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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 46 (1968), S. 305-311 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An autopsy was performed in a 60 year-old man, who had shown during his life all the typical symptoms of Fabry's disease. The histological examination, especially that with polarized light showed apart from the well-known pathological changes several new findings: a storage of lipid could be found mainly in the whole smooth musculature, in the heart muscle and in autonomic nerve cells. The systematic involvement of these cell-groups seems to be typical for Fabry's disease, whereas the lipid storage in other organs, e.g. in the kidneys and in the reticulo-endothelial system must be regarded as secondary and therefore not specific. The pathological changes found in the postmortem examination allow a satisfactory explanation of the clinical symptoms.
    Notes: Zusammenfassung Bei einem mit 60 Jahren verstorbenen Manne, der zu Lebzeiten das Vollbild eines Morbus Fabry geboten hatte, wurde eine Obduktion durchgeführt. Die histologischen, insbesondere die polarisationsoptischen Untersuchungen ergaben neben einer Bestätigung bereits bekannter und gesicherter krankhafter Veränderungen eine Reihe neuer Befunde. So konnte eine Lipoidablagerung unter anderem in der gesamten glatten Muskulatur, im Herzmuskel und in vegetativen Ganglienzellen nachgewiesen werden. Gegenüber diesem systematischen und für den Morbus Fabry offenbar typischen Befall bestimmter Zellgruppen scheint die Speicherung in anderen Organen, so in der Niere und in den Zellen des RES sekundär und damit unspezifisch zu sein. — Die gefundenen morphologischen Veränderungen gestatten in ihrer Gesamtheit eine befriedigende Erklärung der vielfältigen klinischen Symptome.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 43 (1965), S. 49-51 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This report deals with enzyme studies in posttraumatic spleenectomized patients. A significant rise in ALD-, MDH-, GOT- and GPT-activity, a significant lowering in G-6-PDH activity and no significant increase in LDH- and SDH-activity was noted following spleenectomy. The possibility that a cell system of the spleen was involved in the breakdown of the enzymes is discussed.
    Notes: Zusammenfassung Es wird über Enzymstudien an Patienten berichtet, bei denen als Folge eines Unfalls die Milz entfernt wurde. Nach Verlust dieses Organs wurde eine signifikante Erhöhung der Aktivität der ALD, MDH, GOT und GPT festgestellt. Nicht signifikant erhöht waren LDH- und SDH-Aktivität, während die G-6-PDH-Aktivität signifikant erniedrigt gefunden wurde. Die Möglichkeit, daß ein in der Milz enthaltenes Zellsystem am Enzymabbau beteiligt ist, wird diskutiert.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 46 (1968), S. 72-76 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary New biochemical and pathological findings lead to the conclusion that Fabry's disease is a primary systematic disorder of the whole smooth musculature, of the heart-muscle and of the autonomic nervecells. The sometimes most striking storage of lipid in other cellgroups, e.g. in the kidney and the reticuloendothelial system must be regarded as secondary, the ceramide there being taken out of the urine or out of the blood. The primary involvement of certain cells can be explained by the supposition that trihexoseceramide, the substratum of the defect enzyme plays an important part in the metabolism of these cells. It seems to be possible to explain the other lipidoses in a similar way. — The systematic affection of the smooth musculature, the heart-muscle and the autonomic nervesystem as well as the secondary storage, especially in the lower nephrons of the kidneys are responsible for the multiple symptoms of Fabry's disease, which can thus be considered as the result of a single basic disorder.
