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  • 1
    Electronic Resource
    Electronic Resource
    Quantitation of secondary ion mass spectrometric images by microphotodensitometry and digital image processing (1977)
    s.l. : American Chemical Society
    Analytical chemistry 49 (1977), S. 2322-2329 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50022a052
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multielement atomic spectrometry with a computerized vidicon detector (1976)
    s.l. : American Chemical Society
    Analytical chemistry 48 (1976), S. 505-510 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60367a007
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhomogeneity of surface labelling of B-cells at prospective sites of exocytosis (1979)
    Springer
    Diabetologia 16 (1979), S. 135-138 
    Details
    ISSN: 1432-0428
    Keywords: Membrane ; cell coat ; lectin-binding sites ; exocytosis ; cell web ; B-cell ; islet of Langerhans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using ferritin-labelledRicinus communis agglutinin to detect lectin-binding sites of the pancreatic B-cell surface, we show that limited regions of the plasma membrane are deprived of lectin-binding sites over marginated secretory granules. Such deprived regions increased during glucose stimulation of B-cells in monolayer culture: 56±8 of them were found in high (300 mg/100 ml) glucose as compared to only 27±5 in low (50 mg/100ml) glucose (p〈0.005). In addition, non-membrane, intracytoplasmic bridges were detected between the plasma membrane and the membrane of the marginated granule suggesting the involvement of cell web components in promoting the change in surface labelling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01225464
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Tandem Genetic Duplications in Phage and Bacteria (1977)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 31 (1977), S. 473-505 
    Details
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.mi.31.100177.002353
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    EVIDENCE FOR A SINGLE CATALYTIC BINDING SITE ON HUMAN BRAIN TYPE B MONOAMINE OXIDASE (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The tricyclic antidepressant drug, amitriptyline, inhibited the B form of human brain mitochondria] monomine oxidase (MAO) under normal atmospheric conditions in a noncompetitive manner when phenylethylamine (PEA) was used as substrate and competitively when benzylamine (BzNH2) was employed as substrate. In addition, it was also found that PEA and BzNH2 inhibited each other's degradation noncompetitively. Similar results have previously been reported with human platelet MAO. These data suggest that the catalytic binding sites for PEA and BzNH2 on the B form of human brain MAO may be different. Attempts were made to further distinguish these catalytic binding sites on the brain oxidase using the irreversible MAO inhibitors, pargyline and clorgyline. Though these drugs have considerably different affinities for the B form of the oxidase, the degree to which either compound inhibited PEA or BzNH2 deamination was essentially identical. When incubations were performed at elevated oxygen concentrations PEA and BzNH2 became mutually competitive inhibitors of each other's metabolism. Also at the higher levels of oxygen, amitriptyline inhibition of PEA deamination approached a competitive fashion. These results suggest that PEA and BzNH2 share a common catalytic binding site on the B form of MAO and, in addition, bind to an inhibitory site on the reduced form of the oxidase. Accordingly, the data indicate that amitriptyline also binds to both the oxidized and reduced forms of this human brain oxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb00316.x
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  • 6
    Electronic Resource
    Electronic Resource
    Studies of lymphocyte stimulation to tumor-associated antigen (1979)
    Springer
    Cancer immunology immunotherapy 7 (1979), S. 25-29 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Extracts of both fresh tumor and tissue culture cells propagated from these tumors were compared in a lymphocyte stimulation assay. Tissue culture lines were grown in media containing 20% fetal calf serum (FCS) and in serum-free chemically defined medium. Melanoma-associated antigens were extracted by means of 3 M KCl. Melanoma-associated antigens from two tissue culture cell lines stimulated 3H-thymidine (3H-Tdr) incorporation in lymphocytes from 7 of 17 melanoma patients, whereas no stimulation was noted in response to extracts of isologous fresh surgical specimens. The antigen solubilized from tissue culture cells demonstrated tumor-associated specificity. Stimulated 3H-Tdr incorporation was noted in lymphocytes from 17 of 38 melanoma patients, 2 of 18 patients with other cancers, and 3 of 18 normal subjects. Extracts from both FCS-grown-and chemically defined medium-grown cells were stimulatory. Fetal calf serum was detected in extracts of FCS-grown cells by complement fixation, but was not present in stimulatory concentrations. IgG antibody was detected by immunodiffusion in the nonstimulatory extract of fresh tumor, but was not detected in the stimulatory tissue culture extracts or extracts of normal tissues from the same patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205406
