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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 11 (1985), S. 62-64 
    ISSN: 1619-7089
    Keywords: Ammonia ; Diagnosis ; Emission spectroscopy ; Isotope application ; Liver ; Nitrogen-15 ; Tracer technique ; Urea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Malfunction of the liver involves disturbances of urea synthesis and ammonia detoxification. These phenomena became apparent, especially during ammonia loading of patients. The functional state of the liver can be assessed by oral administration of 15NH4Cl and subsequent analysis of 15N-urea and 15N-ammonia in urine by emission spectrometry. Clinical tests based on the ratio of the excess abundances (see Appendix) of 15N-ammonia to 15N-urea excreted in urine 3 h after oral administration gave values for patients with liver disease which differed significantly from those for healthy subjects. Absorption disturbances, which often accompany liver diseases, do not influence the effectiveness of the method.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 11 (1985), S. 58-61 
    ISSN: 1619-7089
    Keywords: Children ; Diagnostic techniques ; Diseases ; Drugs ; Function tests ; Isotope applications ; Liver ; Metabolism ; Nitrogen-15 ; Pregnant women ; Stable isotopes ; Urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A simple, non-invasive, non-radioactive liverfunction test is proposed. After an oral dose of 3 mg 15N-methacetin per kilogram body mass, the kinetics of 15N excretion via urine were characterized by the quotient of the amounts of 15N excreted in two successive urine samples (Q value). The stable nitrogen isotope 15N was found to be an excellent and easily detectable indicator of the sum of all methacetin metabolites present in urine. Alterations in the nature or ratio of methacetin metabolites due to liver diseases could not be found. From the investigation of 11 men, 3 pregnant women and 15 children, a clear difference was observed in Q values of healthy persons and patients suffering from liver-cell-activity diseases. The discriminating power of our new liver-function test is shown to be equivalent to that of the 14CO2 breath test.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-601X
    Keywords: 21.10.Dr ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Theβ-decay of neutron-rich fission products with mass numbersA=107, 108 and 109 has been investigated at the mass separator LOHENGRIN of the Institute Laue-Lange-vin (ILL) in Grenoble by measuringβγ-coincidences with a large plastic scintillator telescope and a Ge(I)-detector. Theβ-decay energies of 8 nuclei were obtained from the evaluation of more than 40β-endpoint energies. For the nuclei107 Mo,107Tc,108Tc,109Tc and109Ru, theβ-decay energies were determined for the first time; the experimental error in the decay energy of three daughter nuclei was considerably reduced. In addition, the two-neutron separation energies and the nuclear mass excesses were calculated from these experimentalQ β-values and compared with different mass predictions.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-601X
    Keywords: 21.10.Dr ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Theβ-decay energy of the neutron-rich isotopes148Ba,148La and151Pr has been measured at the Institute Laue-Langevin (ILL). The148Ba- and148La-nuclei were produced using a high-temperature ion source at the OSTIS separator of this institute, whereas samples of151Pr were obtained from the thermal fission of239Pu, used as a target in the mass separator LOHENGRIN. At both instruments,βγ-coincidences were measured with a plastic scintillator telescope and a Ge(I)-detector, together withβ-singles andγ-singles spectra. Theβ-spectra emitted in coincidence with 44γ-lines in the decay of these nuclei have been evaluated. From their endpoint energies, the followingQ β -values have been obtained:Q β (148Ba)=5115±60keV;Q β (148La)=7255±55 keV;Q β (151Pr)=4170±75 keV. Using these results, the nuclear massesA of these nuclei can be calculated with a relative error ΔA/A≃5·10−7. In addition, the two-neutron separation energies and the mass excesses have been derived; the results are compared with recent predictions of theoretical mass calculations.
    Type of Medium: Electronic Resource
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