    Notes: Zusammenfassung Neuere biochemische und pathologischanatomische Befunde sprechen dafür, daß es sich beim Morbus Fabry um eine primäre systematische Erkrankung der gesamten glatten Muskulatur, des Herzmuskels und der vegetativen Ganglienzellen handelt. Demgegenüber sind andere, unter Umständen sehr auffallende Lipoidablagerungen, z. B. in Niere und RES als sekundär aufzufassen und durch Aufnahme des Ceramids aus dem Harn bzw. dem Blut zu erklären. Der primäre Befall bestimmter Zellsysteme wird darauf zurückgeführt, daß in ihnen das Substrat des defekten Enzyms, das Trihexose-Ceramid als Metabolit eine besondere Rolle spielt. Derartige Überlegungen können mutatis mutandis auch für die übrigen Lipidosen angewandt werden. — Der regelhafte Befall von glatter Muskulatur, Herzmuskel und vegetativem Nervensystem, sowie von den sekundären Lipoidablagerungen vor allem die Speicherung in den Nierentubuli sind verantwortlich für das klinische Bild des M. Fabry und gestatten eine einheitliche Erklärung der so vielfältigen Symptomatologie.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 152 (1966), S. 332-341 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Da offensichtlich nur ein kleiner Teil aller Koagulase-positiven und damit als pathogen klassifizierten Staphylokokken die aktuelle Fähigkeit besitzt, pyogene Prozesse hervorzurufen, benötigt man für die epidemiologische Praxis eine Methode, mit deren Hilfe sich die pyogene Potenz von Staphylococcus aureus mit einiger Sicherheit abschätzen läßt. Da nach unseren Beobachtungen ein hoher Prozentsatz der aus menschlichem Eiter isolierten St. a.-Stämme gegen bestimmte Testphagen empfindlich ist, wird von uns ein Phagengemisch aus den Phagen 80, 81, 812, 825, 77, 3C und 71 zur gezielten Auslese von potentiell pyogenen St. a.-Stämmen verwendet. Zur Beurteilung ziehen wir außerdem den Kristallviolett-Test, den Sublimat-Test und das Antibiogramm heran. Selbstverständlich berücksichtigen wir bei der Auswertung die jeweiligen epidemiologischen Erfahrungen.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 2590-2602 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Sub-Doppler laser spectroscopy of the A 2E″←X 2E′ band of Li3 shows well-resolved and characteristic hyperfine structures of rovibronic transitions which can be explained in all detail by the interplay between the underlying Fermi-contact interaction, the symmetry species of the rovibronic states and the Coriolis coupling of rotational and pseudorotational motions. Ab initio calculated electron spin densities reproduce the observed line splittings to within 3%. In this Jahn–Teller distorted molecule magnetic equivalence of identical nuclei is strictly valid only for rovibronic states of A symmetry. However, it also holds for rovibronic states of E symmetry if they are of pure A vibronic origin, and it is enforced for many E states of pure E vibronic origin by Coriolis coupling. In contrast, those transitions which involve states with dominant Kc=0 rotation functions and/or with strong vibronic E/A mixing show significant changes in the hyperfine patterns due to magnetic inequivalence, sometimes called "hyperfine doubling." © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 1484-1491 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A complete ab initio treatment is applied to the autoionization process in the He*(2s 3S)+Li(2s 2S) collisional complex. Feshbach projection based on orbital occupancy, implemented in a multireference configuration interaction (MRCI) code, defines the resonance state and provides the entrance channel potential curve as well as all pertinent information on the resonance–continuum coupling. The l-dependent coupling elements in local approximation are obtained by projecting a compact one-electron function, named Penning molecular orbital (PMO), onto the wave function of the ejected electron with proper energy. The continuum wave function is obtained by coupled channel calculations in the static-exchange approximation. A converged set of seven complex coupling matrix elements, used in the nuclear dynamics calculation based on a complex Numerov algorithm, fully describes the electron angular momentum transfer. The calculated angle-dependent spectra, as well as the total, angle-, and energy-integrated ionization cross sections agree well with available experimental data. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 1340-1342 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Gold Schottky-barrier diodes (SBDs) were fabricated on vapor-phase-grown single-crystal ZnO. Deep-level transient spectroscopy, using these SBDs, revealed the presence of four electron traps, the major two having levels at 0.12 eV and 0.57 below the conduction band. Comparison with temperature-dependent Hall measurements suggests that the 0.12 eV level has a temperature activated capture cross section with a capture barrier of about 0.06 eV and that it may significantly contribute to the free-carrier density. Based on the concentrations of defects other than this shallow donor, we conclude that the quality of the vapor-phase-grown ZnO studied here supercedes that of other single-crystal ZnO reported up to now. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 32 (2003), S. 0 
