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  • 1
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen (1976)
    Springer
    Archives of microbiology 107 (1976), S. 143-160 
    Details
    ISSN: 1432-072X
    Keywords: New nucleoside-peptide antibiotic ; Chitin biosynthesis ; Structure elucidation ; Mass spectrometry ; Streptomyces tendae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Der Streptomycet Tü 901, Streptomyces tendae, bildet ein antifungisch wirkendes Nukleosid-Antibioticum, Nikkomycin. Als Angriffsort kommt die Chitinsynthese in Frage. Mit Hilfe der Massenspektrometrie und des chemischen Abbaus konnten Uracil, eine Aminohexuronsäure und eine neue, einen Pyridinring enthaltende Aminosäure nachgewiesen werden.
    Notes: Abstract From the fermentation broth of Streptomyces tendae Tü 901 a substance was isolated, which inhibits the growth of several fungi. The new antibiotic affects the chitchin biosynthesis. Its structure was identified by mass spectrometry of the products obtained after chemical degradation. Nikkomycin is a nucleoside-peptide antibiotic consisting of uracil, an amino hexuronic acid and a new amino acid containing a pyridin ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446834
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  • 2
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen (1976)
    Springer
    Archives of microbiology 107 (1976), S. 249-256 
    Details
    ISSN: 1432-072X
    Keywords: Antibiotic derivatisation ; Yeast antibiotic ; Tryptanthrin ; Tryptophan metabolism ; Candia lipolytica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Candida lipolytica synthetisiert das Antibioticum Tryptanthrin aus 1 Mol Tryptophan und 1 Mol Anthranilsäure. Bei Verfütterung von Tryptophan und substituierter Anthranilsäure, bzw. substituiertem Tryptophan und Anthranilsäure, konnten die zu erwartenden Tryptanthrinderivate isoliert und identifiziert werden. Die Enzyme der Tryptanthrinbiosynthese wiesen in bezug auf diese Substrate, mit Ausnahme von Bromtryptophan, keine Spezifität auf. Parallel zu diesen Versuchen wurden durch chemische Synthese substituierte Tryptanthrine hergestellt. Die Dierivate wurden auf ihre antibiotische Wirksamkeit geprüft; als besonders wirksam erwiesen sich die halogenierten Verbindungen.
    Notes: Abstract Candida lipolytica synthesizes the antibiotic tryptanthrin from 1 mole tryptophan and 1 mole anthranilic acid. When feeding tryptophan and substituted anthranilic acids, or substituted tryptophans and anthranilic acid, we could isolate and identify the expected derivatives of tryptanthrin. The enzymes of the biosynthesis of tryptanthrin, with the exception of bromotryptophan, had no specifity for these substrates. In addition to these experiments substituted tryptanthrines were chemically synthesized. We checked them for antibiotic action; the halogen compounds turned out to be especially effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425335
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  • 3
    Electronic Resource
    Electronic Resource
    Mikrowellenhyperthermie und Onkolyse durch Clostridien (1975)
    Springer
    Naturwissenschaften 62 (1975), S. 541-542 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609084
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  • 4
    Electronic Resource
    Electronic Resource
    Far-infrared absorption of the superionic conductor Li3N. temperature and isotope effects (1979)
    Springer
    The European physical journal 32 (1979), S. 375-378 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The far-infrared absorption spectrum (20–250cm−1) of the superionic conductor Li3N —with6Li- and7Li-isotopes in the starting material—has been measured for different polarizations and temperatures (4–150 K). TheE ⊥c spectrum yields two lines near 80 and 140 cm−1, which are not observed forE ⊥c. From the isotopic frequency ratio (ω 6/ω 7≃1.07) and from the comparison to lattice dynamics it is concluded that these lines are due to resonant modes, weakly coupled to the lattice. Measurements of the isotope effects on the dielectric properties (10 Hz to 1 MHz) establish that the local diffusive type motion in shallow potentials and the low lying resonant modes originate from the same defect system (including Li-ions in non-regular positions).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02109466
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  • 5
    Electronic Resource
    Electronic Resource
    Histamin in der Interstitialflüssigkeit der befallenen und klinisch nicht befallenen Haut bei chronisch rezidivierender Urticaria (1979)
    Springer
    Archives of dermatological research 266 (1979), S. 269-276 
    Details
    ISSN: 1432-069X
    Keywords: Chronic urticaria ; Histamine ; Interstitial fluid ; Histamine determination with autoanalyzer technique ; Chronisch rezidivierende Urticaria ; Histamin ; Interstitialflüssigkeit ; Histamin-Bestimmung mit Autoanalyzer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 8 Patienten mit idiopathischer chronisch rezidivierender Urticaria wurden in der Periumbilicalregion Saugblasen gleichzeitig auf frischen urticariellen Herden und der unveränderten Haut daneben produziert und Histamin in der Blasenflüssigkeit bestimmt. Hierzu wurde die von Siraganian entwickelte Methode der Autoanalyzer-Technik in modifizierter Form verwendet. Die Histaminspiegel lagen bei diesen Patienten in unveränderter Haut in derselben Größenordnung wie bei 10 Normalpersonen, während alle 8 Urticaria-Patienten höhere Histamin-Werte in den Urticae verglichen mit der nicht befallenen Haut aufwiesen; bei 4 der Patienten waren diese Unterschiede jedoch nur gering ausgeprägt.
