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  • 1
    Electronic Resource
    Electronic Resource
    Cytochemical and biochemical demonstration of an alkaline phosphatase in human red cells (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 763-764 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Erythrocyten und Erythroblasten von drei Mitgliedern einer Familie mit Polyglobulie wurde alkalische Phosphatase nachgewiesen. Die stärkste Aktivität fand sich in den Erythroblasten des Knochenmarkes.K m -Wert und elektrophoretische Wanderungsgeschwindigkeit des extrahierten Erythrocytenenzyms in Gelen unterscheiden sich von den Werten der alkalischen Neutrophilenphosphatase. Zumindest ein Teil des Enzyms ist an die Erythrocytenmembran oder das Erythrocytenstroma gebunden.
    Notes: Summary Activity of alkaline phosphatase has been demonstrated in the red cells of three members of a family with erythrocytosis. The highest activity is found in the cytoplasm of erythroblasts in bone marrow.K m value and migration velocity of the extracted erythrocyte enzyme in gels differ from that of leukocyte alkaline phosphatase. At last part of the enzyme is bound to red cell membrane or stroma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497139
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  • 2
    Electronic Resource
    Electronic Resource
    Cytochemischer Nachweis von β-Glucuronidase und β-Acetylglucosaminidase bei Plasmocytom (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 480-482 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The activities ofβ-glucuronidase andβ-acetylglucosaminidase have been demonstrated in the plasma cells of 17 patients with multiple myeloma and of 30 patients with normal plasma cells or reactive plasmacytosis by cytochemical methods. In all cases of multiple myeloma the activity ofβ-glucuronidase was elevated as compared with non-neoplastic plasma cells, activity ofβ-acetylglucosaminidase showed a slight to strong elevation in 13 out of 15 patients with multiple myeloma, a normal activity was seen in 2 patients. 10 cases of multiple myeloma were investigated with both methods: in 6 there was stronger activity ofβ-glucuronidase, in 1 patientβ-acetylglucosaminidase showed the stronger reaction, in 3 cases both enzymes revealed the same pattern. These results support the view that neoplastic plasma cells contain a high degree of lysosomal enzymes.
    Notes: Zusammenfassung In den Plasmazellen von 17 Patienten mit Plasmocytom und 30 Patienten mit normaler Plasmazellzahl oder reaktiver Plasmocytose, die als Vergleich dienten, wurdenβ-Glucuronidase undβ-Acetylglucosaminidase mit cytochemischer Methodik bestimmt. Bei allen untersuchten Fällen von Plasmocytom war dieβ-Glucuronidaseaktivität im Vergleich zu den Kontrollfällen deutlich gesteigert, dieβ-Acetylglucosaminidaseaktivität war bei 13 von 15 untersuchten Patienten gering bis stark erhöht, bei 2 Patienten im Vergleich zu den Kontrollfällen nicht sicher verändert. In 6 von 10 parallel mit beiden Methoden untersuchten Plasmocytomen war dieβ-Glucuronidaseaktivität stärker, in 1 Fall dieβ-Acetylglucosaminidase, bei 3 Fällen waren die Resultate identisch. Die Ergebnisse stützen die früher geäußerte Ansicht, daß neoplastische Plasmazellen reichlich lysosomale Enzyme besitzen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485098
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  • 3
    Electronic Resource
    Electronic Resource
    Chronische myeloische Leukämie mit Philadelphia-Chromosom und Tandem-Translokation am 2. Chromosom Nr. 22; 46, XX, tan (22 q+; 22 q−) (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 123-126 
    Details
    ISSN: 1432-1440
    Keywords: Chromosome aberrations ; chronic granulocytic leukemia ; philadelphia-chromosome ; tandem-translocation (22; 22) ; photometric measurements ; Chromosomenaberrationen ; chronische Myelose ; Philadelphia-Chromosom ; Tandem-Translokation (22; 22) ; Densitometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einer 56jährigen Frau mit chronischmyeloischer Leukämie fand sich im peripheren Blut ein einheitlicher Karyotyp mit einem Philadelphia-Chromosom, dessen fehlendes Stück an die langen Arme des 2. Chromosoms Nr. 22 transloziert wurde. Durch densitometrische Messungen konnte ein geringer Verlust genetischen Materials an der Bruchstelle des Translokationschromosoms nachgewiesen werden.