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During the critical early postnatal period, the development of lymphatic organs, being the major structural components of the immune system, progresses rapidly. In this context, the growth kinetics and growth rates of Peyer's patches, tonsilla veli palatini, lymphnodes (lc. mesentericum craniale and lc. bronchale), spleen and thymus were investigated in German landrace piglets from birth until 2 weeks of age. The weight of all these organs increased faster than body weight but regression analysis revealed remarkable differences in growth kinetics and growth rates. The lymphoepithelial organs (Peyer's patches, tonsilla veli palatini) had low growth rates at birth (∼10%/day) that increased continuously until 2 weeks, while lymphnodes and spleen exhibited constant high growth rates (∼40%/day). Small intestinal lymphnodes alone showed biphasic growth kinetics which could be attributed to colostrum absorption. The growth kinetics of the thymus included a point of inflexion at the end of the first week. The differences in growth kinetics and growth rates are discussed with regard to their immunobiological relevance.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Notfall + Rettungsmedizin 3 (2000), S. 13-21 
    ISSN: 1436-0578
    Keywords: Schlüsselwörter Psychologie ; Notfallmedizin ; Reanimation ; Notärzte ; Entscheidungskonflikte ; Posttraumatische Belastungsstörungen ; Debriefing ; Key words Emergency medicine psychology ; Resuscitation psychology ; Physicians' psychology ; Decision making ; Attitude of health personnel ; Posttraumatic stress disorders ; Debriefing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Seventy-six physicians, working on a German Mobil Resuscitation Unit, were examined by use of a modified Gottschalk-Gleser technique. The aim was to describe scores for anxiety, hostility and hope and to compare those to the values of a normal population. Physicians' sumscores differed from those of a normal population: Anxiety and hostility were significantly higher. Singlescores for death-, separation- and shame-anxiety were higher, those for injury-anxiety and diffuse anxiety were lower. Guilt anxiety did not differ. Scores for hostility outward open were the same, whereas hostility outward covered and inward were higher than in the normal population. Ambivalent hostility was the same. Scores for positive hope were significantly lower, those for negative hope the same than in the normal population. In conclusion we found three possible obstacles for resuscitating physicians in dealing with anxiety, hostility and hope: Compared to the normal population physicians seem to deal less with injury-, guilt- and diffuse anxiety. Dealing with hostility reveals mechanisms of repression, projection and turning hostility towards the own person. Compared to the normal population resuscitating physicians tend not to talk more about the hopelessness related to their work.
    Notes: Zusammenfassung 76 Ärzte eines Notarztwagensystems wurden mittels eines modifizierten Gottschalk-Gleser-Interviews untersucht. Dabei wurden Scores für Angst, Hoffnung und Aggression von Ärzten in ihrem Bericht über die Durchführung präklinischer Wiederbelebungen erfaßt und mit den Werten einer Normalbevölkerungsstichprobe verglichen. Ärzte wiesen signifikant höhere Werte für Angst- und Aggressionssummenscores auf als die Vergleichsstichprobe. Einzelscores für Todes-, Trennungs- und Schamangst waren signifikant höher, für Verletzungsangst und diffuse Angst niedriger als in der Normalbevölkerung. Die Schuldangst unterschied sich nicht. Die Ergebnisse für offen nach außen gerichtete Aggressivität waren gleich, die für nach außen verdeckte und nach innen gerichtete Aggressivität waren signifikant höher als in der Normalbevölkerung. Bei der ambivalenten Aggressivität zeigte sich kein Unterschied. Scores der Ärzte für positive Hoffnung waren signifikant niedriger, diejenigen für negative Hoffnung unterschieden sich nicht von der Normalbevölkerung. Im Vergleich zur Normalbevölkerung ergaben sich insgesamt drei Hinweise auf Hindernisse für Ärzte, mit Angst, Hoffnung und Aggressivität in Reanimationssituationen angemessen umzugehen: Ärzte scheinen sich weniger mit Verletzungs-, diffuser- sowie Schuldangst auseinanderzusetzen. Der Umgang mit Aggressionen offenbart Mechanismen der Verdrängung, Projektion und Wendung gegen das Selbst. Gegenüber der Normalbevölkerung scheinen Ärzte nicht intensiver über die mit ihrer Tätigkeit verbundene Hoffnungslosigkeit zu sprechen.
    Type of Medium: Electronic Resource
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  • 10
    facet.materialart.
    Unknown
    Wien : Periodicals Archive Online (PAO)
    Journal of economics/Zeitschrift für Nazionalökonomie. 29 (1969) 194 
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