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  • 7
    Electronic Resource
    Electronic Resource
    Studies of lymphocyte stimulation to tumor-associated antigen (1979)
    Springer
    Cancer immunology immunotherapy 7 (1979), S. 19-23 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lymphocyte stimulation to 3 M KCl extracts of fresh human tumors was studied by measuring the incorporation of 3H-labeled protein and nucleic acid precursors. Lymphocytes from cancer patients and normal donors were incubated with autologous and allogeneic extracts. Duplicate lymphocyte cultures were labeled with 3H-leucine (3H-Leu), 3H-uridine (3H-Udr), or 3H-thymidine (3H-Tdr). All patients were sensitized to keyhole limpet hemocyanin (KLH) prior to testing. Of the 29 cancer patients tested, many demonstrated significant uptake of 3H-Udr (90%) and 3H-Leu (62%), but not 3H-Tdr (7%) in response to soluble tumor extracts. However, most patients demonstrated uptake of all three precursors in response to KLH. Lymphocytes from cancer patients did not undergo morphologic blast cell transformation in the presence of tumor extracts. Significant incorporation of 3H-Leu and 3H-Udr was seen after 24–48 h of incubation, while significant 3H-Tdr incorporation was not detected until day 5. Stimulation by KLH was significantly greater for all isotope precursors than stimulation in response to tumor extracts. Responses of lymphocytes from normal donors to tumor extracts were noted, although they occurred less frequently than in lymphocytes from cancer patients. Lymphocytes from cancer patients incorporated 3H-Leu and 3H-Udr, but only rarely incorporated 3H-Tdr in response to 3 M KCl extracts of fresh tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205405
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  • 8
    Electronic Resource
    Electronic Resource
    Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 504-509 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Insulin binding to its receptor leads to negatively cooperative interactions among the receptor sites. Studies with 29 insulin analogues (animal insulins and proinsulin, insulin-like growth factor and chemically modified insulins) which vary 1,000-fold in their affinity for the receptor and in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/273504a0
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Electron microscopic demonstration of cell surface carbohydrates by means of peroxidase and ferritin complexes of the Lens culinaris lection (1975)
    Springer
    Histochemistry and cell biology 43 (1975), S. 275-282 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The use of Lens culinaris lectin for electron microscopic detection of D-mannose, D-glucose and N-acetyl-D-glucosamine like sites on tumor cells, erythrocytes, erythrocyte ghosts, cultured rat liver cells and various tissues of mice is demonstrated. In addition to Lens culinaris lectin-peroxidase reaction (LcL-po reaction) the preparation of active Lens culinaris lectin-ferritin conjugate are described and the specificity of cytochemical reactions are demonstrated. Furthermore experiments by immuno freeze-etching are reported for topological analysis of the lectin receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499709
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  • 10
    Electronic Resource
    Electronic Resource
    A contribution to the formation mechanism of calcium oxalate urinary calculi (1979)
    Springer
    Urological research 7 (1979), S. 223-226 
    Details
    ISSN: 1434-0879
    Keywords: Urolithiasis ; Calcium oxalate ; Intrarenal crystallisation ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbits were given glyoxylic acid to induce intrarenal calcium oxalate crystal formation. The point of crystallisation in the renal tubule, the structure and the composition of the intrarenal crystals were studied. The initial crystallisation takes place in the proximal tubule. Calcium phosphate formation was excluded by microprobe examination. The comparison of the structures of the intrarenally formed crystals with those of Whewellite stones by scanning electron microscopy and the examination of isolated crystals by x-ray diffraction showed the intratubular crystals to consist of Whewellite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257209
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