    Notes: Summary Chromosome analysis in a 56-year-old woman with chronic myelocytic leukaemia revealed in cells of the peripheral blood a unique karyotype with a Philadelphia chromosome, whose missing segment was transferred to the long arms of the second chromosome No. 22. A small loss of genetic material at the break of the translocation chromosome was proved by photometric measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620749
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  • 4
    Electronic Resource
    Electronic Resource
    Der cytochemisch ermittelte Leukosetyp als prognostischer Parameter bei unreifzelligen Leukosen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 134-137 
    Details
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; classification ; effect of therapy ; prognosis ; Unreifzellige Leukosen ; Klassifizierung ; Therapieeffekt ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Komplette Remissionen und Überlebenszeiten von 81 Patienten mit unreifzelligen (akuten) Leukosen wurden zwischen Gruppen, die nach cytochemischen Kriterien ermittelt worden waren, verglichen. Die Klassifizierung erfolgte nach den Ergebnissen von PAS-, Peroxydase-und Esterase-Reaktionen. Eine signifikant höhere Rate an kompletten Remissionen und längere Überlebenszeiten wurden bei den Leukosen vom PAS-Typ im Vergleich zu allen anderen Formen festgestellt. Bei Erwachsenen und Kindern unterschied sich dieser Leukosetyp in der Remissionsrate nicht. Hieraus wird die Forderung abgeleitet, daß Erwachsene mit Leukosen vom PAS-Typ dieselbe intensive Behandlung erfahren sollten wie Kinder.
    Notes: Summary 81 cases of acute leukaemia were classified according to cytochemical criteria. PAS, peroxidase and esterase reactions were used for classification. Rates of complete remissions and duration of survival after diagnosis in the different groups were compared. A significant higher rate of complete remissions and longer duration of survival was detected in PAS type leukaemias compared to all the other types in adults. There was no significant difference in the remission rates between PAS type leukaemias in children and adults treated for at least 7 days. These results lead to the conclusion that adults with this type of acute leukaemia should receive the same treatment as children do.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620751
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  • 5
    Electronic Resource
    Electronic Resource
    Plasmazelleinschlüsse bei Mangel an saurer Maltase (Glycogenose Typ II) (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 653-654 
    Details
    ISSN: 1432-1440
    Keywords: Glycogenosis type II-acid maltase deficiency ; plasma cells ; lymphocytes ; inclusion bodies ; electron microscopy ; microspectrophotometry ; cytochemistry ; Glykogenose II — (Saurer Maltasemangel) ; Plasmazellen ; Lymphocyten ; Einschlüsse ; Elektronenmikroskopie ; Mikrospektrophotometrie ; Cytochemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Glykogenose II — Sauerer Maltasemangel — wurden bei einem erwachsenen Patienten regelmäßig Vacuolen in Plasmazellen und vereinzelt in Lymphocyten gefunden, die nach elektronenmikroskopischen, mikrospektrophotometrischen und cytochemischen Untersuchungen Glykoproteideinschlüssen entsprechen.
