedereinführung der Subklassifikation der Osteosarkome, sowie die Korrelation ihres morphologischen Bildes mit ihren biologischen Eigenschaften, als unentbehrlich. Nach den derzeitigen Erfahrungen vermindert die chondroblastische Komponente in keinem Fall die schnelle maligne Penetranz eines Osteosarkoms. Es ist grundsätzlich wichtig, diese Tumoren von den meist weniger malignen Chondrosarkomen zu unterscheiden, auch wenn das maligne Chondroid in diesen Osteosarkomen überwiegt. Danach muß auch die Therapie entsprechend radikal und kombiniert durchgeführt werden.
    Notes: Summary Two patients are reported with a chondroid form of osteosarcoma, whose structure was also analyzed submicroscopically. The clinical and radiologic picture and the rapid lethal progress of the disease indicated an osteosarcoma, while both histologic and electron-microscopic investigation suggested the prevalence of malignant chondroid. Progress in the treatment of osteosarcoma makes it essential for diagnostic, therapeutic and prognostic reasons to reintroduce subclassification of these tumors in an attempt to correlate their morphological picture with their biologic properties. According to our experience to date, it seems that the cartilaginous component in no way ameliorates the rapid malignant penetration of the osteosarcoma. It is essential to distinguish these tumors from the usually much less malignant chondrosarcomas and to place the chondroblastic osteogenic sarcoma among in spite of the clear predominance of the malignant chondroid, and thus also introduce highly radical and combined therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389580
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  • 7
    Electronic Resource
    Electronic Resource
    Closure of osteochondral lesions using chondral fragments and fibrin adhesive (1983)
    Springer
    Archives of orthopaedic and trauma surgery 101 (1983), S. 213-217 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 75 Kniegelenken von 46 ausgewachsenen Kaninchen wurden Knorpelknochendefekte gesetzt, die einen Durchmesser von 4 mm batten und den subchondralen Spongiosaraum eröffneten. Dreiundzwanzig Defekte wurden offengelassen oder mit Kollagenschaum oder Fibrinkleber oder einer Kombination der beiden letztgenannten Substanzen verschlossen. Zweiundünfzig Defekte wurden mit Pfröpfen aus feinstverteiltem autologem Gelenkknorpel und einem eigens angefertigten Fibrinkleber verschlossen, größtenteil unter Zusatz von Kollagenschaum zur Blutstillung. In den erstgenannten Defekten wurden auch nach 40wöchiger Überlebenszeit nur bindegewebige Regenerate gefunden, nie hyaliner Knorpel. In den mit autologem Knorpel und Fibrinkleber gefüllten Defekten wurde eine lebhafte Chondrozytenvermehrung beobachtet mit Ausbildung eines Hyalinknorpels, der morphologisch und auch in seiner Fähigkeit zur enchondralen Ossifikation dem juvenilen Knorpel entspricht und durch Alcianblau anfärbbare Mucopolysaccharide enthält. Nach Neubildung des subcondralen Knochens wandelt sich das histologische Bild dann zur Erscheinung des adulten Gelenkknorpels. Erklärt wird dieser Vorgang durch eine zweite Adoleszenz des adulten Knorpels, da diesem durch das reiche Substrat- und Sauerstoffangebot aus den Markraumgefäßen ein Milieu geschaffen wird, welches demjenigen vor Ausbildung des subchondralen Knochens bei Wachstumsabschluß gleicht. Es konnten mit diesem Verfahren vollständige hyalinknorpelige Defektverschlüsse erzielt wurden, deren Oberfläche im Niveau der Umgebung liegt.
    Notes: Summary In 75 knee joints of 46 adult rabbits osteochondral defects of 4 mm diameter were placed by a drill reaching the cancellous bone. Twenty-three defects were left untreated, or closed by collagen foam or fibrin adhesive, or a combination of both. Fifty-two defects were closed with very small autologous cartilage fragments and a special fibrin adhesive. The adhesive differed from commercially supplied types by adigested alpha chain of fibrinogen for increase in concentration, and by the addition of alpha-2-macroglobuline as protease-inhibitor. In most cases small pieces of collagen foam were added for hemostasis. In the first group of 23 joints observed over up to 40 weeks, no hyaline cartilage was found histologically in any of the defects. In the second group a rapid proliferation of chondrocytes appeared with development of hyaline cartilage with alcianblue-positive matrix. It resembled juvenile cartilage in its histologic appearance and with regard to the induction of ossification. The phenomenon is interpreted as a “second adolescence” of the adult cartilage induced by the rich nutritional and oxygen supply from the cancellous vessels, which resembles the environmental conditions before the forming of subchondral cortical bone at the end of the growth period. This method enabled us to achieve a complete closure of defects by hyaline cartilage on the very level of the surrounding articular surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436773
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