    Notes: Summary In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60–120 min. The blister fluid histamine was determined with a modified autoanalyzer technique developed by Siraganian. In this method the extraction of histamine, the condensation of o-phthaldialdehyde with histamine and the measurement of the fluorochrome is automated. With the described method it is possible to measure values less than 0.5 ng/ml. Histamine levels in perilesional skin were nearly in the same range as in the periumbilical skin of 10 normal persons. The range of the normal tissue fluid histamine levels was 0–15 ng/ml and they did not differ significantly from the plasma levels. In all 8 patients with chronic urticaria the histamine values were higher in lesional than in perilesional skin. In 1 patient the lesional blister fluid histamine value reached 35.5 ng/ml. Four of the patients showed only low differences (less than 3 ng/ml).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418572
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  • 6
    Electronic Resource
    Electronic Resource
    Zum Mechanismus der gas-chromatographischen Trennung enantiomerer Aminosäurederivate (1976)
    Springer
    Chromatographia 9 (1976), S. 331-332 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Trennung enantiomerer Aminosäurederivate an chiralen stationären Phasen wird bisher weitgehend auf die Ausbildung unterschiedlich stabiler Wasserstoffbrücken-Assoziate zwischen stationärer Phase und den darin gelösten Enantiomeren zurückgeführt. Die Trennung von D- und L-Aminosäuren an einer stationären Phase, die keine Wasserstoffbrückenbindung zwischen den beteiligten Partnern zuläßt, beweist, daß andere Wechselwirkungskräfte als Wasserstoffbrückenbindungen für die Enantiomerentrennung verantwortlich zu machen sind.
    Notes: Summary The separation of enantiomeric amino acid derivatives on chiral stationary phases is believed to be predominantly due to the formation of hydrogen bond complexes between the stationary phase and the, enantiomeric solutes. The separation of D-and L-amino acids on a stationary phase which does not allow the formation of hydrogen bonds between solvent and solutes indicates that interactions other than hydrogen bonding are responsible for enantiomeric separations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268837
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  • 7
    Electronic Resource
    Electronic Resource
    Gas-chromatographische Trennung von diastereomeren Aminosäureestern an chiralen stationären Phasen (1976)
    Springer
    Chromatographia 9 (1976), S. 72-73 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine quantitative Analyse des Razemisierungsgrades von Aminosäuren durch gas-chromatographische Trennung der diastereomeren Aminosäureester an nicht-chiralen stationären Phasen ist ungenau, wenn optisch unreine Reagentien zur Herstellung der Derivate Verwendung finden. Dieses Problem kann durch den Einsatz chiraler stationärer Phasen, an denen alle optischen Isomeren getrennt werden, überwunden werden.
    Notes: Summary A quantitative analysis of racemic amino acids by gas chromatographic separation of diastereoisomeric esters on non-chiral stationary phases is inaccurate when optically impure reagents are used for the formation of derivatives. This problem can be solved by using a chiral stationary phase, on which all optical isomers are separated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269222
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  • 8
    Electronic Resource
    Electronic Resource
    Gas chroamtographic separation of optically active compounds in glass capillaries (1977)
    Springer
    Chromatographia 10 (1977), S. 444-448 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Chiral compounds may be separated by gas chromatography by direct enantiomer separation on optically active stationary phases. More generally the separation can be achieved on conventional stationary phases after formation of diastereoisomeric derivatives. In this work we report on new results in enantiomer separation, indicating that hydrogen bond association is not the only kind of molecular interaction responsible for enantiomer separation. For the separation of a wide variety of chiral compounds with amino or hydroxy groups diastereo-isomeric derivatives may be formed by reaction with L-α-chlorisovaleryl chloride. The derivatives of amino acids, aliphatic and aromatic amines, amino alcohols and of some alcohols are separated in glass capillaries. Gas chromatography as a separation technique of high selectivity is specifically useful for the separation of mixtures of chemically related components with comparable molecular interactions with the molecules of the stationary phase of a gas chromatographic column. The separation of optically active compounds, particularly, requires highly efficient columns. Glass capillary chromatography is a tool that meets this standard and was applied exclusively in this work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257358
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  • 9
    Electronic Resource
    Electronic Resource
    Mass spectrometric investigation of peptide amides (1976)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 3 (1976), S. 241-244 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction products of trifluoroacetic anhydride with peptide amides are identified as stable heterocyclic imidazolin-5(4)-ones, which can be analysed by gas chromatography mass spectrometry. The mass spectra show intense molecular ions and allow the assignment of the amino acid sequence.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200030510
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  • 10
    Electronic Resource
    Electronic Resource
    GC/MS investigations of the constituents in a diethyl ether extract of an acidified roast coffee infusion (1978)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 1 (1978), S. 69-71 
    Details
    ISSN: 0935-6304
    Keywords: Gas Chromatography Mass Spectrometry ; Capillary, glass/Varian, MAT 311A ; Separation and detection (El, Cl) of some roast coffee constituents ; Three new phenolic compounds found ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A roast coffee infusion (nicaragua arabica) was acidified (pH 1,5) with hydrochloric acid and extracted with diethyl ether in a perforator. After evaporation of the solvent the residue was treated with N-methyl-N-trimethylsilyl trifluoroacetamide and analyzed by glass capillary GC/MS. The main components were identified by their electron impact and isobutane chemical ionization mass spectra. 1,2,4-trihydroxy benzene, 1-ethyl-3, 4-dihydroxy benzene and 2,3-dihydroxy toluene were identified as new constituents of roast coffee with possible emetic properties.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240010114
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