    Notes: Summary Vacuoles could be demonstrated in nearly all plasma cells and in some lymphocytes of an adult with glycogenosis type II-acid maltase deficiency. Electronmicroscopical, microspektrophotometrical, and cytochemical investigations revealed glycoproteid inclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468804
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  • 6
    Electronic Resource
    Electronic Resource
    Coxsackievirus infection in skeletal muscles of mice an electron microscopic study II. Appearance and fate of virus progeny (1970)
    Springer
    Archives of virology 31 (1970), S. 257-265 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different arrangements of coxsackievirus A1 in striated muscle of new born mice display different fates of the virus progeny: 1. Two-dimensional crystals and rows of virus particles between membranes represent the mechanism, by which virus is continuously released from the cell. Such formations are always found at the periphery of the cell, virions being thereby transported more or less directly from a nuclear pore to the sarcolemm. By this way, infection is spread from one cell to another. 2. Larger or smaller virus crystals in vacuoles are non-released virions, which have been accidentally trapped by autophagic vacuoles. Later on they are converted into phosphatase positive autolysosomes. The possible sites of virus synthesis as well as some aspects of cellular defense are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253760
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  • 7
    Electronic Resource
    Electronic Resource
    Coxsackievirus infection in skeletal muscles of mice An electron microscopic study I. Cell- and nucleus alterations (1970)
    Springer
    Archives of virology 31 (1970), S. 247-256 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cell- and nucleus alterations of coxsackievirus A1 infected striated muscles of newborn mice are described: The first signs of an infection are always found in the nucleus, where the chromatin becomes condensed at the periphery. Swelling of the perinuclear space is followed by the development of vacuoles and channels formed by the nuclear membrane. This membrane coates also deep invaginations into the lobed nucleus. Electron-light areas of the nucleus contain granular and fibrillar inclusions. Only after the beginning of nuclear alteration, cytoplasmic degeneration is noted, starting with vacuolisation of the ER and going on with the disintegration of the contractile material followed by the formation of islets of organelles (vacuoles, mitochondria etc.) in large areas of completely disorganized filaments. The last stages are characterized by complete nuclear breakdown, loss of sarcolemm and immigration of phagocytes. These observations are compared with those made by other authors in genetic muscle dystrophies. The mechanisms of the cellular damage are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253759
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  • 8
    Electronic Resource
    Electronic Resource
    Extrakorporale Asparaginasetherapie bei Allergie und toxischen Nebenwirkungen (1977)
    Springer
    Annals of hematology 35 (1977), S. 179-186 
    Details
    ISSN: 1432-0584
    Keywords: L-Asparaginase ; extrakorporale Therapie ; ALL ; Nebenwirkungen ; L-asparaginase ; Extracorporeal therapy ; ALL ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary L-asparaginase therapy is often limited by allergy or toxicity and probably in some cases by antibody mediated inactivation of the enzyme. These problems can be avoided by extracorporeal application of l-asparaginase. As the enzyme is a stable tetramer with high molecular weight it cannot pass through the dialysis membrane in contrast to the amino acid l-asparagin which is destroyed. The resulting l-asparagin depletion of the plasma is sufficient for therapeutic success. Effective extracorporeal l-asparaginase therapy is demonstrated in two patients with ALL who were resistant to other chemotherapy and could not be treated intravenously because of allergy and toxicity.
    Notes: Zusammenfassung Allergie mit der Gefahr der Anaphylaxie, Toxizität und möglicherweise Inaktivierung durch Antikörper begrenzen den Einsatz von L-Asparaginase in der Leukämiebehandlung. Diese Probleme können durch die extrakorporale Anwendung umgangen werden. Sie ist möglich, weil das Enzym als stabiles Tetramer mit höherem Molekulargewicht Dialysemembranen nicht passiert, während die Aminosäure L-Asparagin aus dem Körper entfernt werden kann und dann abgebaut wird. Für den Therapieeffekt ist allein die L-Asparagindepletion notwendig. Am Besipiel von zwei Patienten mit ALL, die gegenüber anderer Chemotherapie résistent und wegen Allergie bzw. Toxizität parenteral nicht mit L-Asparaginase behandelt werden konnten, wird das Verfahren beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999458
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  • 9
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1975)
    Springer
    Annals of hematology 30 (1975), S. 287-289 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01635361
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  • 10
    Electronic Resource
    Electronic Resource
    HÄmatologen-Kongre\ Bad Nauheim 1975 (1976)
    Springer
    Annals of hematology 32 (1976), S. 269-269 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01005307
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